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Summary of Option Activity Under Company's Equity Incentive Plans (Detail) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Number of Shares Underlying Outstanding Options      
Number of Shares Underlying Outstanding Options, Beginning Balance 140,990 146,634  
Number of Shares Underlying Outstanding Options, Options granted 742,000 14,706  
Number of Shares Underlying Outstanding Options, Fractional shares written off in connection with the merger [1]   (4)  
Number of Shares Underlying Outstanding Options, Options canceled (141) (13,773)  
Number of Shares Underlying Outstanding Options, Options forfeited (61,108) (6,573)  
Number of Shares Underlying Outstanding Options, Ending Balance 821,741 140,990 146,634
Number of Shares Underlying Outstanding Options, Exercisable- December 31, 2017 161,240    
Number of Shares Underlying Outstanding Options, Vested and expected to vest - December 31, 2017 821,741    
Shares Available to be granted - December 31, 2017 354,886    
Weighted- Average Exercise Price      
Weighted- Average Exercise Price, Beginning Balance $ 128.25 $ 147.45  
Weighted- Average Exercise Price, Options granted 4.56 23.70  
Weighted- Average Exercise Price, Options canceled 41.91 259.05  
Weighted- Average Exercise Price, Options forfeited 165.63 64.95  
Weighted- Average Exercise Price, Ending Balance 13.69 $ 128.25 $ 147.45
Weighted- Average Exercise Price, Exercisable - December 31, 2017 45.34    
Weighted- Average Exercise Price, Vested and expected to vest - December 31, 2017 $ 13.69    
Weighted-Average Remaining Contractual Term (Years)      
Weighted-Average Remaining Contractual Term (Years), Outstanding Balance 9 years 2 months 1 day 3 years 11 months 4 days 5 years 6 months 3 days
Aggregate Intrinsic Value      
Aggregate Intrinsic Value, Outstanding $ 6,376   $ 16
[1] In connection with the merger, the Company assumed stock options covering an aggregate of 94,721 shares of common stock. The Company also assumed 190 shares of Restricted Stock Awards which vested in two equal annual installments beginning on December 31, 2015 and fully vesting on December 31, 2016 and excludes 4 aggregate fractional shares written off as a result of the conversion ratio applied to options assumed in the merger. Total stock-based compensation related to these restricted stock awards was $0.02 million for year ended December 31, 2016.