X0508 4 2024-08-14 0001124105 GYRE THERAPEUTICS, INC. GYRE 0001982080 Chen Ruoyu C/O GYRE THERAPEUTICS, INC. 12770 HIGH BLUFF DRIVE, SUITE 150 SAN DIEGO CA 92130 true Chief Financial Officer false Stock Option (Right to Buy) 9.98 2024-08-14 4 A 0 50000 0 A 2034-08-14 Common Stock 50000 50000 D This option represents a right to purchase a total of 50,000 shares of the Issuer's common stock, 25% of which will vest on August 14, 2025, with the remaining vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Ruoyu Chen 2024-08-16