X0306 4 2019-02-26 0 0001124140 EXACT SCIENCES CORP EXAS 0001734751 Stenhouse Mark 441 CHARMANY DRIVE MADISON WI 53719 0 1 0 0 President, Cologuard Common Stock 500 D Common Stock 163 I Held in 401(K) Plan Stock Option (right to buy) 92.62 2019-02-26 4 A 0 10786 0.00 A 2020-02-26 2029-02-26 Common Stock 10786 10786 D Restricted Stock Units 2019-02-26 4 A 0 13051 0.00 A Common Stock 13051 13051 D In addition to the shares of Common Stock reported on this Form 4, which total 663 shares, Mr. Stenhouse also holds, in the aggregate, an additional 98,837 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. These options vest and become exercisable in four equal annual installments beginning on the first anniversary of the grant date. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on the first anniversary of the grant date. /s/ Mark Stenhouse by Mark R. Busch, attorney-in-fact 2019-02-28