X0508 4 2025-06-04 0001124105 GYRE THERAPEUTICS, INC. GYRE 0001488668 Epstein David M. C/O GYRE THERAPEUTICS, INC. 12770 HIGH BLUFF DRIVE, SUITE 150 SAN DIEGO CA 92130 true false Stock Option (Right to Buy) 8.58 2025-06-04 4 A 0 26000 0 A 2035-06-04 Common Stock 26000 26000 D This option represents a right to purchase a total of 26,000 shares of the Issuer's common stock, which will vest in 12 equal monthly installments through June 4, 2026, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Ruoyu Chen, as attorney-in-fact for David M. Epstein 2025-06-06