<SEC-DOCUMENT>0001047469-16-014491-index.html : 20160727
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<ACCEPTANCE-DATETIME>20160727160613
ACCESSION NUMBER:		0001047469-16-014491
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20160727
DATE AS OF CHANGE:		20160727
EFFECTIVENESS DATE:		20160727

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
		CENTRAL INDEX KEY:			0001124140
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				204782291
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-212701
		FILM NUMBER:		161786784

	BUSINESS ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719
		BUSINESS PHONE:		608-284-5700

	MAIL ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXACT CORP
		DATE OF NAME CHANGE:	20000919
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<TYPE>S-3ASR
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Document 1 - file: a2229258zs-3asr.htm

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<DOCUMENT>
<TYPE>EX-4.8
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<FILENAME>a2229258zex-4_8.htm
<DESCRIPTION>EX-4.8
<TEXT>
Document 2 - file: a2229258zex-4_8.htm

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<DOCUMENT>
<TYPE>EX-5
<SEQUENCE>3
<FILENAME>a2229258zex-5.htm
<DESCRIPTION>EX-5
<TEXT>
Document 3 - file: a2229258zex-5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-12
<SEQUENCE>4
<FILENAME>a2229258zex-12.htm
<DESCRIPTION>EX-12
<TEXT>
Document 4 - file: a2229258zex-12.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>5
<FILENAME>a2229258zex-23_2.htm
<DESCRIPTION>EX-23.2
<TEXT>
Document 5 - file: a2229258zex-23_2.htm

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<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g1801.jpg
<DESCRIPTION>G1801.JPG
<TEXT>
Document 6 - file: g1801.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>g154782kqi001.jpg
<DESCRIPTION>G154782KQI001.JPG
<TEXT>
Document 7 - file: g154782kqi001.jpg

</DOCUMENT>
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