X0407 4 2023-05-10 0 0001124140 EXACT SCIENCES CORP EXAS 0001839989 Condella Sarah C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 EVP, Human Resources 1 Common Stock 2023-05-10 4 S 0 6087 80.00 D 80314 D Common Stock 5425 I Held in 401(k) Plan The sale reported in this field was effected pursuant to a Rule 10b5-1 trading plan entered into on February 28, 2022. In addition to the shares of Common Stock reported on this Form 4, which total 85,739 shares, Ms. Condella also holds, in the aggregate, an additional 85,425 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Sarah Condella by Mark R. Busch, attorney-in-fact 2023-05-12