X0306 4 2019-02-26 0 0001124140 EXACT SCIENCES CORP EXAS 0001306119 Conroy Kevin T C/O EXACT SCIENCES CORP. 441 CHARMANY DRIVE MADISON WI 53719 1 1 0 0 President and CEO Common Stock 2019-02-26 4 M 0 20025 0.00 A 923961 D Common Stock 2019-02-27 4 S 0 9169 95.074 D 914792 D Common Stock 2019-02-27 4 M 0 20575 0.00 A 935367 D Common Stock 25913 I Held in 401(K) Plan Common Stock 65189 I Held in Grantor Retained Annuity Trust Restricted Stock Units 2019-02-26 4 M 0 20025 0.00 D Common Stock 20025 20025 D Stock Option (right to buy) 92.62 2019-02-26 4 A 0 34110 0.00 A 2020-02-26 2029-02-26 Common Stock 34110 34110 D Restricted Stock Units 2019-02-26 4 A 0 37248 0.00 A Common Stock 37248 37248 D Restricted Stock Units 2019-02-27 4 M 0 20575 0.00 D Common Stock 20575 61725 D Represents shares of common stock received upon vesting of a restricted stock unit award on February 26, 2019. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on February 26, 2019. Represents shares of common stock received upon vesting of a restricted stock unit award on February 27, 2019. In addition to the shares of Common Stock reported on this Form 4, which total 1,026,469 shares, Mr. Conroy also holds, in the aggregate, an additional 1,173,941 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award granted on February 26, 2016 that partially vested on February 26, 2019. The restricted stock units vest in four equal annual installments beginning on February 26, 2017. These options vest and become exercisable in four equal annual installments beginning on the first anniversary of the grant date. These restricted stock units vest in four equal annual installments beginning on the first anniversary of the grant date. Represents a restricted stock unit award granted on February 27, 2018 that partially vested on February 27, 2019. The restricted stock units vest in four equal annual installments beginning on February 27, 2019. /s/ Kevin T. Conroy by Mark R. Busch, attorney-in-fact 2019-02-28