The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109   374,630 6,715 SH   SOLE   0 0 6,715
ABBOTT LABS COM 002824100   4,143,863 40,923 SH   SOLE   0 0 40,923
ABBVIE INC COM 00287Y109   13,805,267 86,624 SH   SOLE   0 0 86,624
ACTIVISION BLIZZARD INC COM 00507V109   18,082,171 211,265 SH   SOLE   0 0 211,265
ADOBE SYSTEMS INCORPORATED COM 00724F101   9,588,391 24,881 SH   SOLE   0 0 24,881
ADVANCED MICRO DEVICES INC COM 007903107   11,418,067 116,499 SH   SOLE   0 0 116,499
AIR PRODS & CHEMS INC COM 009158106   1,960,495 6,826 SH   SOLE   0 0 6,826
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   2,146,291 21,005 SH   SOLE   0 0 21,005
ALIGN TECHNOLOGY INC COM 016255101   25,443,090 76,145 SH   SOLE   0 0 76,145
ALPHABET INC CAP STK CL C 02079K107   48,048,416 462,004 SH   SOLE   0 0 462,004
ALPHABET INC CAP STK CL A 02079K305   154,542,555 1,489,854 SH   SOLE   0 0 1,489,854
AMAZON COM INC COM 023135106   162,361,035 1,571,895 SH   SOLE   0 0 1,571,895
AMEDISYS INC COM 023436108   771,613 10,491 SH   SOLE   0 0 10,491
AMETEK INC COM 031100100   4,977,698 34,251 SH   SOLE   0 0 34,251
AON PLC SHS CL A G0403H108   4,695,614 14,893 SH   SOLE   0 0 14,893
APELLIS PHARMACEUTICALS INC COM 03753U106   484,212 7,341 SH   SOLE   0 0 7,341
APPLE INC COM 037833100   45,253,837 274,432 SH   SOLE   0 0 274,432
ARK ETF TR INNOVATION ETF 00214Q104   4,647,168 115,200 SH   SOLE   0 0 115,200
ARK ETF TR FINTECH INNOVA 00214Q708   4,721,310 251,000 SH   SOLE   0 0 251,000
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   240,995 9,488 SH   SOLE   0 0 9,488
AUTODESK INC COM 052769106   2,215,863 10,645 SH   SOLE   0 0 10,645
BANK AMERICA CORP COM 060505104   5,799,737 202,788 SH   SOLE   0 0 202,788
BAXTER INTL INC COM 071813109   7,596,320 187,286 SH   SOLE   0 0 187,286
BECTON DICKINSON & CO COM 075887109   990,160 4,000 SH   SOLE   0 0 4,000
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702   14,002,411 45,349 SH   SOLE   0 0 45,349
BERKSHIRE HATHAWAY INC DEL CL A 084670108   44,232,000 95 SH   SOLE   0 0 95
BIOGEN INC COM 09062X103   999,796 3,596 SH   SOLE   0 0 3,596
BLACKSTONE INC COM 09260D107   210,816 2,400 SH   SOLE   0 0 2,400
BOOKING HOLDINGS INC COM 09857L108   11,869,535 4,475 SH   SOLE   0 0 4,475
BOSTON SCIENTIFIC CORP COM 101137107   964,478 19,278 SH   SOLE   0 0 19,278
BRISTOL-MYERS SQUIBB CO COM 110122108   779,738 11,250 SH   SOLE   0 0 11,250
BROADCOM INC COM 11135F101   8,703,773 13,567 SH   SOLE   0 0 13,567
CAMECO CORP COM 13321L108   29,157,159 1,115,000 SH   SOLE   0 0 1,115,000
CASTLE BIOSCIENCES INC COM 14843C105   289,453 12,740 SH   SOLE   0 0 12,740
