EXHIBIT 23.1


                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

The Board of Directors
EXACT Sciences Corporation

We consent to the reference to our firm under the caption "Experts" in the
Registration Statement (Form S-3) and related Prospectus of EXACT Sciences
Corporation for the registration of its securities with an aggregate public
offering price of $100,000,000 and to the incorporation by reference therein of
our report dated January 17, 2003, with respect to the consolidated financial
statements of EXACT Sciences Corporation included in its Annual Report (Form
10-K) for the year ended December 31, 2002, filed with the Securities and
Exchange Commission.



                                            /s/ ERNST & YOUNG LLP


Boston, Massachusetts
September 9, 2003