X0306 4 2014-09-17 0001123979 SENOMYX INC SNMX 0001473301 KARANEWSKY DONALD 4767 NEXUS CENTRE DR. SAN DIEGO CA 92121 1 Senior V.P. & CSO Common Stock 2014-09-17 4 M 0 20000 3.21 A 20000 D Common Stock 2014-09-17 4 S 0 20000 8.6139 D 0 D Stock option (right to buy) 3.21 2014-09-17 4 M 0 20000 0 D 2019-02-15 Common Stock 20000 44200 D Reported transaction occurred pursuant to Rule 10B5-1 Plan. The weighted average sale price for the transaction reported was $8.6139, and the range of prices were between $8.51 and $8.91. Upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price will be provided. The Reporting Person also holds outstanding options to purchase 712,600 shares of Common Stock The shares subject to the option are fully vested. /s/ Dave Humphrey, Attorney-in-fact 2014-09-19