CATALENT INC COM 148806102   274,602 4,179 SH   SOLE   0 0 4,179
CHEVRON CORP NEW COM 166764100   7,277,425 44,603 SH   SOLE   0 0 44,603
CHIPOTLE MEXICAN GRILL INC COM 169656105   34,471,584 20,179 SH   SOLE   0 0 20,179
CINTAS CORP COM 172908105   57,252,023 123,740 SH   SOLE   0 0 123,740
CME GROUP INC COM 12572Q105   3,598,661 18,790 SH   SOLE   0 0 18,790
COCA COLA CO COM 191216100   1,677,912 27,050 SH   SOLE   0 0 27,050
COLGATE PALMOLIVE CO COM 194162103   20,216,327 269,013 SH   SOLE   0 0 269,013
CONSTELLATION BRANDS INC CL A 21036P108   1,027,348 4,548 SH   SOLE   0 0 4,548
COOPER COS INC COM NEW 216648402   446,165 1,195 SH   SOLE   0 0 1,195
COSTCO WHSL CORP NEW COM 22160K105   43,332,033 87,210 SH   SOLE   0 0 87,210
DANAHER CORPORATION COM 235851102   66,605,351 264,265 SH   SOLE   0 0 264,265
DAVITA INC COM 23918K108   243,330 3,000 SH   SOLE   0 0 3,000
DEUTSCHE BANK A G NAMEN AKT D18190898   266,615 26,230 SH   SOLE   0 0 26,230
DEXCOM INC COM 252131107   273,372 2,353 SH   SOLE   0 0 2,353
DISNEY WALT CO COM 254687106   5,547,202 55,400 SH   SOLE   0 0 55,400
DROPBOX INC CL A 26210C104   466,041 21,556 SH   SOLE   0 0 21,556
ECOLAB INC COM 278865100   2,077,402 12,550 SH   SOLE   0 0 12,550
EDWARDS LIFESCIENCES CORP COM 28176E108   677,890 8,194 SH   SOLE   0 0 8,194
ELECTRONIC ARTS INC COM 285512109   11,173,183 92,762 SH   SOLE   0 0 92,762
ENPHASE ENERGY INC COM 29355A107   782,452 3,721 SH   SOLE   0 0 3,721
EOG RES INC COM 26875P101   3,823,942 33,359 SH   SOLE   0 0 33,359
ERMENEGILDO ZEGNA N V ORD SHS N30577105   310,992 22,800 SH   SOLE   0 0 22,800
ETSY INC COM 29786A106   487,403 4,378 SH   SOLE   0 0 4,378
EXACT SCIENCES CORP COM 30063P105   9,682,861 142,794 SH   SOLE   0 0 142,794
FERRARI N V COM N3167Y103   381,889 1,410 SH   SOLE   0 0 1,410
FIDELITY NATL INFORMATION SV COM 31620M106   1,542,157 28,385 SH   SOLE   0 0 28,385
GILEAD SCIENCES INC COM 375558103   1,250,773 15,075 SH   SOLE   0 0 15,075
GLOBAL BLUE GROUP HOLDING AG ORD SHS H33700107   771,426 128,571 SH   SOLE   0 0 128,571
HCA HEALTHCARE INC COM 40412C101   373,635 1,417 SH   SOLE   0 0 1,417
HDFC BANK LTD SPONSORED ADS 40415F101   2,440,189 36,601 SH   SOLE   0 0 36,601
HOME DEPOT INC COM 437076102   1,506,292 5,104 SH   SOLE   0 0 5,104
HONEYWELL INTL INC COM 438516106   15,538,629 81,303 SH   SOLE   0 0 81,303
ICON PLC SHS G4705A100   324,230 1,518 SH   SOLE   0 0 1,518
IDEXX LABS INC COM 45168D104   44,583,132 89,152 SH   SOLE   0 0 89,152
ILLUMINA INC COM 452327109   1,359,022 5,844 SH   SOLE   0 0 5,844
