Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Reconciliation of Federal Income Tax Rate to Company's Effective Tax Rate

The reconciliation of the federal statutory income tax rate to the Company’s effective tax rate for the years ended December 31, 2021 and 2020 are as follows:

	Year Ended December 31,
	2021			2020
Tax at statutory federal rate		-21.00	%		-21.00	%
State Tax (benefit)—net of federal benefit		0.00	%		0.00	%
Permanent differences		0.35	%		0.58	%
Tax credits		-5.86	%		-12.26	%
Derecognition due to Sec. 382 and 383 limitations		0.00	%		44.55	%
Change in valuation allowance		26.26	%		-12.25	%
Other		0.25	%		0.38	%
Effective tax rate		0.00	%		0.00	%

Components of the Company's Deferred Tax Assets (Liabilities)

Significant components of the Company’s deferred tax assets as of December 31, 2021 and 2020 consist of the following (in thousands):

	Year Ended December 31,
	2021			2020
Deferred tax assets:
Accruals and reserves	$	1,000		$	1,095
Net operating loss carry forwards		47,541			29,505
Tax credit carry forwards		12,939			7,789
Fixed and intangible assets		3			7
Valuation allowance		(61,483	)		(38,396	)
Net deferred tax assets:	$	—		$	—

Unrecognized Tax Benefits

A reconciliation of the beginning and ending balance of the unrecognized tax benefits is as follows (in thousands):

Beginning Balance at January 1, 2020	$	1,871
Increase/(Decrease) of unrecognized tax benefits taken    in prior years		(295	)
Increase/(Decrease) of unrecognized tax benefits    related to current year		1,379
Ending Balance at December 31, 2020	$	2,955
Increase/(Decrease) of unrecognized tax benefits taken    in prior years		—
Increase/(Decrease) of unrecognized tax benefits    related to current year		1,749
Ending Balance at December 31, 2021	$	4,704