Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Cash flows from operating activities:
Net loss	$ (623,506)	$ (595,625)	$ (823,605)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation	100,108	85,345	69,964
Loss on disposal of property, plant and equipment	1,863	1,055	2,470
Unrealized (gain) loss on equity investments	11,774	1,492	(1,179)
Deferred tax benefit	(11,901)	(253,169)	(6,748)
Stock-based compensation	206,823	253,063	152,906
Post-combination expense for acceleration of unvested equity	0	80,960	0
Realized (gain) loss on non-marketable investments	10,000	(30,500)	0
Loss on settlement of convertible notes	0	0	50,819
Amortization of deferred financing costs, convertible note debt discount and issuance costs, and other liabilities	7,127	6,683	1,546
Amortization of premium on short-term investments	1,845	4,618	1,549
Amortization of acquired intangible assets	97,450	95,001	93,398
Asset acquisition IPR&D expense	0	85,337	412,568
Loss on sale of asset	13,244	0	0
Impairment of long-lived assets	15,969	20,210	209,666
Remeasurement of contingent consideration	(56,617)	6,360	(323)
Non-cash lease expense	28,639	25,825	15,720
Changes in assets and liabilities, net of effects of acquisition:
Accounts receivable, net	61,088	25,150	(100,526)
Inventory, net	(13,231)	(9,221)	(30,310)
Operating lease liabilities	(20,646)	(16,685)	(8,784)
Accounts payable and accrued liabilities	(52,180)	169,800	55,165
Other assets and liabilities	(1,408)	(57,935)	42,186
Net cash provided by (used in) operating activities	(223,559)	(102,236)	136,482
Cash flows from investing activities:
Purchases of marketable securities	(131,486)	(1,164,050)	(1,089,953)
Maturities of marketable securities	453,072	794,322	886,675
Purchases of property, plant and equipment	(214,462)	(135,766)	(65,078)
Proceeds from Sale of Productive Assets	25,000	0	0
Investment in privately held companies	(42,823)	(18,044)	(15,947)
Business combination, net of cash acquired and issuance costs	(14,686)	(499,730)	(6,658)
Asset acquisitions, net of cash acquired	0	(58,073)	(411,421)
Other investing activities	(549)	(744)	345
Net cash provided by (used in) investing activities	74,066	(1,082,085)	(702,037)
Cash flows from financing activities:
Proceeds from issuance of convertible notes, net	0	0	1,125,547
Proceeds from exercise of common stock options	6,524	14,437	27,077
Proceeds from sale of common stock, net of issuance costs	0	0	861,701
Proceeds in connection with the Company's employee stock purchase plan	25,491	23,070	18,355
Payments on settlement of convertible notes	0	0	(150,054)
Payments on construction loan	0	(23,749)	(1,250)
Other financing activities	(5,530)	(5,286)	(1,755)
Net cash provided by financing activities	76,485	8,472	1,879,621
Effects of exchange rate changes on cash and cash equivalents	30	23	0
Net increase (decrease) in cash, cash equivalents and restricted cash	(72,978)	(1,175,826)	1,314,066
Cash, cash equivalents and restricted cash at the beginning of period	315,768	1,491,594	177,528
Cash, cash equivalents and restricted cash at the end of period	242,790	315,768	1,491,594
Supplemental disclosure of non-cash investing and financing activities:
Property, plant and equipment acquired but not paid	15,943	33,177	2,685
Business acquisition contingent consideration liability	4,600	350,348	0
Supplemental disclosure of cash flow information:
Interest paid	11,519	10,735	9,384
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	242,493	315,471	1,491,288
Restricted cash — included in prepaid expenses and other current assets as of December 31, 2022, and other long-term assets, net as of December 31, 2021 and 2020	297	297	306
Total cash, cash equivalents and restricted cash	242,790	315,768	1,491,594
Proceeds from Accounts Receivable Securitization	$ 50,000	$ 0	$ 0