X0306 4 2020-12-01 0 0001124140 EXACT SCIENCES CORP EXAS 0001306119 Conroy Kevin T C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 1 1 0 0 President and CEO Common Stock 2020-12-01 4 S 0 1800 122.05 D 886295 D Common Stock 2020-12-01 4 S 0 2918 122.91 D 883377 D Common Stock 2020-12-01 4 S 0 7776 124.03 D 875601 D Common Stock 2020-12-01 4 S 0 10840 124.88 D 864761 D Common Stock 2020-12-01 4 S 0 7043 125.92 D 857718 D Common Stock 2020-12-01 4 S 0 100 126.49 D 857618 D Common Stock 2020-12-01 4 S 0 100 126.59 D 857518 D Common Stock 26305 I Held in 401(k) Plan Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21730 I Held in Grantor Retained Annuity Trust Common Stock 21729 I Held in Grantor Retained Annuity Trust The sale reported in this field was effected pursuant to a Rule 10b5-1 trading plan, which trading plan was disclosed via Form 8-K filed by Exact Sciences Corporation with the U.S. Securities and Exchange Commission on November 27, 2019. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $121.42 to $122.38, inclusive. The reporting person undertakes to provide to Exact Sciences Corporation, any security holder of Exact Sciences Corporation, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this Footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $122.43 to $123.40, inclusive. The reporting person undertakes to provide to Exact Sciences Corporation, any security holder of Exact Sciences Corporation, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this Footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $123.43 to $124.42, inclusive. The reporting person undertakes to provide to Exact Sciences Corporation, any security holder of Exact Sciences Corporation, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this Footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $124.44 to $125.43, inclusive. The reporting person undertakes to provide to Exact Sciences Corporation, any security holder of Exact Sciences Corporation, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this Footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $125.47 to $126.31, inclusive. The reporting person undertakes to provide to Exact Sciences Corporation, any security holder of Exact Sciences Corporation, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this Footnote. In addition to the shares of Common Stock reported on this Form 4, which total 949,012 shares, Mr. Conroy also holds, in the aggregate, an additional 1,279,310 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Kevin T. Conroy by Mark R. Busch, attorney-in-fact 2020-12-02