X0306 4 2020-05-19 1 0001121702 YIELD10 BIOSCIENCE, INC. YTEN 0001235215 SHAULSON JOSEPH H C/O YIELD10 BIOSCIENCE, INC. 19 PRESIDENTIAL WAY WOBURN MA 01801 1 0 0 0 The reporting person's term as a director of Yield10 Bioscience, Inc. ("Yield10") expired on May 19, 2020. As a result, the reporting person is no longer subject to Section 16 in connection with his transactions in the equity securities of Yield10 and therefore will no longer report any such transactions on Form 4 or Form 5. /s/ Megan N. Gates, attorney-in-fact 2020-05-19