SB-2 1 form_sb-2.htm SB-2 SB-2

As filed with the Securities and Exchange Commission on July 1, 2005
                                                                                                                                Registration No. 333-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM SB-2

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

MINRAD INTERNATIONAL, INC.
( Name of small business issuer in its charter)

Delaware

3841

870299034

(State or other jurisdiction of

(Primary Standard Industrial

(I.R.S. Employer

incorporation or organization)

Classification Code)

Identification Number)

847 Main Street, Buffalo, NY 14203
(716) 855-1068
(Address and telephone number of principal executive offices and place of business)
________________________
William H. Burns, Jr.
Minrad International, Inc.
847 Main Street
Buffalo, New York 14203
(716) 855-1068
(Name, address and telephone of agent for service)
_____________________________
Copies to:
Ward B. Hinkle, Esq.
Hodgson Russ LLP
One M&T Plaza, Suite 2000
Buffalo, NY 14203
(716) 856-4000
_____________________________
Approximate date of proposed sale to the public: As soon as practicable after this registration statement becomes effective.

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ]

If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ]

If delivery of the prospectus is expected to be made pursuant to Rule 434, please check the following box. [ ]

CALCULATION OF REGISTRATION FEE

Title of Each Class of Securities to be Registered            Amount to be Registered (1) Proposed Maximum Offering Price
Per Unit         
Proposed Maximum Aggregate Offering Price Amount of Registration Fee             
         
Common Stock 9,964,686 $2.425 (2) $24,164,363 $2,827
Common Stock underlying preferred stock 8,619,000 $2.425 (2) $20,901,075 $2,445
Common Stock underlying warrants exercisable at $1.25 per share 320,108 $2.425 (3) $776,261 $90
Common Stock underlying warrants exercisable at $1.75 per share 465,697 $2.425 (3) $1,129,315 $132
Common Stock underlying warrants exercisable at $2.00 per share 563,000 $2.425 (3) $1,365,275 $159
Common Stock underlying warrants exercisable at $3.85 per share 3,659,500 $3.85 (3) $14,089,075 $1,648
Common Stock underlying convertible notes 1,528,570 $2.425 (2) $3,706,782 $433
         
Total 25,120,561     $7,734
         

_____________________________

1. We are registering the resale of shares of common stock by selling securityholders that we have issued or will issue to the selling securityholders as a result of private placements that we have made. Pursuant to Rule 416 under the Securities Act, the shares being registered hereunder include such indeterminate number of additional shares of Common Stock as may be issuable with respect to the shares being registered as a result of stock splits, stock dividends and similar changes as well as anti-dilution provisions of applicable to the convertible preferred stock, warrants and convertible notes.

2. Estimated solely for the purpose of calculating the registration fee in accordance with Rule 457 (c).  We have estimated the offering price to be $2.425 per share based on the reported average bid and asked price for shares of our stock in the over-the-counter market on June 24, 2005.

3. Represents the higher of: (a) the exercise prices of the warrants and (b) the offering price of securities of the same class as the common stock underlying the warrants calculated in accordance with rule 457(c), for the purpose of calculating the registration fee pursuant to Rule 457(g).

The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with section 8(a) of the Securities Act of 1933 or until the registration statement shall become effective on such date as the Commission, acting pursuant to said section 8(a), may determine.

The information in this prospectus is not complete and may be changed. The selling security holders will not sell these securities until after the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.

 

SUBJECT TO COMPLETION, DATED JULY 1, 2005

MINRAD International, Inc.
25,120,561 Shares of Common Stock

__________________

This prospectus relates to the offer for sale of 25,120,561 shares of our common stock by certain existing holders of the securities, referred to as selling securityholders throughout this document. The shares of common stock to be sold by the selling security holders include:

  •   
9,964,686 outstanding shares held by the selling securityholders;
  •   
8,619,000 shares issuable to the selling securityholders upon conversion of Series A preferred stock or as a result of common stock dividends on the Series A preferred stock;
  •   
5,008,305 shares issuable to the selling securityholders upon exercise of warrants; and
  •   
1,528,570 shares issuable to the selling securityholders upon conversion of obligations under convertible promissory notes.

          All of the shares being offered by this prospectus are being offered by the selling securityholders named in this prospectus. This offering is not being underwritten. We will not receive any of the proceeds from the sale of the shares of our common stock in this offering. If the warrants are exercised so that the underlying shares may be sold, we will receive the exercise price of the warrants, which vary from $1.25 to $3.85 per share. If the convertible notes are converted so that the underlying shares may be sold, we will be relieved of the debt obligations under the notes at a rate of $1.75 per share. The selling securityholders identified in this prospectus, or their pledgees, donees, transferees or other successors-in-interest, may offer the common stock or interests therein from time to time through public or private transactions at prevailing market prices, at prices related to prevailing market prices, or at privately negotiated prices. We will pay all expenses of registering this offering of securities.

          The common stock is traded in the over-the-counter market and prices are quoted on the NASD Bulletin Board under the symbol "MNRD.OB." On June 28, 2005, the last reported bid price was $2.50. Except under certain circumstances, the selling security holders will sell the shares from time to time through independent brokerage firms in the over-the-counter market at market prices prevailing at the time of sale.

          Investing in our stock involves substantial risks. See "Risk Factors" beginning on page __.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.
__________________

The date of this Prospectus is July , 2005

 

TABLE OF CONTENTS

  

Page

Summary    
Risk Factors    
Forward Looking Statements    
Where You Can Find Additional Information    
Use of Proceeds    
Dilution    
Selling Securityholders    
Plan of Distribution    
Business    
Management's Discussion and Analysis of Financial Condition  
     and Results of Operations
 
Directors and Executive Officers    
Certain Relationships and Related Party Transactions    
Stock Ownership of Certain Beneficial Owners and Management    
Market for Our Capital Stock    
Description of Capital Stock    
Legal Matters    
Experts    
Change of Accountants    
Index to Consolidated Financial Statements F-1

 

____________________________

 

You should rely only on the information contained in this prospectus. We have not authorized anyone to provide you with different information. We are not making an offer of these securities in any state where the offer is not permitted. You should not assume that the information contained in this prospectus is accurate as of any date other than the date on the front of this prospectus.

 

____________________________

i

 

SUMMARY

          The following summary highlights information contained elsewhere in this prospectus. This summary is not complete and may not contain all of the information that may be important to you. We encourage you to read carefully this entire prospectus, including the information under "Risk Factors" and the consolidated financial statements and the related notes included elsewhere in this prospectus before making an investment decision.

 

Our Company

          Through Minrad Inc., we operate an acute care business with two product lines: (1) real-time image guidance and (2) anesthesia and analgesia. We currently sell patented real-time image guidance technologies that enable medical professionals to improve the accuracy of interventional procedures and reduce the exposure to radiation. We recently launched SabreSourceTM, a second-generation real-time image guidance system. Our real-time image guidance products have broad applications in orthopedics, neurosurgery, interventional radiology and anesthesia. We manufacture and market generic inhalation anesthetics for use in connection with human and veterinary surgical interventions. We are also developing a drug/drug delivery system for conscious sedation, which, similar to nitrous oxide used in dental surgery, provides a patient with pain relief without loss of consciousness.

          Our business was organized in 1994 as a Delaware corporation under the name Minrad Inc. On December 16, 2004, the shareholders of Minrad completed the acquisition of Minrad International, Inc., a Nevada corporation formerly known as Technology Acquisition Corporation. We effected the acquisition through a reverse triangular merger, whereby Minrad merged with and became a wholly owned subsidiary of Minrad International. At the time of the merger, Minrad International was a publicly traded shell corporation -- a company without significant assets or operations whose common stock was registered under the Securities Exchange Act.

