Consolidated Statements of Stockholders’ Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid In Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2019		147,625,696
Beginning balance at Dec. 31, 2019	$ 1,957,639	$ 1,477	$ 3,178,552	$ (100)	$ (1,222,290)
Increase (Decrease) in Stockholders' Equity
Exercise of common stock options (in shares)		702,907
Exercise of common stock options	27,077	$ 7	27,070
Issuance of common stock to fund the Company's 401(k) match (in shares)		136,559
Issuance of common stock to fund the Company’s 2019 401(k) match	12,007	$ 1	12,006
Compensation expense related to issuance of stock options and restricted stock awards (in shares)		1,665,408
Compensation expense related to issuance of stock options and restricted stock awards	152,906	$ 17	152,889
Purchase of employee stock purchase plan shares (in shares)		301,064
Purchase of employee stock purchase plan shares	18,355	$ 3	18,352
Issuance of common stock to fund business combinations (in shares)		386,293
Issuance of common stock for business combinations and asset acquisitions	28,847	$ 4	28,843
Issuance of common stock for registered direct offering (in shares)		8,605,483
Issuance of common stock for registered direct offering	861,701	$ 86	861,615
Net loss	(823,605)				(823,605)
Other comprehensive income	626			626
Ending balance (in shares) at Dec. 31, 2020		159,423,410
Ending balance at Dec. 31, 2020	2,235,553	$ 1,595	4,279,327	526	(2,045,895)
Increase (Decrease) in Stockholders' Equity
Conversion of convertible notes, net of tax (in shares)		580
Conversion of convertible notes, net of tax	43		43
Exercise of common stock options (in shares)		1,295,104
Exercise of common stock options	14,437	$ 13	14,424
Issuance of common stock to fund the Company's 401(k) match (in shares)		162,606
Issuance of common stock to fund the Company’s 2019 401(k) match	22,934	$ 2	22,932
Compensation expense related to issuance of stock options and restricted stock awards (in shares)		1,879,169
Compensation expense related to issuance of stock options and restricted stock awards	334,023	$ 19	334,004
Purchase of employee stock purchase plan shares (in shares)		331,769
Purchase of employee stock purchase plan shares	23,070	$ 3	23,067
Issuance of common stock to fund business combinations (in shares)		10,581,429
Issuance of common stock for business combinations and asset acquisitions	1,355,170	$ 106	1,355,064
Net loss	(595,625)				(595,625)
Other comprehensive income	$ (1,969)			(1,969)
Ending balance (in shares) at Dec. 31, 2021	173,674,067	173,674,067
Ending balance at Dec. 31, 2021	$ 3,387,636	$ 1,738	6,028,861	(1,443)	(2,641,520)
Increase (Decrease) in Stockholders' Equity
Exercise of common stock options (in shares)	706,593	706,134
Exercise of common stock options	$ 6,524	$ 6	6,518
Issuance of common stock to fund the Company's 401(k) match (in shares)		391,129
Issuance of common stock to fund the Company’s 2019 401(k) match	29,202	$ 4	29,198
Compensation expense related to issuance of stock options and restricted stock awards (in shares)		2,220,510
Compensation expense related to issuance of stock options and restricted stock awards	206,823	$ 22	206,801
Purchase of employee stock purchase plan shares (in shares)		668,605
Purchase of employee stock purchase plan shares	25,491	$ 7	25,484
Issuance of common stock to fund business combinations (in shares)		265,186
Issuance of common stock for business combinations and asset acquisitions	14,792	$ 3	14,789
Other	(7)		(7)
Net loss	(623,506)				(623,506)
Other comprehensive income	$ (3,793)			(3,793)
Ending balance (in shares) at Dec. 31, 2022	177,925,631	177,925,631
Ending balance at Dec. 31, 2022	$ 3,043,162	$ 1,780	$ 6,311,644	$ (5,236)	$ (3,265,026)