X0306 4 2022-02-25 0 0001124140 EXACT SCIENCES CORP EXAS 0001564777 Cunningham Everett C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Commercial Officer Restricted Stock Units 2022-02-25 4 A 0 30711 0.00 A Common Stock 30711 30711 D Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on the first anniversary of the grant date. In addition to the shares of Restricted Stock Units reported on this Form 4, Mr. Cunningham holds, in the aggregate, 120,726 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Everett Cunningham by Mark R. Busch, attorney-in-fact 2022-03-01