X0306 4 2023-02-24 0 0001124140 EXACT SCIENCES CORP EXAS 0001564777 Cunningham Everett C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Commercial Officer Common Stock 18654 D Restricted Stock Units 2023-02-24 4 A 0 21167 0.00 A Common Stock 21167 21167 D In addition to the shares of Common Stock reported on this Form 4, which total 18,654 shares, Mr. Cunningham also holds, in the aggregate, an additional 106,888 restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on February 29, 2024. /s/ Everett Cunningham by Mark R. Busch, attorney-in-fact 2023-02-28