Exhibit 21

	State of
Subsidiary	Incorporation	Ownership (1)
Aetna Inc.	PA		—
Aetna Risk Indemnity Company Limited	Bermuda	100%	Owned by Aetna Inc.
Aetna Life Insurance Company	CT	100%	Owned by Aetna Inc.
Aetna Health and Life Insurance Company	CT	100%	Owned by Aetna Inc.
AUSHC Holdings, Inc.	CT	100%	Owned by Aetna Inc.
Aetna U.S. Healthcare Dental Plan Inc.	PA	100%	Owned by Aetna Inc.
Aetna U.S. Healthcare Dental Plan Inc.	NJ	100%	Owned by Aetna Inc.
Aetna U.S. Healthcare Dental Plan Inc.	DE	100%	Owned by Aetna Inc.
U.S. Health Insurance Company	NY	100%	Owned by Aetna Inc.
Primary Holdings, Inc.	DE	100%	Owned by Aetna Inc.
Corporate Health Insurance Company	PA	100%	Owned by Aetna Inc.
Aetna U.S. Healthcare Inc.	NJ	100%	Owned by Aetna Inc.
Aetna Health Inc.	NY	100%	Owned by Aetna Inc.
Aetna U.S. Healthcare Inc.	CT	100%	Owned by Aetna Inc.
Aetna U.S. Healthcare Inc.	MA	100%	Owned by Aetna Inc.
Aetna U.S. Healthcare Inc. (DE)	DE	100%	Owned by Aetna Inc.
Aetna U.S. Healthcare Inc.	NH	100%	Owned by Aetna Inc.
U.S. Healthcare Financial Services, LLC	DE	100%	Owned by Aetna Inc.
Prudential Health Care Plan, Inc.	TX	100%	Owned by Aetna Inc.
U.S. Managed Care, Inc.	MD	100%	Owned by Aetna Inc.
Criterion Communications, Inc.	DE	100%	Owned by Aetna Inc.
AE Fifteen Incorporated	CT	100%	Owned by Aetna Inc.
Aetna Business Resources, Inc.	CT	100%	Owned by Aetna Inc.
Luettgens Limited	CT	100%	Owned by Aetna Inc.
AE Housing Corp.	CT	100%	Owned by Aetna Inc.
ASI Wings, L.L.C.	DE	100%	Owned by Aetna Inc.
Aetna Health Management, Inc.	DE	100%	Owned by Aetna Inc.
NYLCare Health Plans, Inc.	DE	100%	Owned by Aetna Inc.
Aelan Inc.	CT	100%	Owned by Aetna Inc.
CMBS Holdings, L.L.C.	CT	99%	Owned by Aetna Life Insurance Company (2)
AHP Holdings, Inc.	CT	100%	Owned by Aetna Life Insurance Company
Circulation L.L.C.	CT	100%	Owned by Aetna Life Insurance Company
Azalea Mall, LLC	DE	100%	Owned by Aetna Life Insurance Company
BPC Equity, Inc.	DE	100%	Owned by Aetna Life Insurance Company (3)
BPC Equity, L.L.C.	DE	99%	Owned by Aetna Life Insurance Company (3)
ALEC Coinvestment Fund I L.L.C.	DE	100%	Owned by Aetna Life Insurance Company
Trumbull One, Inc.	CT	100%	Owned by Aetna Life Insurance Company
Trumbull Four, Inc.	CT	100%	Owned by Aetna Life Insurance Company
EBF Group L.L.C.	DE	22%	Owned by Aetna Life Insurance Company
Maxxim Coinvestment Fund IV, LLC	DE	100%	Owned by Aetna Life Insurance Company
Circon Coinvestment Fund IV, LLC	DE	100%	Owned by Aetna Life Insurance Company
Trevose Hospitality, Inc.	CT	100%	Owned by Aetna Life Insurance Company
Aetna Health Administrators, LLC	PA	100%	Owned by Aetna Life Insurance Company
Koll Center Newport A	CA	50%	Owned by Aetna Life Insurance Company
Koll Center Newport Number 8	CA	50%	Owned by Aetna Life Insurance Company
Koll Center Newport Number 9	CA	50%	Owned by Aetna Life Insurance Company
Koll Center Newport Number 10	CA	50%	Owned by Aetna Life Insurance Company
Koll Center Newport Number 11	CA	50%	Owned by Aetna Life Insurance Company
Koll Center Newport Number 14	CA	60%	Owned by Aetna Life Insurance Company
Mall Owners LLC	DE	50%	Owned by Aetna Life Insurance Company
PHPSNE Parent Corporation	DE	55%	Owned by AUSHC Holdings, Inc.
Primary Investments, Inc.	DE	100%	Owned by Primary Holdings, Inc.
U.S. Healthcare Advantage, LLC	DE	100%	Owned by U.S. Healthcare Financial Services, LLC
U.S. Patroitcare, Inc.	DE	100%	Owned by U.S. Healthcare Financial Services, LLC
@Credentials Inc.	DE	100%	Owned by U.S. Healthcare Financial Services, LLC
U.S. Health Aviation Corp.	PA	100%	Owned by U.S. Healthcare Financial Services, LLC
U.S. Healthcare Properties, Inc.	PA	100%	Owned by U.S. Healthcare Financial Services, LLC
Intelihealth Inc.	DE	100%	Owned by U.S. Healthcare Financial Services, LLC
Integrated Pharmacy Solutions, Inc.	FL	100%	Owned by U.S. Healthcare Financial Services, LLC

