X0306 4 2018-04-10 0 0001124140 EXACT SCIENCES CORP EXAS 0001574633 Carey Thomas D. C/O EXACT SCIENCES CORP. 441 CHARMANY DRIVE MADISON WI 53719 1 0 0 0 Common Stock 2018-04-10 4 S 0 8248 39.702 D 52610 D Common Stock 2018-04-10 4 S 0 200 40.838 D 52410 D The sales reported in this Column 4 were effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person to cover tax liabilities arising out of the vesting of shares of restricted stock. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.34 to $40.23, inclusive. The reporting person undertakes to provide to Exact Sciences Corporation, any security holder of Exact Sciences Corporation, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.69 to $40.985, inclusive. The reporting person undertakes to provide to Exact Sciences Corporation, any security holder of Exact Sciences Corporation, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4. /s/ Thomas D. Carey by Mark R. Busch, attorney-in-fact 2018-04-12