          Minrad International was re-incorporated in Delaware on April 25, 2005. Our executive offices are located at 847 Main Street, Buffalo, New York 14203, and our telephone number is (716) 855-1068. Our web site address is www.minrad.com. Information contained on our web site is not a part of this prospectus.

The Offering

Shares offered by selling securityholders

          The selling stock holders will offer and sell up to an aggregate of 25,120,561 shares of common stock (of which 9,964,686 are currently outstanding), an amount equal to about 88.4% of our currently outstanding common stock. For a list of the selling stockholders and the amount of shares that each of them expects to sell, see "Selling Securityholders."

          The offering is being made by the selling securityholders for their benefit. We will not receive any of the proceeds of their sales of common stock.

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Our common stock

          As of July 1, 2005, there were approximately 28,430,000 shares of our common stock outstanding. Our stock is traded in the over-the-counter market and quoted on the NASB bulletin board under the symbol "MNRD.OB." See "Market for Our Capital Stock."

Plan of distribution

          We expect that the selling securityholders will sell the shares primarily through sales into the over-the-counter market made from time to time at prices that they consider appropriate. See "Plan of Distribution."

Background of the offering

          We have sold significant amounts of our common stock, convertible preferred stock, common stock purchase warrants, and convertible promissory notes, in order to fund our operations and the development of our products, manufacturing capacity, and marketing capabilities. These securities have been sold in private offerings to investors in which one of the terms of the offering was our agreement to register the sale of the common stock by the investors, including sales of common stock to be issued to investors on conversion of the convertible preferred stock, common stock to be issued to the investors under warrants to purchase common stock, common stock to be issued to investors upon conversion of convertible promissory notes, and common stock to be issued to placement agents upon exercise of warrants issued to them or their designees in connection with the offerings.

          In the most recent private offering, we sold 11,260 shares of Series A convertible preferred stock (that are convertible into 500 shares of common stock each) and warrants to purchase 2,815,000 shares of common stock at $3.85 per share. At the initial closing on June 10, 2005, investors purchased a total of 7,035 shares of Series A preferred and warrants to purchase 1,758,750 shares of common stock, at a second closing on June 21, 2005, investors purchased 3,000 shares of Series A preferred together with warrants to purchase an additional 750,000 shares of common stock, and at a third closing on July 1, 2005, investors purchased a total of 1,225 shares of Series A preferred together with warrants to purchase an additional 306,250 shares of common stock.

          This registration includes the shares of common stock issuable under the Series A convertible preferred and upon exercise of the related warrants under registration rights granted to the investors in connection with our most recent private offering, and it also includes shares issued or issuable in connection with previous private placements under registration rights granted to the purchasers in those offerings. This registration covers:

  •   
8,619,000 shares of common stock that are or may become issuable to holders of Series A convertible preferred and 3,659,500 shares of common stock that may be issued upon exercise of related warrants to purchase common stock that are exercisable at $3.85 per share;
  •   
8,057,726 shares of common stock resulting from shares originally sold by Minrad Inc. under a series of private placements and then exchanged for our shares under the terms of the merger of Minrad Inc. our subsidiary on December 16, 2004;

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  •   
1,000,000 shares of common stock issued by us on May 20, 2004 as part of 1,800,000 shares of common stock paid to retire an outstanding promissory note for $75,000;
  •   
906,960 shares of common stock sold by us at $1.75 per share in private placements between July 15, 2004 and February 7, 2005;
  •   
1,903,570 shares of common stock that are or may become issuable to holders upon conversion of $2.5 million of outstanding convertible promissory notes and upon exercise of 375,000 shares of common stock issuable upon exercise of related warrants at $1.75 per share held by investors or their transferees; and
  •   
973,805 shares of common stock issuable upon exercise of warrants at prices ranging from $1.25 to $2.00 that we issued to placement agents (or their designees) who assisted us and Minrad Inc. in making private placements of securities.

 

RISK FACTORS

        An investment in our common stock is speculative and involves a high degree of risk. You should carefully consider the following risks in connection with any investment in our common stock. The risks and uncertainties described below are not the only ones facing our company. Additional risks and uncertainties may also adversely impair our business operations. If the damages threatened by any of the following risks actually occur, our business, financial condition or results of operations would likely suffer significantly. In any of those cases, the value of our common stock could decline significantly, and you may lose all of part of your investment.

          We are subject to a number of risks, including those enumerated below. Any or all of these risks could have a material adverse effect on our business, financial condition, results of operations, and cash flows and on the market price of our common stock.

Risks Related to Our Business

We are currently in a growth stage and may experience setbacks in both business and product development.

          We currently manufacture and market generic inhalation anesthetics and recently launched SabreSourceTM, our second generation real-time image guidance system. We also are developing a drug/drug delivery system for conscious sedation. We are subject to all of the risks inherent in both the creation of a new business and the development of new and existing products, including the absence of a history of significant operations. Our operations, especially in our real-time image guidance line of business, have been limited, and, as a result, we must establish many functions that are necessary to conduct business. These areas include managerial and administrative structure, sales and marketing activities, financial systems and personnel recruitment.

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We have historically experienced operating losses and expect to continue to experience losses in the future.

          Our operating subsidiary has not been profitable since its inception in 1994. As of March 31, 2005, after giving effect to the merger, we had an accumulated deficit of approximately $25 million. We may continue to incur additional losses in the future as a result of a high level of operating expenses, significant up-front expenditures in the production and marketing activities and very limited revenue from the sale of our products.

          We currently sell the generic inhalation anesthetics, isoflurane and enflurane, and recently launched our SabreSourceTM real-time image guidance system and related products. We may never realize significant revenues, or be profitable, from the sale of our products. Each of the following factors, among others, may influence the timing and extent of our profitability, if any:

    regulatory approval or clearance of our products;
    market acceptance of our products and innovations;
    our ability to effectively manufacture our products; and
    our ability to efficiently market and distribute our products to customers.

We will need to raise additional capital to fulfill our business strategies. We may also incur unforeseen costs. Failure to attract additional capital or obtain a line of credit would adversely affect our business.

          We currently operate at a loss and intend to increase our operating expenses significantly due to the ongoing growth of our anesthetics and analgesics business and the expansion of our sales and marketing functions in connection with the recent launch of SaberSourceTM and the related line of Light SabreTM products. In addition, our future capital needs will be substantial. We are planning to expand our Bethlehem facility to provide the capacity to produce in a timely manner the quantities of isoflurane, enflurane, sevoflurane and desflurane that we may be required to deliver to our international sales partners in the future under existing contracts in order to allow us to remain the exclusive provider of these inhalation anesthetics to those sales partners in their respective sales regions and to avoid damages under those contracts. We also expect to incur substantial costs related to the research and development of our conscious sedation program. The long sales cycle in our real-time image guidance product line from initial customer contact to actual revenue generation, if any, also may place a significant burden on our liquidity position. Finally, unforeseen costs could require us to seek additional capital.

          We do not currently have any permanent arrangements or credit facilities in place as a source of funds. We are currently negotiating to obtain a $5 million line of credit.  We also expect to seek to raise additional funds in the future through private or public sales of equity securities or the incurrence of additional indebtedness. Additional funding may not be available on favorable terms, or at all. Any additional equity financing may result in significant dilution to our company's existing stockholders. If we fail to obtain sufficient additional capital in the future, we could be forced to curtail our growth strategy by reducing or delaying capital expenditures and acquisitions, selling assets or downsizing or restructuring our operations.

