X0306 4 2022-01-14 0 0001124140 EXACT SCIENCES CORP EXAS 0001306119 Conroy Kevin T C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 1 1 0 0 President and CEO Common Stock 2022-01-14 4 A 0 6407 0.00 A 670787 D Common Stock 26553 I Held in 401(k) Plan Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21729 I Held in Grantor Retained Annuity Trust Represents restricted stock units issued to Mr. Conroy in lieu of one-half of his base salary for 2022. The restricted stock units vest in eleven equal monthly installments beginning on February 15, 2022. Each restricted stock unit represents a right to receive one share of Common Stock. As these restricted stock units vest, Mr. Conroy expects to pay the relevant income taxes out of his base salary or cash on hand, rather than selling shares to cover them. In addition to the shares of Common Stock reported on this Form 4, which total 762,529 shares, Mr. Conroy also holds, in the aggregate, an additional 1,207,918 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Kevin T. Conroy by Mark R. Busch, attorney-in-fact 2022-01-19