	State of
Subsidiary	Incorporation	Ownership (1)
Bentana Technologies, Inc.	CT	20%	Owned by U.S. Healthcare Financial Services, LLC (4)
Aetna U.S. Healthcare Inc.	OH	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare Inc.	MD	41%	Owned by Aetna Health Management, Inc. (5)
Aetna U.S. Healthcare, Inc.	FL	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare of California Inc.	CA	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare Inc.	LA	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare, Inc.	AZ	100%	Owned by Aetna Health Management, Inc.
Med Southwest, Inc.	TX	100%	Owned by Aetna Health Management, Inc.
Prudential Health Care Plan of California, Inc.	CA	100%	Owned by Aetna Health Management, Inc.
Prudential Dental Maintenance Organization, Inc.	TX	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare of Georgia, Inc.	GA	37%	Owned by Aetna Health Management, Inc. (6)
Aetna U.S. Healthcare Dental Plan of California Inc.	CA	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare of Illinois Inc.	IL	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare Inc.	TX	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare Inc.	TN	100%	Owned by Aetna Health Management, Inc.
Aetna U.S. Healthcare Dental Plan Inc.	TX	100%	Owned by Aetna Health Management, Inc.
VivaHealth Incorporated	CA	100%	Owned by Aetna Health Management, Inc.
AUSHC Holdings, Inc.	DE	100%	Owned by Aetna Health Management, Inc.
Informed Health, Inc.	DE	100%	Owned by Aetna Health Management, Inc.
Aetna Government Health Plans, Inc.	CA	100%	Owned by Aetna Health Management, Inc.
Aetna Dental Care of New Jersey, Inc.	NJ	100%	Owned by Aetna Health Management, Inc.
Lonestar Holding Co.	DE	100%	Owned by NYLCare Health Plans, Inc.
Aetna U.S. Healthcare Inc.	MD	44%	Owned by NYLCare Health Plans, Inc. (5)
Aetna U.S. Healthcare Inc.	ME	100%	Owned by NYLCare Health Plans, Inc.
The Ethix Corporation	DE	100%	Owned by NYLCare Health Plans, Inc.
New York Life and Health Insurance Company	DE	100%	Owned by NYLCare Health Plans, Inc.
NYLCare of Texas, Inc.	TX	100%	Owned by NYLCare Health Plans, Inc.
NYLCare of New England, Inc.	DE	100%	Owned by NYLCare Health Plans, Inc.
One Liberty Plaza Holdings, Inc.	DE	100%	Owned by NYLCare Health Plans, Inc.
Sanus of New York and New Jersey, Inc.	NY	100%	Owned by NYLCare Health Plans, Inc.
Sanus Preferred Providers West, Inc.	CA	100%	Owned by NYLCare Health Plans, Inc.
Managed Care Coordinators, Inc.	DE	100%	Owned by U.S. Healthcare Advantage, LLC
U. S. Quality Algorithms, Inc.	PA	100%	Owned by U.S. Healthcare Advantage, LLC
U.S. Healthcare, Inc.	MO	100%	Owned by Primary Investments, Inc.
United States Health Care Systems of Pennsylvania, Inc.	PA	100%	Owned by Primary Investments, Inc.
Aetna U.S. Healthcare Inc.	MD	15%	Owned by Primary Investments, Inc. (5)
Aetna U.S. Healthcare of the Carolinas Inc.	NC	100%	Owned by Primary Investments, Inc.
Aetna U.S. Healthcare of Georgia, Inc.	GA	63%	Owned by Primary Investments, Inc. (6)
U.S. Health Insurance Company	CT	100%	Owned by Primary Investments, Inc.
Aetna U.S. Healthcare Holdings, Inc.	DE	100%	Owned by Primary Investments, Inc.
Aetna U.S. Healthcare Inc.	WA	100%	Owned by Primary Investments, Inc.
Aetna U.S. Healthcare, Inc.	MI	100%	Owned by Primary Investments, Inc.
Aetna U.S. Healthcare, Inc.	OK	100%	Owned by Primary Investments, Inc.
Prudential Health Care Plan of Georgia, Inc.	GA	100%	Owned by Primary Investments, Inc.
Chickering Claims Administrators, Inc.	MA	47%	Owned by Primary Investments, Inc.
Aetna Insurance Company of Connecticut	CT	100%	Owned by AHP Holdings, Inc.
CMBS Holdings, Inc.	TX	100%	Owned by AHP Holdings, Inc.
CMBS Holdings, Inc. — II	CT	100%	Owned by AHP Holdings, Inc.
Aetna Affordable Housing, Inc.	CT	100%	Owned by AHP Holdings, Inc.
AE Fourteen, Inc.	CT	100%	Owned by AHP Holdings, Inc.
Aetna Life Assignment Company	CT	100%	Owned by AHP Holdings, Inc.
Aetna/Area Corporation	CT	100%	Owned by AHP Holdings, Inc.
Aetna Real Estate Properties, Inc.	CT	100%	Owned by AHP Holdings, Inc.
Bentana Technologies, Inc.	CT	80%	Owned by AHP Holdings, Inc. (4)
Aetna U.S. Healthcare of North Texas Inc.	TX	100%	Owned by Med Southwest, Inc.
Lone Star Health Plan, Inc.	TX	90%	Owned by Lonestar Holding Co. (7)