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The loss of the services of key personnel would adversely affect our business.

          Our future success depends to a significant degree on the skills, experience and efforts of our executive officers and senior management staff. The loss of the services of existing personnel, particularly William Burns and, prior to the completion of the conscious sedation program, John McNeirney, would be detrimental to our research and development programs and to our overall business.

We must hire and retain skilled technical and managerial personnel.

          Qualified personnel are in great demand among acute care companies. Our success depends in large part on our ability to attract, train and retain qualified management and highly-skilled employees, particularly technical, sales and marketing personnel and assembly technicians. Any failure to attract and retain the highly-trained technical personnel that are integral to direct sales, technology development and technical support teams may limit the rate at which we can generate sales and develop new products or product enhancements. Similarly, the failure to recruit key scientific and managerial personnel in a timely manner would be detrimental to our research and development programs and to our overall business. If we are unable to attract and retain skilled persons or we lose skilled technical personnel, our business, results of operations and financial condition would be adversely affected.

We may be unable to execute our business strategy.

          Our business strategy in the real-time image guidance line relies heavily upon the sale of our Light SabreTM products, a family of patented disposable products that is used with our SabreSourceTM system. While some of our Light SabreTM products have been accepted by the FDA, at this time we have fully developed only a portion of the tooling necessary to manufacture these products. Bringing these products to market involves the design and fabrication of sophisticated tooling for plastic injection molding. Since tooling manufacture is inherently expensive, the designs must be considered carefully to avoid costly mistakes. Unforeseen difficulties in the development of these products, as well as other medical device products, may lead to significant delays in the production of tooling and the subsequent generation of revenue.

          Market acceptance of our real-time image guidance products depends in part on our ability to demonstrate that our products are cost-effective and easier to use, and that they offer technological advantages. Additionally, we may experience design, manufacturing, marketing or other difficulties that could delay or prevent our development, introduction or marketing of new versions of our products. As a result of these types of difficulties and delays, our development expenses may increase and, as a consequence, our business, results of operations and financial condition could suffer.

          Our strategy in our anesthesia and analgesia line of business relies heavily on our ability to expand our product offerings in the anesthesia market, most notably through the launch of sevoflurane. All of our planned product offerings require some form of regulatory acceptance in both the domestic and international markets. Unforeseen difficulties in the development, regulatory acceptance, production, or distribution of these products may lead to significant delays in the generation of revenue.

          The development of our conscious sedation system is dependent upon our ability to recruit and retain competent technical staff to complete the project and the further development, prototyping and testing of the device that would administer the drug component of the system in conformance with FDA

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requirements.  Additionally, unforeseen delays in regulatory acceptance/approval could adversely affect the market introduction of the system.

We depend on strategic partnerships and relationships.

          Our success depends largely upon our ability to create and maintain important relationships with commercial partners, particularly in international distribution. We currently rely on 30 international sales partners to market our anesthesia and analgesia products, and we intend to co-market our real-time image guidance products with therapy partners. If we are unable to maintain strategic partnerships currently in place and develop additional strategic partnerships in critical areas, such as international sales, our business, results of operations and financial condition may be adversely affected.

We face competition in our industry, and many of our competitors have substantially greater experience and resources.

          We compete with other companies within the image guidance market, many of which have more capital, more extensive research and development capabilities and greater marketing and human resources than we do. Some of these image guidance competitors include Medtronic, Inc., BrainLAB, Inc., Stryker Corporation, and Biopsys Medical, a division of Johnson & Johnson. We believe we are the only company with a real-time image guidance system with an accuracy of plus or minus 1 mm at a distance of 1 meter. In the image guidance arena, however, radiation exposure from fluoroscopy and the need for accuracy in interventional procedures are well-recognized concerns. As a result, there is no guarantee that present fluoroscope manufacturers, radiological suppliers, biopsy vendors and suppliers of minimally-invasive medical devices are not already engaged in research and product development to address these concerns or will not become engaged in these areas of research and product development. We expect competition to increase as technological advances are made and commercial applications broaden. Our competitors may develop new or enhanced products or processes that may be more effective, less expensive, safer or more readily available than any products or processes developed by us, and we may not be able to compete successfully.

          Similarly, in the anesthesia and analgesia product line, our company directly competes with larger and more established companies, such as Abbott Laboratories and Baxter International, Inc., that have more capital, more extensive research and development capabilities and greater marketing and human resources than we do. Competitors may develop new or enhanced products or processes that may be more effective, less expensive, safer or more readily available than any products or processes that we develop. Our products or processes may not compete successfully, and research and development by others may render our products or processes obsolete or uneconomical.

We rely upon third-party manufacturers and suppliers, which puts us at risk for supplier business interruptions.

          We believe that success in our real-time image guidance line of business depends in part on our ability to retain third parties to sub-assemble our products in accordance with established quality and cost standards in sufficient quantities and in a timely manner. Third-party manufacturers may not perform as we expect. If third-party manufacturers fail to perform, our ability to market products and to generate revenue would be adversely affected.

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          We manufacture our product line of inhalation anesthetics at our Bethlehem facility. We rely on the continuing availability of certain specialty raw materials from a small number of suppliers. Our policy is to qualify three suppliers for each specialty raw material where possible. See "Raw Materials," below. In some instances, if we were unable to acquire these materials when needed our production capacity would be adversely affected.

We may face future product liability claims that may result from the use of our products.

          We are subject to potential product liability claims relating to our real-time image guidance and anesthesia and analgesia line of products. We currently maintain product liability insurance with coverage limits of $3,000,000 in the aggregate annually. This coverage and any coverage obtained in the future may be inadequate to protect us in the event of a successful product liability claim, and we may not be able to increase the amount of such insurance coverage or even renew it. Our insurance does not cover, and we are not aware of any suitable insurance that would cover, product liability claims for any of our products undergoing clinical trials. A successful product liability claim could have a material adverse effect on our business, results of operations and financial condition. In addition, substantial, complex or extended litigation could cause us to incur large expenditures and divert the attention of management and other significant resources. We also do not carry insurance to cover the costs of recalling any of our products. If we need to recall a product, we may incur substantial costs and product liability claims.

Business interruptions beyond our control have occurred in the past and may take place in the future, forcing a decrease in production and diminished operational capabilities.

          In February 2003, storm damage forced a significant business interruption at our Bethlehem facility. We filed a multi-million dollar claim for damages in connection with the interruption with our insurance carrier, The Chubb Group of Insurance Companies. To date, we have received a progress payment of $500,000. There can be no assurance that we will receive additional funds from Chubb or the timing of the receipt of such funds, if any.

We face significant risks associated with our international operations, which could have a material adverse effect on our business, results of operations and financial condition.

          We market our products in select markets outside of the United States. We generated 56% of our revenue for the three-month period ended December 31, 2004, and 94% of our revenue for the three-months ended March 31, 2005, from international sales. We expect that our revenues in select international markets will continue to account for a significant portion of our revenues. Our international operations are subject to a number of risks. Recently, restrictions of the Venezuelan government on the repatriation of United States dollars from Venezuela adversely affected our sales of inhalation anesthetics in Venezuela. While we have taken measures to mitigate the impact of these restrictions on our business, there can be no assurance that restrictions of the Venezuelan and other governments will not adversely affect our business, financial condition or results of operations in the future. Also, customers in the Middle East have recently shown reluctance to purchase products from U.S. companies as a result of negative sentiments toward the U.S. government following the commencement of the war in Iraq. These and the following risks associated with our international operations, among others, may materially adversely affect our business, financial condition or results of operations:

    difficulties in enforcing and collecting accounts receivable under some countries' legal systems;

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    local regulations may restrict our ability to sell our products or conduct other operations;
    political instability could disrupt our operations;
    longer payment cycles in some markets, with resulting adverse effects on our cash flow;
    the imposition of additional trade barriers, tariffs, taxes or restrict the import of our products; and
    fluctuations in exchange rates of the United States dollar could adversely affect our results of operations.

