Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Cash flows from operating activities:
Net loss	$ (105,697)	$ (82,939)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	16,006	6,375
Loss on disposal of property, plant and equipment	272	82
Unrealized loss on revaluation of marketable equity securities	669	0
Deferred tax benefit	(1,918)	(520)
Stock-based compensation	29,560	16,166
Loss on settlement of convertible notes	7,954	10,558
Amortization of convertible note debt discount and issuance costs	14,553	9,079
Amortization of deferred financing costs and other liabilities	(1,073)	(425)
Amortization of premium on short-term investments	53	(1,173)
Amortization of acquired intangible assets	23,339	760
Non-cash lease expense	10,190	877
Changes in assets and liabilities:
Accounts receivable, net	(6,322)	(11,856)
Inventory	(7,469)	(5,121)
Operating lease liabilities	(2,210)	(4,721)
Accounts payable and accrued liabilities	(18,296)	(2,216)
Other assets and liabilities	(9,438)	(9,080)
Net cash used in operating activities	(49,827)	(74,154)
Cash flows from investing activities:
Purchases of marketable securities	(425,168)	(262,887)
Maturities and sales of marketable securities	39,143	232,482
Purchases of property, plant and equipment	(12,685)	(10,657)
Business combination, net of cash acquired	(6,807)	0
Other investing activities	(330)	(140)
Net cash used in investing activities	(405,847)	(41,202)
Cash flows from financing activities:
Proceeds from issuance of convertible notes, net	1,125,547	729,536
Proceeds from exercise of common stock options	4,300	3,650
Payments on settlement of convertible notes	(150,054)	(493,355)
Proceeds from construction loan	0	295
Payments on mortgage payable	(313)	0
Net cash provided by financing activities	979,480	240,126
Net increase in cash and cash equivalents	523,806	124,770
Cash and cash equivalents, beginning of period	177,528	160,430
Cash and cash equivalents, end of period	701,334	285,200
Supplemental disclosure of non-cash investing and financing activities:
Property, plant and equipment acquired but not paid	13,631	42,119
Unrealized gain (loss) on available-for-sale investments, before tax	(1,642)	2,176
Issuance of 136,559 and 86,532 shares of common stock to fund the Company’s 401(k) matching contribution for 2019 and 2018, respectively	12,007	7,409
Issuance of 2,158,991 shares of common stock upon settlement of convertible notes	0	182,435
Retirement of equity component of convertible notes settled	(64,199)	(300,768)
Issuance of common stock for business combinations	28,597	0
Supplemental Cash Flow Information [Abstract]
Interest paid	$ 3,725	$ 1,712