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We hereby consent to the incorporation by reference in this Registration Statement on Form S-3 of Exact Sciences Corporation of our report dated February 21, 2023 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in Exact Sciences Corporation's Annual Report on Form 10-K for the year ended December 31, 2022. We also consent to the reference to us under the heading “Experts” in such Registration Statement.