Significant additional governmental regulation could subject us to unanticipated delays, which would adversely affect our revenues.

          Our business strategy depends in part on our ability to get our products into the market as quickly as possible. Additional laws and regulations, or changes to existing laws and regulations, that are applicable to our business may be enacted or promulgated and the interpretation, application or enforcement of existing laws and regulations may change. We cannot predict the nature of any future laws, regulations, interpretations, applications or enforcements, or the specific effects any of these might have on our business. Any future laws, regulations, interpretations, applications, or enforcements could delay or prevent regulatory approval or clearance of our products and our ability to market our products. Moreover, if we do not comply with existing or future laws or regulations we could be subject to the following types of enforcement actions by the FDA and other agencies:

    fines;
    injunctions;
    civil penalties;
    recalls or seizures of our products;
    total or partial suspension of the production of our products;
    withdrawal of existing approvals or premarket clearances of our products;
    refusal to approve or clear new applications or notices relating to our products;
    recommendations by the FDA that we not be allowed to enter into government contracts; and
    criminal prosecution.

Failure to obtain regulatory approval for our products in the future may adversely affect our business.

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          Under the provisions of the U.S. Food, Drug and Cosmetic Act, we must obtain clearance from the FDA prior to commercial use in the United States of some of the products that we may develop.

          Medical Devices. The production and marketing of our real-time image guidance products and our ongoing research and development activities relating thereto are subject to regulation by numerous governmental authorities in the United States and other countries. Additionally, sales of medical devices outside the United States are subject to foreign regulatory requirements that vary widely from country to country. The time required to obtain approval for sale in each respective country may be longer or shorter than that required for FDA approval in the United States. To sell our products inside European Union member countries and an increasing number of other countries, we will be required to obtain EN13485 certification. We expect that we will obtain the certification for our Buffalo facility in July 2005; however we can give you no assurance that we will obtain the certification when planned, or at all.

          Pharmaceutical Products. The production and marketing of our pharmaceutical products, including our conscious sedation system, are also subject to significant regulation by the FDA in the United States and by numerous governmental authorities under the laws of other countries. Although we have satisfied these regulatory requirements for our current products in the United States and in the other countries in which we currently market our products, we will need to satisfy all governmental regulations before we can introduce any new pharmaceutical products in the United States or extend the sale of our existing inhalation anesthetics to additional foreign countries. The time required to obtain any of these additional regulatory approvals is uncertain and we may not be able to obtain them in a timely manner, or at all.

          Manufacturing Guidelines. Regulations regarding the manufacture and sale of our products are subject to change. We cannot predict what impact, if any, such changes may have on our business, financial condition or results of operation. Failure to comply with applicable regulatory requirements could have material adverse effect on our business, financial condition and results of operations.

          Additionally, the time required for obtaining regulatory approval is uncertain. We may encounter delays or product rejections based upon changes in FDA policies, including cGMP standards, during periods of product development. We may encounter similar delays in countries outside of the United States. We may not be able to obtain these regulatory acceptances on a timely basis, or at all.

          The failure to obtain timely regulatory acceptance of our products, any product marketing limitations, or any product withdrawal would have a material adverse effect on our business, financial condition and results of operations. In addition, before it grants approvals, the FDA or any foreign regulatory authority may impose numerous other requirements with which we must comply. Regulatory acceptance, if granted, may include significant limitations on the indicated uses for which the product may be marketed. FDA enforcement policy strictly prohibits the marketing of accepted products for unapproved uses. Product acceptance could be withdrawn, or civil or criminal sanctions could be imposed, for our failure to comply with regulatory standards or the occurrence of unforeseen problems following initial marketing.

          The third party manufacturers and suppliers that we depend on to manufacture our products are required to adhere to FDA regulations regarding cGMP standards and similar regulations in other countries, which include testing, control and documentation requirements. Ongoing compliance with cGMP regulations and other regulatory requirements is monitored by periodic inspection by the FDA and

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comparable agencies in other countries. If we fail to comply with regulatory requirements, including marketing or promoting products for unapproved uses, we could be subject, among other things, to the enforcement actions discussed above under the risk factor entitled "Significant additional governmental regulation could subject us to unanticipated delays, which would adversely affect our revenues."

          Changes in existing regulations or adoption of new governmental regulations or policies could prevent or delay regulatory acceptance of our products. Some material changes to medical devices are also subject to FDA review and acceptance. Delays in receipt of, or failure to obtain, acceptances, or the loss of previously obtained acceptances, or failure to comply with existing or future regulatory requirements could have a material adverse effect on our business, financial condition and results of operations.

We are subject to environmental regulations, and any failure to comply may result in substantial fines and sanctions.

          Our operations are subject to United States and international environmental laws and regulations governing, among other things, emissions to air, discharges to waters and the generation, handling, storage, transportation, treatment and disposal of raw materials, waste and other materials. We believe that we are and have been operating our businesses and facilities in a manner that complies in all material respects with environmental, health and safety laws and regulations. Many of these laws and regulations provide for substantial fines and criminal sanctions for violations. Generally, the operation of an inhalant pharmaceutical manufacturing plant and the handling of specialty raw materials entail risks of failure to comply with many regulatory requirements, and we may incur material costs or liabilities if we fail to maintain our operations in full compliance.

          We may have to make significant expenditures in the future to comply with evolving environmental, health and safety requirements, including new requirements that may be adopted or imposed in the future. To meet changing licensing and regulatory standards, we may have to make significant additional site or operational modifications that could involve substantial expenditures or reduction or suspension of certain operations. We cannot be certain that we have identified all environmental and health and safety matters affecting our activities and in the future our environmental, health and safety problems and the costs to remediate them, may be materially greater than we expect.

Future acquisitions may divert management and may involve risk of undisclosed liabilities.

          We may from time to time pursue acquisitions that we believe complement our existing operations. Growth by acquisition involves risks that could adversely affect our business, including the diversion of management time from operations to pursue and complete acquisitions, and difficulties in integrating additional operations and personnel of acquired companies. In addition, any future acquisitions could result in significant costs, the incurrence of additional indebtedness or issuance of equity securities to fund the acquisition, and contingent or undisclosed liabilities, all of which could materially adversely affect our business, financial condition and results of operations.

          In connection with any future acquisition, we generally will seek to minimize the impact of contingent and undisclosed liabilities by obtaining indemnities and warranties from the seller that may be supported by deferring payment of a portion of the purchase price. However, these indemnities and warranties, if obtained, may not fully cover the liabilities due to their limited scope, amount of duration, the financial limitations of the indemnitor or warrantor, or other reasons.

-11-

We became public by means of a reverse merger, and as a result we are subject to the risks associated with the prior activities of the public company. In addition, we may not be able to attract the attention of major brokerage firms or institutional buyers.

          Additional risks may exist because we became public through a "reverse merger" with a shell corporation that did not have significant recent operations or assets, but which has had operations in the past. Although we performed a due diligence review of the public company, there can be no assurance that we will not be exposed to undisclosed liabilities resulting from the prior operations of our company.

