X0306 4 2019-12-18 0 0001124140 EXACT SCIENCES CORP EXAS 0001337798 Cole G Bradley C/O EXACT SCIENCES CORP. 441 CHARMANY DRIVE MADISON WI 53719 0 1 0 0 General Manager - Diagnostics Common Stock 2019-12-04 5 G 0 E 12334 0.00 D 18653 D Common Stock 12334 I Held by Cole Family Trust Restricted Stock Units 2019-12-18 4 A 0 9620 0.00 A Common Stock 9620 9620 D In addition to the shares of Common Stock reported on this Form 4, which total 30,987 shares, Mr. Cole also holds, in the aggregate, an additional 70,733 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in full on December 31, 2020. /s/ G. Bradley Cole by Mark R. Busch, attorney-in-fact 2019-12-20