X0609 4 2026-06-10 0001124105 GYRE THERAPEUTICS, INC. GYRE 0001488668 Epstein David M. false C/O GYRE THERAPEUTICS, INC. 12730 HIGH BLUFF DRIVE, SUITE 250 SAN DIEGO CA 92130 true false Stock Option (Right to Buy) 5.95 2026-06-10 4 A 0 40000 0 A 2036-06-10 Common Stock 40000 40000 D This option represents a right to purchase a total of 40,000 shares of the Issuer's common stock, which will vest in 12 equal monthly installments through June 10, 2027, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Thomas Eastling, as attorney-in-fact for David M. Epstein 2026-06-30