X0306 4 2022-02-22 0 0001124140 EXACT SCIENCES CORP EXAS 0001839989 Condella Sarah C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 SVP, Human Resources Common Stock 2022-02-22 4 M 0 2247 0.00 A 83821 D Common Stock 2022-02-23 4 S 0 1124 69.05 D 82697 D Common Stock 4922 I Held in 401(k) Plan Restricted Stock Units 2022-02-22 4 M 0 2247 0.00 D Common Stock 2247 6744 D Represents shares of common stock received upon vesting of a restricted stock unit award. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on February 22, 2022. In addition to the shares of Common Stock reported on this Form 4, which total 87,619 shares, Ms. Condella also holds, in the aggregate, an additional 70,961 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award that partially vested on February 22, 2022. The restricted stock units vest in four equal annual installments beginning on February 19, 2022. /s/ Sarah Condella by Mark R. Busch, attorney-in-fact 2022-02-24