X0306 4 2020-09-11 0 0001404281 Novus Therapeutics, Inc. NVUS 0001123343 LYONS GARY A C/O NOVUS THERAPEUTICS, INC. 19900 MACARTHUR BLVD., SUITE 550 IRVINE CA 92612 1 0 0 0 Stock Option (Right to Buy) 500.00 2020-09-11 4 A 0 1167.21 0.00 A 2030-09-11 Series X1 Convertible Preferred Stock 1167.21 1167.21 D This option represents a right to purchase a total of 1,167.21 shares of the Issuer's Series X1 Convertible Preferred Stock, which will vest in equal monthly installments over two years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The Reporting Person's ability to exercise the option will be subject to stockholder approval under Nasdaq Marketplace Rule 5635(c). Each share of Series X1 Convertible Preferred Stock will be convertible into 1,000 shares of Common Stock upon receipt of the requisite approval of the stockholders of the Issuer. /s/ Ryan A. Murr, as attorney-in-fact for Gary A. Lyons 2020-09-15