X0609 4 2026-05-05 0001124105 GYRE THERAPEUTICS, INC. GYRE 0001959160 Luo Ying false C/O GYRE THERAPEUTICS, INC. 12730 HIGH BLUFF DRIVE, SUITE 250 SAN DIEGO CA 92130 true true Chief Executive Officer true Common Stock 2026-05-05 4 S 0 179 8.01 D 2575362 I By Spouse Common Stock 2026-05-06 4 S 0 10136 8.04 D 2565226 I By Spouse This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on March 13, 2025. The price reported represents the weighted average sale price per share. The shares were sold in multiple transactions at prices ranging from $8.00 to $8.071. Upon request by the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. /s/ Thomas Eastling, as attorney-in-fact for Ying Luo 2026-05-07