X0306 4/A 2021-07-30 2021-08-02 0 0001124140 EXACT SCIENCES CORP EXAS 0001367313 Zanotti Katherine S C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 1 0 0 0 Common Stock 2021-07-30 4 S 0 1381 111.107 D 34741 D Common Stock 24796 I By grantor retained annuity trust The sale reported in this field was effected pursuant to a Rule 10b5-1 trading plan entered into in November 2020. On August 2, 2021 the reporting person filed a Form 4 to report certain sales made pursuant to a Rule 10bb5-1 trading plan entered into in November 2020 (the "Trading Plan"). This Form 4/A is being filed solely to denote that the reported sales were made pursuant to the Trading Plan. /s/ Katherine S. Zanotti by Mark R. Busch, attorney-in-fact 2021-08-03