Stock-Based Compensation - Stock Option Activity (Details) - Stock options - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Number of Shares
Balance at the beginning of the period (in shares)	339,108
Granted (in shares)	386,017
Exercised (in shares)	0	0
Forfeited (in shares)	(1,509)
Expired (in shares)	(851)
Balance at the end of the period (in shares)	722,765	339,108
Vested and expected to vest at the end of the period (in shares)	722,765
Options exercisable at the end of the period (in shares)	213,156
Weighted Average Exercise Price
Balance at the beginning of the period (in dollars per share)	$ 32.39
Granted (in dollars per share)	10.08
Exercised (in dollars per share)	0
Forfeited (in dollars per share)	12.92
Expired (in dollars per share)	1,131.62
Balance at the end of the period (in dollars per share)	19.22	$ 32.39
Vested and expected to vest at the end of the period (in dollars per share)	19.22
Exercisable at the end of the period (in dollars per share)	$ 43.15
Remaining Contractual Term
Balance	8 years 9 months 14 days
Vested and expected to vest	8 years 9 months 14 days
Exercisable	8 years 25 days
Aggregate Intrinsic Value
Balance	$ 0
Vested and expected to vest	0
Exercisable	$ 0