INFOSYS LTD SPONSORED ADR 456788108   1,966,308 112,747 SH   SOLE   0 0 112,747
INSULET CORP COM 45784P101   305,564 958 SH   SOLE   0 0 958
INTEL CORP COM 458140100   532,521 16,300 SH   SOLE   0 0 16,300
INTERCONTINENTAL EXCHANGE IN COM 45866F104   7,776,905 74,570 SH   SOLE   0 0 74,570
INTERNATIONAL BUSINESS MACHS COM 459200101   768,187 5,860 SH   SOLE   0 0 5,860
INTERNATIONAL FLAVORS&FRAGRA COM 459506101   474,514 5,160 SH   SOLE   0 0 5,160
INTUIT COM 461202103   11,502,414 25,800 SH   SOLE   0 0 25,800
INTUITIVE SURGICAL INC COM NEW 46120E602   46,521,087 182,100 SH   SOLE   0 0 182,100
INVESCO QQQ TR UNIT SER 1 46090E103   22,070,677 68,771 SH   SOLE   0 0 68,771
IOVANCE BIOTHERAPEUTICS INC COM 462260100   231,966 37,965 SH   SOLE   0 0 37,965
IRHYTHM TECHNOLOGIES INC COM 450056106   420,586 3,391 SH   SOLE   0 0 3,391
ISHARES INC MSCI JPN ETF NEW 46434G822   248,317 4,231 SH   SOLE   0 0 4,231
ISHARES INC MSCI WORLD ETF 464286392   347,833 2,956 SH   SOLE   0 0 2,956
ISHARES TR RUS 1000 VAL ETF 464287598   5,157,808 33,875 SH   SOLE   0 0 33,875
ISHARES TR CORE S&P500 ETF 464287200   14,424,797 35,090 SH   SOLE   0 0 35,090
ISHARES TR MSCI INDIA ETF 46429B598   384,705 9,774 SH   SOLE   0 0 9,774
ISHARES TR RUS 1000 GRW ETF 464287614   210,124 860 SH   SOLE   0 0 860
ISHARES TR CORE US AGGBD ET 464287226   330,008 3,312 SH   SOLE   0 0 3,312
ISHARES TR S&P 500 VAL ETF 464287408   11,744,706 77,390 SH   SOLE   0 0 77,390
ISHARES TR IBOXX INV CP ETF 464287242   251,117 2,291 SH   SOLE   0 0 2,291
JOHNSON & JOHNSON COM 478160104   4,064,410 26,222 SH   SOLE   0 0 26,222
JPMORGAN CHASE & CO COM 46625H100   26,467,264 203,110 SH   SOLE   0 0 203,110
LAUDER ESTEE COS INC CL A 518439104   26,944,979 109,328 SH   SOLE   0 0 109,328
LILLY ELI & CO COM 532457108   18,272,348 53,207 SH   SOLE   0 0 53,207
LINDE PLC SHS G54950103   20,045,039 56,395 SH   SOLE   0 0 56,395
LOCKHEED MARTIN CORP COM 539830109   756,368 1,600 SH   SOLE   0 0 1,600
LOGITECH INTL S A SHS H50430232   844,794 14,534 SH   SOLE   0 0 14,534
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100   2,170,361 23,116 SH   SOLE   0 0 23,116
MASTERCARD INCORPORATED CL A 57636Q104   19,121,907 52,618 SH   SOLE   0 0 52,618
MCDONALDS CORP COM 580135101   61,297,502 219,225 SH   SOLE   0 0 219,225
MEDTRONIC PLC SHS G5960L103   17,664,084 219,103 SH   SOLE   0 0 219,103
MERCK & CO INC COM 58933Y105   26,688,463 250,855 SH   SOLE   0 0 250,855
META PLATFORMS INC CL A 30303M102   33,292,383 157,084 SH   SOLE   0 0 157,084
MICRON TECHNOLOGY INC COM 595112103   4,039,944 66,953 SH   SOLE   0 0 66,953
