<SEC-DOCUMENT>0001047469-16-014591-index.html : 20160801
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<ACCEPTANCE-DATETIME>20160801162731
ACCESSION NUMBER:		0001047469-16-014591
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20160801
DATE AS OF CHANGE:		20160801

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
		CENTRAL INDEX KEY:			0001124140
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				204782291
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-212701
		FILM NUMBER:		161797581

	BUSINESS ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719
		BUSINESS PHONE:		608-284-5700

	MAIL ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXACT CORP
		DATE OF NAME CHANGE:	20000919
</SEC-HEADER>
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<SEQUENCE>1
<FILENAME>a2229295z424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: a2229295z424b5.htm

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<SEQUENCE>2
<FILENAME>g1801.jpg
<DESCRIPTION>G1801.JPG
<TEXT>
Document 2 - file: g1801.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g400542.jpg
<DESCRIPTION>G400542.JPG
<TEXT>
Document 3 - file: g400542.jpg

</DOCUMENT>
</SEC-DOCUMENT>