X0508 4 2024-02-21 0 0001124140 EXACT SCIENCES CORP EXAS 0001306119 Conroy Kevin T C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 1 1 0 0 President and CEO 1 Common Stock 2024-02-21 4 A 0 23238 0.00 A 1252994 D Common Stock 2024-02-22 4 S 0 11565 59.78 D 1241429 D Common Stock 27924 I Held in 401(k) Plan Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21729 I Held in Grantor Retained Annuity Trust Represents shares of common stock received upon settlement of a performance share unit award on February 21, 2024. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain performance stock units. In addition to the shares of Common Stock reported on this Form 4, which total 1,334,542 shares, Mr. Conroy also holds, in the aggregate, an additional 728,507 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Kevin T. Conroy by Mark R. Busch, attorney-in-fact 2024-02-23