X0508 4 2024-02-14 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Financial Officer 1 Common Stock 2024-02-14 4 M 0 3972 0.00 A 3972 D Common Stock 2024-02-15 4 S 0 1888 61.43 D 2084 D Common Stock 1313 I Held in 401(k) Plan Restricted Stock Units 2024-02-14 4 M 0 3972 0.00 D Common Stock 3972 0 D Represents shares of common stock received upon vesting of a restricted stock unit award. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on February 14, 2024. In addition to the shares of Common Stock reported on this Form 4, which total 3,397 shares, Mr. Elliott also holds, in the aggregate, an additional 143,791 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award that fully vested on February 14, 2024. /s/ Jeffrey T. Elliott by Mark R. Busch, attorney-in-fact 2024-02-16