MICROSOFT CORP COM 594918104   190,075,037 659,296 SH   SOLE   0 0 659,296
MODERNA INC COM 60770K107   52,703,127 343,164 SH   SOLE   0 0 343,164
MONDELEZ INTL INC CL A 609207105   20,332,234 291,627 SH   SOLE   0 0 291,627
MOODYS CORP COM 615369105   13,261,683 43,336 SH   SOLE   0 0 43,336
MORGAN STANLEY COM NEW 617446448   224,505 2,557 SH   SOLE   0 0 2,557
NATERA INC COM 632307104   617,271 11,118 SH   SOLE   0 0 11,118
NEOGEN CORP COM 640491106   1,332,514 71,950 SH   SOLE   0 0 71,950
NETFLIX INC COM 64110L106   392,120 1,135 SH   SOLE   0 0 1,135
NIKE INC CL B 654106103   26,677,266 217,525 SH   SOLE   0 0 217,525
NOVAGOLD RES INC COM NEW 66987E206   24,738,606 4,000,000 SH   SOLE   0 0 4,000,000
NUTRIEN LTD COM 67077M108   1,486,806 20,160 SH   SOLE   0 0 20,160
NVIDIA CORPORATION COM 67066G104   41,459,950 149,260 SH   SOLE   0 0 149,260
OTIS WORLDWIDE CORP COM 68902V107   7,276,040 86,209 SH   SOLE   0 0 86,209
PALO ALTO NETWORKS INC COM 697435105   3,182,457 15,933 SH   SOLE   0 0 15,933
PARKER-HANNIFIN CORP COM 701094104   359,974 1,071 SH   SOLE   0 0 1,071
PAYPAL HLDGS INC COM 70450Y103   2,784,948 36,673 SH   SOLE   0 0 36,673
PENUMBRA INC COM 70975L107   376,510 1,351 SH   SOLE   0 0 1,351
PEPSICO INC COM 713448108   60,010,608 329,186 SH   SOLE   0 0 329,186
PERRIGO CO PLC SHS G97822103   310,276 8,650 SH   SOLE   0 0 8,650
PFIZER INC COM 717081103   2,277,415 55,819 SH   SOLE   0 0 55,819
PROCTER AND GAMBLE CO COM 742718109   8,660,895 58,248 SH   SOLE   0 0 58,248
PROSHARES TR S&P 500 DV ARIST 74348A467   791,689 8,677 SH   SOLE   0 0 8,677
PURE STORAGE INC CL A 74624M102   277,600 10,882 SH   SOLE   0 0 10,882
RANGE RES CORP COM 75281A109   13,732,636 518,800 SH   SOLE   0 0 518,800
REPLIGEN CORP COM 759916109   372,076 2,210 SH   SOLE   0 0 2,210
RIO TINTO PLC SPONSORED ADR 767204100   205,800 3,000 SH   SOLE   0 0 3,000
ROCKWELL AUTOMATION INC COM 773903109   640,014 2,181 SH   SOLE   0 0 2,181
ROLLINS INC COM 775711104   2,127,951 56,700 SH   SOLE   0 0 56,700
ROYALTY PHARMA PLC SHS CLASS A G7709Q104   1,801,500 50,000 SH   SOLE   0 0 50,000
SALESFORCE INC COM 79466L302   24,406,124 122,165 SH   SOLE   0 0 122,165
SCHLUMBERGER LTD COM STK 806857108   10,045,664 204,596 SH   SOLE   0 0 204,596
SEA LTD SPONSORD ADS 81141R100   2,058,765 23,787 SH   SOLE   0 0 23,787
SEAGEN INC COM 81181C104   384,693 1,900 SH   SOLE   0 0 1,900
SNOWFLAKE INC CL A 833445109   2,576,643 16,700 SH   SOLE   0 0 16,700
SOPHIA GENETICS SA ORDINARY SHARES H82027105   1,131,172 227,600 SH   SOLE   0 0 227,600
SPDR GOLD TR GOLD SHS 78463V107   8,230,426 44,921 SH   SOLE   0 0 44,921
