X0306 4 2021-09-01 0 0001124140 EXACT SCIENCES CORP EXAS 0001306119 Conroy Kevin T C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 1 1 0 0 President and CEO Common Stock 2021-09-01 4 S 0 18978 104.42 D 698380 D Common Stock 26499 I Held in 401(k) Plan Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21729 I Held in Grantor Retained Annuity Trust The sale reported in this field was effected pursuant to a Rule 10b5-1 trading plan, which trading plan was disclosed via Form 8-K filed by Exact Sciences Corporation with the U.S. Securities and Exchange Commission on November 27, 2020. In addition to the shares of Common Stock reported on this Form 4, which total 790,068 shares, Mr. Conroy also holds, in the aggregate, an additional 1,207,918 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Kevin T. Conroy by Mark R. Busch, attorney-in-fact 2021-09-03