          Security analysts of major brokerage firms and securities institutions may not cover us since there are no broker-dealers who sold our stock in a public offering who would have an incentive to follow or recommend the purchase of our common stock. No assurance can be given that established brokerage firms will want to conduct any financings for us in the future.

We have recently been in default under obligations with various service providers, vendors and lenders.

          Due to cash flow constraints, in the recent past we were in significant arrears to some of our service providers and other vendors, and we were unable to pay all of our financial obligations as they became due. As a result of these defaults, creditors asserted claims against us from time to time. Although we have obtained forbearances or made other arrangements with our creditors, the risk of claims by creditors could continue until we are able to generate positive cash flow on a consistent basis. Any default under our obligations could have a material adverse effect on our business, results of operations and financial condition.

We incur significant costs as a result of being a public company.

          As a public company, we are subject to significant legal, accounting and other expenses to which Minrad Inc. was not subject prior to the reverse merger. We incur costs associated with our public company reporting requirements under the Securities and Exchange Act of 1934, costs associated with recently adopted corporate governance standards and internal control requirements, including standards and requirements under the Sarbanes-Oxley Act of 2002, as well as new rules implemented by the SEC. These rules and regulations increase our legal and financial compliance costs and make some activities more time-consuming and costly. These new rules and regulations also make it more difficult and more expensive for us to obtain director and officer liability insurance. We may be required to accept reduced policy limits and coverage or incur substantially higher costs to obtain the same or similar coverage. As a result, it may be more difficult for us to attract and retain qualified individuals to serve on our board of directors or as executive officers. We are currently evaluating and monitoring developments with respect to these new rules and we cannot predict or estimate the amount of additional costs we may incur or the timing of such costs.

Investor confidence and the price of our common stock may be adversely impacted if we are unable to comply with Section 404 of the Sarbanes-Oxley Act of 2002.

          As an SEC registrant, we are subject to the rules adopted by the SEC pursuant to Section 404 of the Sarbanes-Oxley Act of 2002, which require us to include in our annual report on Form 10-KSB our management's report on, and assessment of the effectiveness of, our internal control over financial

-12-

reporting. In addition, our independent registered public accounting firm must attest to and report on management's assessment of the effectiveness of our internal control over financial reporting. These requirements will first apply to our annual report for the fiscal year ending December 31, 2006. If we fail to achieve and maintain adequate internal control over financial reporting, there is a risk that we will not comply with all of the requirements imposed by Section 404. Moreover, effective internal control over financial reporting, particularly that related to revenue recognition, is necessary for us to produce reliable financial reports and is important in helping to prevent financial fraud. Any of these possible outcomes could result in an adverse reaction in the financial marketplace due to a loss of investor confidence in the reliability of our financial statements, which ultimately could harm our business and could negatively impact the market price of our common stock.

 

Risks Related to Our Intellectual Property

If we are not able to adequately protect our intellectual property, we may not be able to compete effectively.

          Our success depends, to a significant degree, upon the protection of our proprietary technologies. While we currently own 13 U.S. patents and numerous foreign counterparts that protect our products, we will need to pursue additional protections for our intellectual property as we develop new products and enhance existing products. We may not be able to obtain appropriate protections for our intellectual property in a timely manner, or at all.

          The filing and maintenance fees and the legal and other expenses necessary for us to obtain and maintain appropriate patent protection in the United States and important foreign countries are significant. If we do not have sufficient funds, we may not be able to maintain appropriate protections. In addition, if we are forced to resort to legal proceedings to enforce our intellectual property rights, the proceedings could be burdensome and expensive. In addition, our proprietary rights could be at risk if we are unsuccessful in, or cannot afford to pursue, those proceedings. We also rely on trade secrets and contract law to protect some of our proprietary technology. We have entered into confidentiality and invention agreements with our employees and consultants. Nevertheless, these agreements may not be honored and they may not effectively protect our right to our unpatented trade secrets and know-how. Moreover, others may independently develop substantially equivalent proprietary information and techniques or otherwise gain access to our trade secrets and know-how.

          In 1995, the U.S. Patent and Trademark Office adopted changes to the U.S. patent law that made the term of issued patents 20 years from the date of filing rather than 17 years from the date of issuance, subject to specified transition periods. Beginning in June 1995, the patent term became 20 years from the earliest effective filing date of the underlying patent application. These changes may reduce the effective term of protection for patents that are pending for more than three years. In addition, as of January 1996, all inventors who work outside of the United States are able to establish a date of invention on the same basis as those working in the United States. This change could adversely affect our ability to prevail in a priority of invention dispute with a third party located or doing work outside of the United States. While we cannot predict the effect that these changes will have on our business, they could have a material adverse effect on our ability to protect our proprietary information. Furthermore, the possibility of extensive delays in the patent issuance process could effectively reduce the term during which a marketed product is protected by patents.

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          We may need to obtain licenses to patents or other proprietary rights from third parties. We may not be able to obtain the licenses required under any patents or proprietary rights, or they may not be available on acceptable terms. If we do not obtain required licenses, we may encounter delays in product development or find that the development, manufacture or sale of products requiring licenses could be foreclosed. We may, from time to time, support and collaborate in research conducted by universities and governmental research organizations. We may not be able to acquire exclusive rights to the inventions or technical information derived from these collaborations, and disputes may arise over rights in derivative or related research programs conducted by us or our collaborators.

If we infringe on the rights of third parties, we may not be able to sell our products, and we may have to defend against litigation and pay damages.

          If a competitor were to assert that our products infringe on its patent or other intellectual property rights, we could incur substantial litigation costs and be forced to pay substantial damages. Third-party infringement claims, regardless of their outcome, would not only consume significant financial resources, but would also divert our management's time and attention. Such claims could also cause our customers or potential customers to purchase competitors' products or defer or limit their purchase or use of our affected products until resolution of the claim. If any of our products are found to violate third-party intellectual property rights, we may have to re-engineer one or more of our products, or we may have to obtain licenses from third parties to continue offering our products without substantial re-engineering. Our efforts to re-engineer or obtain licenses could require significant expenditures and may not be successful.

If our trademarks and trade names are not adequately protected, we may not be able to build brand loyalty and our sales and revenues may suffer.

          Our registered or unregistered trademarks or trade names may be challenged, cancelled, infringed, circumvented or declared generic or determined to be infringing on other marks. We may not be able to protect our rights to these trademarks and trade names, which we need to build brand loyalty. Over the long term, if we are unable to establish a brand based on our trademarks and trade names, then we may not be able to compete effectively and our sales and revenues may suffer.

 

Risks Related to Our Securities

We have a concentration of stock ownership and control.

          Our common stock ownership is highly concentrated. See Item 12 of this report, "Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters." As a result, a relatively small number of stockholders, acting together, will be able to control all matters requiring stockholder approval, including the election of directors and approval of mergers and other significant corporate transactions. This concentration of ownership may have the effect of delaying, preventing or deterring a change in control of our company. It could also deprive our stockholders of an opportunity to receive a premium for their shares as part of a sale of our company and it may affect the market price of our common stock.

Our stock price may be volatile because of factors beyond our control and you may lose all or a part of your investment.

