X0306 4 2023-02-24 0 0001124140 EXACT SCIENCES CORP EXAS 0001306119 Conroy Kevin T C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 1 1 0 0 President and CEO Common Stock 1195230 D Common Stock 27125 I Held in 401(k) Plan Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21729 I Held in Grantor Retained Annuity Trust Restricted Stock Units 2023-02-24 4 A 0 72572 0.00 A Common Stock 72572 72572 D In addition to the shares of Common Stock reported on this Form 4, which total 1,287,544 shares, Mr. Conroy also holds, in the aggregate, an additional 792,505 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on February 29, 2024. /s/ Kevin T. Conroy by Mark R. Busch, attorney-in-fact 2023-02-28