X0306 4 2021-02-19 0 0001124140 EXACT SCIENCES CORP EXAS 0001247296 COWARD D SCOTT C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Administrative Officer Common Stock 1301 D Common Stock 4073 I Held in 401(k) Plan Restricted Stock Units 2021-02-19 4 A 0 8991 0.00 A Common Stock 8991 8991 D In addition to the shares of Common Stock reported on this Form 4, which total 5,374 shares, Mr. Coward also holds, in the aggregate, an additional 104,357 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on the first anniversary of the grant date. /s/ D. Scott Coward by Mark R. Busch, attorney-in-fact 2021-02-23