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          Any of the following factors could affect the market price of our common stock:

    our failure to achieve and maintain profitability;
    our failure to meet financial analysts' performance expectations;
    our exposure to product liability claims resulting from the use of our products;
    changes in earnings estimates and recommendations by financial analysts;
    actual or anticipated variations in our quarterly results of operations;
    changes in market valuations of similar companies;
    announcements by us or our competitors of significant contracts, new products, acquisitions, commercial relationships, joint ventures or capital commitments;
    the loss of major customers or product or component suppliers;
    the loss of significant partnering relationships;
    product liability lawsuits or product recalls; and
    general market, political and economic conditions.

          In the past, following periods of volatility in the market price of a company's securities, securities class action litigation has often been instituted. A securities class action suit against us could result in substantial costs and divert our management's time and attention, which would otherwise be used to benefit our business.

We may experience future sales of large amounts of common stock by existing shareholders.

          Future sales of large amounts of our common stock by existing stockholders pursuant to Rule 144 under the Securities Act of 1933 or otherwise could adversely affect the market price of our common stock. Certain of our affiliates, who beneficially own large amounts of our common stock, are not subject to lockup letters or other forms of restriction on the sale of their shares. Sales of a large number of shares of common stock in the public market could adversely affect the market price and could materially impair our future ability to generate funds through sales of common stock or other equity securities.

We are subject to penny stock regulations and restrictions.

          Our common stock is approved for quotation on the OTC Bulletin Board. Since our common stock trades below $5.00 per share, it is considered a "penny stock" and is subject to SEC rules and regulations that impose limitations on the manner in which it can be publicly traded.

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          These regulations require the delivery, prior to any transaction involving a penny stock, of a disclosure schedule explaining the penny stock market and the associated risks. Potential investors in our common stock are urged to obtain and read this disclosure carefully before purchasing any shares that are deemed to be "penny stock." Also under these regulations, certain brokers who recommend a penny stock to persons other than established customers or certain accredited investors must make a special written suitability determination regarding the purchaser and receive the purchaser's written agreement to a transaction prior to sale. These procedures require the broker-dealer to:

     
    obtain from the investor information concerning his or her financial situation, investment experience and investment objectives;
    reasonably determine, based on that information, that transactions in penny stocks are suitable for the investor and that the investor has sufficient knowledge and experience as to be reasonably capable of evaluating the risks of penny stock transactions;
    provide the investor with a written statement setting forth the basis on which the broker-dealer made their determination of suitability; and
    receive a signed and dated copy of the statement from the investor, confirming that it accurately reflects the investor's financial situation, investment experience and investment objectives.

          These regulations have the effect of limiting the trading activity of our common stock and reducing the liquidity of an investment in our common stock.

          Stockholders should be aware that, according to SEC Release No. 34-29093, the market for penny stocks has suffered in recent years from patterns of fraud and abuse.

          Our "penny stock" designation may adversely affect the development or continuation of the public market for our common stock.

We have not paid and have no plans to pay cash dividends.

          Since our inception, we have not paid any cash dividends on our common stock and we do not anticipate paying any cash dividends in the foreseeable future.

 

FORWARD LOOKING STATEMENTS

        Some of the statements contained in this prospectus are not statements of historical or current fact. As such, they are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. We have based these forward-looking statements on our current expectations, which are subject to known and unknown risks, uncertainties and assumptions. They include statements relating to:

 
  •  

future sales and financings;

-16-

 
  •  
the future development of our business;
 
  •  
our ability to execute our business strategy;
 
  •  
projected expenditures; and
 
  •  
trends in government regulation.

        You can identify forward-looking statements by terminology such as "may," "will," "should," "could," "expects," "intends," "plans," "anticipates," "believes," "estimates," "predicts," "potential" or "continue" or the negative of these terms or other comparable terminology. These statements are not predictions. Actual events or results may differ materially from those suggested by these forward-looking statements. In evaluating these statements and our prospects generally, you should carefully consider the factors set forth below. All forward-looking statements attributable to us or persons acting on our behalf are expressly qualified in their entirety by these cautionary factors and to others contained throughout this prospectus. We are under no duty to update any of the forward-looking statements after the date of this prospectus or to conform these statements to actual results.

        Although it is not possible to create a comprehensive list of all factors that may cause actual results to differ from the results expressed or implied by our forward-looking statements or that may affect our future results, some of these factors are set forth under "Risk Factors" in this prospectus and in our periodic filings made with the SEC.

WHERE YOU CAN FIND ADDITIONAL INFORMATION

          We file reports, proxy statements and other information with the Securities and Exchange Commission, or SEC. We have also filed a registration statement on Form SB-2 (Commission File No. 333- _______), including exhibits, with the SEC with respect to the stock offered by this prospectus. This prospectus is part of the registration statement, but does not contain all of the information included in the registration statement or exhibits. You may read and copy the registration statement and these reports, proxy statements and other information at the SEC's Public Reference Room at 450 Fifth Street N.W., Washington, D.C. 20549. Please call the SEC at 1-800-SEC-0330 for further information on the Public Reference Room. The SEC maintains an internet site at http://www.sec.gov that contains reports, proxy and information statements and other information regarding issuers that file electronically with the SEC, including our company.

          This prospectus does not contain all of the information set forth in the registration statement and the exhibits and schedules thereto. For further information with respect to us and the shares of stock offered under this prospectus, reference is made to the registration statement, including the exhibits and schedules thereto. Statements contained in this prospectus as to the contents of any contract or other document are not necessarily complete and, where any such contract or document is an exhibit to the registration statement, each statement with respect to the contract or document is qualified in all respects by the provisions of the relevant exhibit, which is hereby incorporated by reference.

          We make available free of charge on or through our internet website our annual report on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K and amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 as soon as

-17-

reasonably practicable after we electronically file this material with, or furnish it to, the SEC. Our Internet address is http://www.minrad.com. The information contained on Minrad's website is not incorporated by reference in this prospectus and should not be considered a part of the prospectus.

 

USE OF PROCEEDS

          Each of the selling securityholders will receive all of the net proceeds from the sale of shares by that shareholder. We will not receive any of the net proceeds from the sale of the shares. The selling securityholders will pay any underwriting discounts and commissions and expenses incurred by the selling securityholders for brokerage, accounting, tax or legal services or any other expenses incurred by the selling securityholders in offering or selling their shares. We will bear all other costs, fees and expenses incurred in effecting the registration of the shares covered by this prospectus, including, without limitation, all registration and filing fees, NASDAQ listing fees, blue sky registration and filing fees, and fees and expenses of our counsel and accountants.

          A portion of the shares covered by this prospectus are, prior to their sale under this prospectus, issuable upon conversion of convertible promissory notes or convertible preferred stock, or issuable upon exercise of common stock purchase warrants. Upon conversion of the promissory notes, we will be relieved of the debt obligations for the notes at the rate of $1.75 per share issued. Upon the exercise of warrants by payments of cash, we will receive the exercise price of the warrants, which range from $1.25 to $3.85 per share. To the extent that we receive cash upon the exercise of the warrants, we expect to use that cash for general corporate purposes.

DILUTION

          We are not selling any of the shares of common stock in this offering. All of the shares sold in this offering will be held by the selling securityholders at the time of the sale, so that no dilution will result from the sale of the shares.

SELLING SECURITYHOLDERS

Selling Securityholders who hold Series A preferred stock and related warrants

          We are registering this offering under the terms of registration rights agreements between us and the holders of our Series A preferred stock and related warrants. The shares of Series A preferred stock and warrants were originally issued by us in transactions exempt from the registration requirements of the 1933 Act to persons reasonably believed to be "accredited investors" as defined in Regulation D under the 1933 Act. For additional information regarding the shares of Series A preferred stock and warrants see "Summary -- Background of the Offering" above. We are registering the shares of common stock underlying the Series A preferred stock and the warrants in order to permit the selling securityholders who purchased those securities to offer the shares of common stock for resale from time to time.

