X0508 4 2025-08-18 0001124105 GYRE THERAPEUTICS, INC. GYRE 0002083482 Weng Dan C/O GYRE THERAPEUTICS, INC. 12770 HIGH BLUFF DRIVE, SUITE 150 SAN DIEGO CA 92130 true false Stock Option (Right to Buy) 7.85 2025-08-18 4 A 0 52000 0 A 2035-08-18 Common Stock 52000 52000 D This option represents a right to purchase a total of 52,000 shares of the Issuer's common stock, which will vest in 36 equal monthly installments through August 18, 2028, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Ruoyu Chen, as attorney-in-fact for Dan Weng 2025-08-26