X0306 4 2018-01-02 0 0001124140 EXACT SCIENCES CORP EXAS 0001247296 COWARD D SCOTT C/O EXACT SCIENCES CORP. 441 CHARMANY DRIVE MADISON WI 53719 0 1 0 0 SVP and General Counsel Common Stock 2017-10-31 5 A 0 E 1682 5.95 A 37558 D Common Stock 2018-01-02 4 M 0 4687 0.00 A 42245 D Common Stock 2018-01-03 4 S 0 1665 52.537 D 40580 D Common Stock 3363 I Held in 401(K) Account Restricted Stock Units 2018-01-02 4 M 0 4687 0.00 D Common Stock 4687 18750 D Represents shares purchased through Employee Stock Purchase Plan. Represents shares of common stock received upon vesting of a restricted stock unit award on December 31, 2017 and delivered on January 2, 2018. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on December 31, 2017. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award granted on January 1, 2015 that partially vested on December 31, 2017 and which shares were delivered on January 2, 2018. The restricted stock units vest as follows: one-quarter on the first anniversary of the grant date and the balance in equal quarterly installments over the three year period beginning on the one-year anniversary of the grant date. /s/ D. Scott Coward by Mark R. Busch, attorney-in-fact 2018-01-04