          In accordance with the terms of registration rights agreements with the holders of shares of Series A preferred stock and related warrants, this prospectus generally covers the resale of 130% of the maximum number of shares of common stock issuable upon dividends paid in stock on the Series A preferred stock, upon conversion of the shares of Series A preferred stock, and upon exercise of the warrants (in each case without taking into account any limitations on the conversion of the shares of

-18-

Series A preferred stock and exercise of the warrants set forth in the Certificate of Designations, Preferences and Rights of Series A Preferred Stock and in the related warrants) as of the trading day immediately preceding the date this registration statement was initially filed with the SEC. Because the conversion price of the Series A preferred stock and the exercise price of the related warrants may be adjusted, the number of shares that will actually be issued to the holders of those securities may be more or less than the number of shares being offered by this prospectus.

          Under the terms of the Series A preferred stock and the warrants, a selling securityholder may not convert the Series A preferred stock or exercise the related warrants, to the extent such conversion or exercise would cause such selling securityholder, together with its affiliates, to beneficially own a number of shares of common stock which would exceed 9.99% of our then outstanding shares of common stock following such conversion or exercise, excluding for purposes of such determination shares of common stock issuable upon conversion of the shares of Series A preferred stock which have not be converted and exercise of the warrants which have not been exercised. The numbers in the second column do not reflect this limitation. The selling securityholders may sell all, some or none of their shares in this offering. See "Plan of Distribution."

Selling Securityholders other than those who hold Series A preferred stock and related warrants

          We are registering the resale of common stock issued or issuable to selling securityholders other than the holders of Series A preferred stock and related warrants under the terms of registration rights agreements with such other holders that require us to effect "piggy-back registration" of the sale of their shares when we file a registration statement. For additional information about securities held by persons other than holders of Series A preferred stock and related warrants see "Summary -- Background of the Offering" above. The group of other selling securityholders includes the following persons.

          Former holders of common stock of Minrad Inc. Included in the common stock being registered for sale are 8,057,726 shares of common stock that were issued to certain of the selling stockholders in exchange for shares of Minrad Inc. when that company merged with our wholly owned subsidiary on December 16, 2004. The shares of Minrad Inc. that were converted were originally issued by Minrad Inc. in transactions exempt from the registration requirements of the 1933 Act under section 4(2) of the Act to persons reasonably believed to be "accredited investors" as defined in Regulation D under the 1933 Act.

          Holders of common stock originally issued by us. Included in the common stock being registered are (a) 906,960 shares of common stock sold by us at $1.75 per share in private placements between July 15, 2004 and February 7, 2005, and (b) 1,000,000 shares that are part of 1,800,000 shares issued by us in May of 2004 in exchange for an outstanding $75,000 note. The shares issued by us in exchange for the note include: 500,000 shares issued to the Tobin Family Trust; 250,000 shares issued to Laird Cagan; and 250,000 shares issued to Eric McAfee. The common shares sold by us in private placements and issued by us in satisfaction of the note were issued in transactions exempt from the registration requirements of the 1933 Act under Section 4(2) of the Act to persons reasonably believed to be "accredited investors" as defined in Regulation D under the 1933 Act.

          Holders of common stock issuable upon conversion convertible promissory notes and upon exercise of related warrants. Included in the common stock being registered are 1,528,570 shares of common stock that may become issuable upon conversion of principal and interest on a $1,500,000 convertible promissory note and related warrants to purchase 225,000 shares at $1.75 per share held by the Tobin Family Trust and a $1,000,000 convertible promissory note and warrants to purchase 150,000

-19-

shares of common stock at $1.75 per share held by Laird Cagan. The conversion price of the convertible notes is $1.75 per share (subject to adjustment). The convertible promissory notes and related warrants were issued in transactions exempt from the registration requirements of the 1933 Act under Section 4(2) of the Act to persons reasonably believed to be "accredited investors" as defined in Regulation D under the 1933 Act.

          Holders of warrants to purchase common stock. Included in the common stock being registered for resale are shares issuable upon exercise of warrants to purchase 320,108 shares of common stock at $1.75 per share, 90,697 shares at $1.75 per share, and 563,000 shares at $2.00 per share. All of these warrants were issued to placement agents, including Chadbourn Securities, Inc. and related parties, in connection with private placements of securities made by us or by Minrad Inc. The issue of these warrants was made in transactions exempt from the registration requirements of the 1933 Act under Section 4(2) of the Act to persons reasonably believed to be "accredited investors" as defined in Regulation D under the 1933 Act.

Selling Securityholder Table

          The table below lists the selling securityholders and other information regarding the beneficial ownership of the shares of common stock by each of the selling securityholders. The second column lists the number of shares of common stock beneficially owned by each selling stockholder as of June 30, 2005, assuming conversion of all Series A preferred stock, conversion of all convertible notes, and exercise of all of the warrants held by the selling securityholders on that date, without regard to any limitations on conversion or exercise. The third column lists the shares of common stock being offered pursuant to this prospectus by each of the selling securityholders. The fourth column lists the number of shares that will be beneficially owned by the selling securityholders assuming all of the shares offered pursuant to this prospectus are sold and that shares beneficially owned by them, as of June 30, 2005, but not offered hereby are not sold.

          The inclusion of any securities in the following table does not constitute an admission of beneficial ownership by the persons named below. Except as indicated in the footnotes to the table, no selling securityholder has had any material relationship with us or our predecessors or affiliates during the last three years.

Name of Selling Shareholder

Number of
Shares of
Common Stock
Beneficially
Owned Prior To
Offering (1)

Number of
Shares of
Common Stock
Being Offered(1)

Shares of
Common Stock
Owned After the
Offering (2)

Percentage
Rubicon Master Fund  

4,361,812

 

4,361,812

(3)

0

  --
Crestview Capital, LLC  

2,255,906

 

2,255,906

(4)

0

  --
Enable Growth Partners LP  

403,468

 

403,468

(5)

0

  --
Enable Opportunities Partners, LP  

70,879

 

70,879

(6)

0

  --
Spencer Trask Illumination Fund, LLC  

272,613

 

272,613

(7)

0

  --
International Capital Advisory, Inc.   1,058,413  

358,413

(8) 700,000   2.5%
Laird Cagan   2,884,360  

2,011,376

(9) 872,984   2.1%
Eric A. McAfee   969,625  

432,106

(10) 537,519   1.9%
Toibb Investment, LLC  

2,828,394

 

2,828,394

(11)

0

  --
                 
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HLTGT, LLC  

327,136

 

327,136

(12)

0

  --
                 
Howard Smuckler  

27,261

 

27,261

(13)

0

  --
Michael Toibb  

54,523

 

54,523

(14)

0

  --
Gail Toibb Carrier  

54,523

 

54,523

(15)

0

  --
Scott M. & Cheryl L. Hergott Living
     Trust 2003
 

54,523

 

54,523

(16)

0

  --
                 
SDS Capital Group SPC, Ltd.  

