X0609 4 2026-05-18 0001124105 GYRE THERAPEUTICS, INC. GYRE 0001985496 Ye Weiguo false C/O GYRE THERAPEUTICS, INC. 12730 HIGH BLUFF DRIVE, SUITE 250 SAN DIEGO CA 92130 true Chief Operating Officer false Common Stock 2026-05-18 4 M 0 200 0.75 A 700200 D Common Stock 2026-05-18 4 S 0 200 6.62 D 700000 D Common Stock 2026-05-19 4 M 0 9120 0.75 A 709120 D Common Stock 2026-05-19 4 S 0 9120 6.37 D 700000 D Stock Option (Right to Buy) 0.75 2026-05-18 4 M 0 200 0 D 2030-10-31 Common Stock 200 936235 D Stock Option (Right to Buy) 0.75 2026-05-19 4 M 0 9120 0 D 2030-10-31 Common Stock 9120 927115 D The price reported represents the weighted average sale price per share. The shares were sold in multiple transactions at prices ranging from $6.6102 to $6.6215. Upon request by the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. The price reported represents the weighted average sale price per share. The shares were sold in multiple transactions at prices ranging from $6.3002 to $6.4119. Upon request by the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. These options are vested in full. /s/ Weiguo Ye 2026-05-20