X0306 4 2021-03-03 0 0001124140 EXACT SCIENCES CORP EXAS 0001247296 COWARD D SCOTT C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Administrative Officer Common Stock 2021-03-03 4 S 0 2664 135.02 D 1301 D Common Stock 4194 I Held in 401(k) Plan The sale reported in this field was effected pursuant to a Rule 10b5-1 trading plan. In addition to the shares of Common Stock reported on this Form 4, which total 5,495 shares, Mr. Coward also holds, in the aggregate, an additional 60,294 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ D. Scott Coward by Mark R. Busch, attorney-in-fact 2021-03-05