X0306 4 2020-08-11 0 0001121702 YIELD10 BIOSCIENCE, INC. YTEN 0001197017 BRUM LYNNE H C/O YIELD10 BIOSCIENCE, INC. 19 PRESIDENTIAL WAY WOBURN MA 01801 0 1 0 0 VP Planning & Comms Common Stock 2020-08-11 4 F 0 587 6.55 D 3599 D Common Stock 2339 I By 401(k) Plan Represents shares withheld in payment of withholding taxes upon vesting of RSUs granted 2/11/20. Shares acquired as Company matching contributions under the Yield10 Bioscience, Inc. 401(k) Plan. /s/ Megan N. Gates, attorney-in-fact 2020-08-13