2

	State of
Subsidiary	Incorporation	Ownership (1)
ETHIX Northwest, Inc.	WA	100%	Owned by The Ethix Corporation
ETHIX Northwest Public Services, Inc.	WA	100%	Owned by The Ethix Corporation
Aetna U.S. Healthcare, Inc.	CO	100%	Owned by Aetna U.S. Healthcare Holdings, Inc.
Aetna U.S. Healthcare of Washington Inc.	WA	100%	Owned by Ethix Northwest, Inc.
Aetna Life & Casualty (Bermuda) Limited	Bermuda	100%	Owned by Aelan Inc.

(1)	Percentages are rounded to the nearest whole percent and are based on ownership of voting rights.
(2)	CMBS Holdings, Inc. — II owns 1% of CMBS Holdings, L.L.C.
(3)	BPC Equity, Inc. owns 1% of BPC Equity, L.L.C.
(4)	U.S. Healthcare Financial Services, LLC owns 20% and Aetna Health Management, Inc. owns 80% of Bentana Technologies, Inc.
(5)	NYLCare Health Plans, Inc. owns 44%, Aetna Health Management, Inc. owns 41% and Primary Investments, Inc. owns 15% of Aetna U.S. Healthcare Inc.
(6)	Primary Investments, Inc. owns 63% and Aetna Health Management, Inc. owns 37% of Aetna U.S. Healthcare of Georgia, Inc.
(7)	NYLCare Health Plans, Inc. owns 10% of this company.

3