X0306 4 2017-03-22 0001123979 SENOMYX INC SNMX 0001286100 POYHONEN JOHN 4767 NEXUS CENTRE DR. SAN DIEGO CA 92121 1 1 President & CEO Common Stock 2017-03-22 4 P 0 35000 0.9779 A 143293 D Common Stock 2017-03-23 4 P 0 15000 0.9867 A 158293 D The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9576 to $0.9995, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4. Of this amount, 108,293 shares of common stock are held indirectly by a trust. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9787 to $0.9928, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (3) to this Form 4. /s/ Catherine C. Lee, Attorney-in-fact 2017-03-23