Restructuring - Additional Information (Detail) $ in Thousands	1 Months Ended			3 Months Ended		9 Months Ended	12 Months Ended
	May 31, 2022 USD ($)	Mar. 31, 2022 Employee	Nov. 30, 2021	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($)	Sep. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)
Restructuring Cost And Reserve [Line Items]
Percent of employees terminated			35.00%
Severance costs and expenses							$ 400
Charges related to write off of prepaid manufacturing cost							3,800
Restructuring liability							$ 200
Number of employees terminated | Employee		22
Remaining number of full time employees | Employee		5
Gain (loss) on disposal						$ 57,245
Proceeds from the sale of complement portfolio to Vertex						55,000
Dren Bio, Inc. and Copia Scientific, LLC
Restructuring Cost And Reserve [Line Items]
Total consideration for sales agreements				$ 400
Gain (loss) on disposal				$ (200)
Vertex Pharmaceuticals Incorporated
Restructuring Cost And Reserve [Line Items]
Gain (loss) on disposal	$ 57,400
Proceeds from the sale of complement portfolio to Vertex	60,000
Upfront payment received	55,000
Post closing indemnification obligation	$ 5,000
Transaction costs						$ 2,600
Operating Expense
Restructuring Cost And Reserve [Line Items]
Severance and other charges					$ 1,000