SPDR S&P 500 ETF TR TR UNIT 78462F103   18,396,349 44,936 SH   SOLE   0 0 44,936
SPDR S&P MIDCAP 400 ETF TR UTSER1 S&PDCRP 78467Y107   201,242 439 SH   SOLE   0 0 439
SPDR SER TR S&P BIOTECH 78464A870   293,409 3,850 SH   SOLE   0 0 3,850
STARBUCKS CORP COM 855244109   4,174,051 40,085 SH   SOLE   0 0 40,085
STRYKER CORPORATION COM 863667101   664,860 2,329 SH   SOLE   0 0 2,329
T-MOBILE US INC COM 872590104   506,940 3,500 SH   SOLE   0 0 3,500
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   22,321,172 239,961 SH   SOLE   0 0 239,961
TANDEM DIABETES CARE INC COM NEW 875372203   258,970 6,377 SH   SOLE   0 0 6,377
TESLA INC COM 88160R101   3,209,614 15,471 SH   SOLE   0 0 15,471
TEXAS INSTRS INC COM 882508104   9,620,809 51,722 SH   SOLE   0 0 51,722
THERMO FISHER SCIENTIFIC INC COM 883556102   78,847,416 136,800 SH   SOLE   0 0 136,800
TJX COS INC NEW COM 872540109   694,975 8,869 SH   SOLE   0 0 8,869
UBS GROUP AG SHS H42097107   246,335 11,666 SH   SOLE   0 0 11,666
UNION PAC CORP COM 907818108   271,701 1,350 SH   SOLE   0 0 1,350
UNIQURE NV SHS N90064101   247,742 12,301 SH   SOLE   0 0 12,301
UNITEDHEALTH GROUP INC COM 91324P102   82,591,719 174,764 SH   SOLE   0 0 174,764
VANECK ETF TRUST OIL SERVICES ETF 92189H607   45,948,154 165,800 SH   SOLE   0 0 165,800
VANGUARD INDEX FDS S&P 500 ETF SHS 922908363   5,898,658 15,685 SH   SOLE   0 0 15,685
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858   775,236 19,189 SH   SOLE   0 0 19,189
VANGUARD SCOTTSDALE FDS SHRT TRM CORP BD 92206C409   368,343 4,832 SH   SOLE   0 0 4,832
VERIZON COMMUNICATIONS INC COM 92343V104   899,331 23,125 SH   SOLE   0 0 23,125
VERTEX PHARMACEUTICALS INC COM 92532F100   731,908 2,323 SH   SOLE   0 0 2,323
VISA INC COM CL A 92826C839   83,492,122 370,319 SH   SOLE   0 0 370,319
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308   181,277 16,420 SH   SOLE   0 0 16,420
WALMART INC COM 931142103   1,120,620 7,600 SH   SOLE   0 0 7,600
WEATHERFORD INTL PLC ORD SHS G48833118   30,683,950 517,000 SH   SOLE   0 0 517,000
WELLS FARGO CO NEW COM 949746101   16,234,657 434,314 SH   SOLE   0 0 434,314
WEYERHAEUSER CO MTN BE COM NEW 962166104   489,854 16,258 SH   SOLE   0 0 16,258
WISDOMTREE TR EUROPE HEDGED EQ 97717X701   859,423 10,454 SH   SOLE   0 0 10,454
WORKDAY INC CL A 98138H101   434,147 2,102 SH   SOLE   0 0 2,102
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105   13,906,140 43,730 SH   SOLE   0 0 43,730
ZIMMER BIOMET HOLDINGS INC COM 98956P102   4,140,602 32,048 SH   SOLE   0 0 32,048
ZOETIS INC CL A 98978V103   74,907,321 450,056 SH   SOLE   0 0 450,056