Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Cash flows from operating activities:
Net loss	$ (154,383)	$ (495,761)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation	83,587	73,541
Unrealized loss on equity investments	15,622	3,497
Deferred tax benefit	(279)	(9,346)
Stock-based compensation	172,735	160,906
Realized (gain) loss on non-marketable investment	(5,358)	10,000
Gain on settlements of convertible notes, net	(10,324)	0
Amortization of acquired intangible assets	68,849	74,536
Impairment of long-lived assets	621	12,537
Loss on sale of asset	0	13,244
Gain on contingent consideration from sale of asset	(68,900)	0
Remeasurement of contingent consideration liabilities	(13,051)	(57,619)
Non-cash lease expense	20,918	24,452
Other	3,530	9,151
Changes in assets and liabilities:
Accounts receivable, net	(40,306)	27,968
Inventory, net	(13,074)	(9,705)
Operating lease liabilities	(19,741)	(16,242)
Accounts payable and accrued liabilities	51,084	(89,268)
Other assets	3,686	4,901
Other liabilities	(1,274)	(2,586)
Net cash provided by (used in) operating activities	86,570	(275,596)
Cash flows from investing activities:
Purchases of marketable securities	(75,096)	(102,438)
Maturities and sales of marketable securities	328,054	377,440
Purchases of property, plant and equipment	(89,268)	(141,586)
Proceeds from sale of asset	0	25,000
Business combination, net of cash acquired	(50,000)	685
Sales of investments in privately held companies	9,296	0
Investments in privately held companies	(6,290)	(26,827)
Other investing activities	(250)	(49)
Net cash provided by investing activities	116,446	132,225
Cash flows from financing activities:
Proceeds from exercise of common stock options	2,893	5,966
Proceeds in connection with the Company’s employee stock purchase plan	16,344	15,529
Proceeds from issuance of convertible notes	0	50,000
Proceeds from issuance of convertible notes	137,976	0
Other financing activities	(7,484)	(5,113)
Net cash provided by financing activities	149,729	66,382
Effects of exchange rate changes on cash and cash equivalents	(626)	(3,176)
Net increase (decrease) in cash, cash equivalents and restricted cash	352,119	(80,165)
Cash, cash equivalents and restricted cash, beginning of period	242,790	315,768
Cash, cash equivalents and restricted cash, end of period	594,909	235,603
Supplemental disclosure of non-cash investing and financing activities
Property, plant and equipment acquired but not paid	14,422	23,659
Supplemental disclosure of cash flow information:
Interest paid	18,176	10,754
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	594,612	235,306
Restricted cash — included in prepaid expenses and other current assets	297	297
Total cash, cash equivalents and restricted cash	$ 594,909	$ 235,603