X0306 4 2020-02-11 0 0001121702 YIELD10 BIOSCIENCE, INC. YTEN 0001230903 HAASER CHARLES B C/O YIELD10 BIOSCIENCE, INC. 19 PRESIDENTIAL WAY WOBURN MA 01801 0 1 0 0 VP Fin & Chief Accting Officer Common Stock 2020-02-11 4 A 0 4000 0 A 4055 D Common Stock 940 I By 401(k) Plan The securities awarded are in the form of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock. The RSUs will vest as to 50% of the shares on 8/11/20 and the remaining 50% on 2/11/21. All share numbers reported reflect the 1-for-40 reverse stock split effected on January 15, 2020. Shares acquired as Company matching contributions under the Yield10 Bioscience, Inc. 401(k) Plan. /s/ Megan N. Gates, attorney-in-fact 2020-02-13