272,613

 

272,613

(17) 0   --
CAMOFI Capital Master LDC  

381,659

 

381,659

(18) 0   --
H.T. Wainwright & Company Inc.   15,000   15,000 (19) 0   --
Corsair Capital Partners, L.P.   463,442   463,442 (20) 0   --
Corsair Capital Investors, Ltd.   63,246   63,246 (21) 0   --
Corsair Capital Partners 100, L.P.   18,538   18,538 (22) 0   --
Biscayne Capital   12,500   12,500 (23) 0   --
                 
Veronica Au Yeung Mui Lai  

267,189

 

267,189

 

0

  --
Ramin Azar  

10,000

 

10,000

(24)

0

  --
Sterling Trust Co FBO Y Barker 75191  

14,285

 

14,285

 

0

  --
Steven Barnes  

30,000

 

30,000

 

0

  --
Mark E. Bernhard  

20,000

 

20,000

 

0

  --
Salim and Maria Bhamla JT TEN  

20,000

 

20,000

 

0

  --
           

0

   
Capital Group Int. LLP  

40,000

 

40,000

 

0

  --
Commercial Utility Consultants  

11,482

 

11,482

 

0

  --
Michael Brown Trust dated 6/30/2000  

200,000

 

200,000

 

0

  --
William H. Burns, Jr.  

1,858,001

 

3,334

(25)

1,854,667

  6.4%
Cagan Capital-Private Equity Fund
     II, LLC
 

9,000

 

9,000

(26)

0

  --
Michael Chiang  

80,000

 

80,000

 

0

  --
Joseph B. Childrey  

20,000

 

20,000

 

0

  --
Brad Chisick  

50,000

 

50,000

 

0

  --
Kathleen Cole  

5,000

 

5,000

(27)

0

  --
Carter Compton  

20,000

 

20,000

 

0

  --
           

0

   
Fairmount Analytics  

40,000

 

40,000

(28)

0

  --
Linden Growth Partners  

828,193

 

828,193

 

0

  --
Kenneth Cushman & Carol
     Cushman JT TEN
 

28,000

 

28,000

 

0

  --
Peter Delbove  

20,000

 

20,000

 

0

  --
Lincoln Associates, LLC  

294,195

 

294,195

 

0

  --
Fred Dulock  

56,000

 

56,000

 

0

  --
Brad & Susan Dunlap  

20,000

 

20,000

 

0

  --
Brad Dunlap  

9,000

 

9,000

(29)

0

  --
                 
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Bret Dunlap  

280,000

 

280,000

 

0

  --
Donald Farley  

298,739

 

146,667

(30)

152,072

  --
           

0

   
Barry & Kira Fay  

85,602

 

85,602

 

0

  --
Lori Filoon  

14,285

 

14,285

 

0

  --
Hillcrest Investors Ltd.  

20,000

 

20,000

 

0

  --
Barbara Hall  

2,000

 

2,000

(31)

0

  --
Rick Hutcheon  

50,000

 

50,000

 

0

  --
William Todd Issac  

595,087

 

595,087

 

0

  --
Gita V. Iyer  

40,000

 

40,000

 

0

  --
Ross J. Jicomelli  

51,429

 

51,429

 

0

  --
Edmund Wylie Johnson & Margaret
     Johnson JT TEN
 

150,000

 

150,000

 

0

  --
Roger Kaiser  

10,000

 

10,000

 

0

  --
                 
Kirk Kamsler  

100,306

 

1,556

(32)

98,750

  *
Bill Kemp  

44,000

 

44,000

 

0

  --
James Kogut  

1,667

 

1,667

 

0

  --
Krannenburg Fund, LP  

204,000

 

204,000

 

0

  --
George Kubala  

28,571

 

28,571

 

0

  --
Thomas Lechner  

20,000

 

20,000

 

0

  --
Steve Lee  

30,000

 

30,000

(33)

0

  --
Joshua Levinson  

616

 

616

 

0

  --
Robert Lifeso  

637,881

 

29,151

(34)

608,730

  2.1%
John Lorence  

20,000

 

20,000

 

0

  --
           

0

  --
Leon Lui  

15,553

 

889

 

14,664

  *
Benedict P. Maguire  

20,000

 

20,000

 

0

  --
Edgemont Group  

30,000

 

30,000

 

0

  --
John C. McNeirney  

175,246

 

889

(35)

174,359

  *
Robert Malnychuk  

7,400

 

7,400

 

0

  --
Barbra Miller  

8,571

 

8,571

 

0

  --
George Myers  

40,000

 

40,000

 

0

  --
Daniel R. Pahl  

5,714

 

5,714

 

0

  --
Myro Louis Panas  

62,286

 

62,286

 

0

  --
Petersoin Family Trust 8/16/00  

285,715

 

285,715

 

0

  --
           

0

   
Gary Pleiger  

10,000

 

10,000

 

0

  --
Jim Phillips  

15,000

 

15,000

 

0

  --
Patricia Prass  

2,000

 

2,000

(36)

0

  --
Chadbourn Securities, Inc.  

20,507

 

20,507

(37)

0

  --
Derek Raghavan  

5,000

 

5,000

 

0

  --
Dr. Kumar Ramalingham & Mala
     Ramalingham
 

60,000

 

60,000

 

0

  --
Ursula Ridgeway  

14,286

 

14,286

 

0

  --
George Roberts  

40,000

 

40,000

 

0

  --
                 
-22-

 

Elizabeth Rose  

109,349

 

109,349

 

0

   
New England Partners Capital, LP  

3,980,392

 

3,505,392

(38)

475,000

  1.7%
           

0

   
Darren Saltzberg  

3,125

 

3,125

 

0

  --
Timothy Shaffer  

30,000

 

30,000

 

0

  --
Don Sharp & Brad Sharp JT TEN  

20,000

 

20,000

 

0

  --
David Shoob  

9,118

 

9,118

 

0

  --
Philip J. Smith  

15,000

 

15,000

 

0

  --
John A. Sobrato 1979 Trust  

160,000

 

160,000

 

0

  --
Ted Stanley  

10,000

 

10,000

 

0

  --
Ricky D. Thompson  

20,000

 

20,000

 

0

  --
Tobin Family Trust  

2,169,795

 

1,824,795

(39)

345,000

  1.2%
Viswanathan Family trust 3/18/00  

14,286

 

14,286

 

0

  --
           

0

   
Billy J. Vitek  

20,000

 

20,000

 

0

  --
Susan Vitek  

15,000

 

15,000

 

0

  --
John E. Wenaas  

30,000

 

30,000

 

0

  --
Mark Whitman  

6,000

 

6,000

 

0

  --
J& AM Wolfenbarger  

20,000

 

20,000

 

0

  --
David Wright  

20,000

 

20,000

 

0

  --
                 

_____________________________________________

*Less than 1%.

(1)    The shares indicated include shares that may be issued in the future as result of dividend provisions of the Series A preferred, and as a result of anti-dilution and adjustment provisions of the Series A preferred and certain of the warrants held by the Selling Securityholders.
(2)    Assumes that all of the shares offered hereby are sold and that shares owned before the offering but not offered hereby are not sold.
(3)    Shares held by Rubicon Master Fund include: (i) 3,061,812 shares underlying Series A Preferred and (ii) 1,300,000 shares underlying Warrants exercisable at $3.85 per share.
(4)    Shares held by Crestview Capital LLC include: (i) 1,530,906 shares underlying Series A Preferred and (ii) 725, 000 shares underlying warrants exercisable at prices ranging from $2.00 to $3.85 per share.
(5)    Shares held by Enable Growth Partners LP include: (i) 283,218 shares underlying Series A Preferred and (ii) 120,250 shares underlying warrants exercisable at $3.85 per share.
   
 

-23-

 

(6)    Shares held by Enable Opportunities Partners LP include: (i) 49,754 shares underlying Series A Preferred and (ii) 21,125 shares underlying warrants exercisable at $3.85 per share.
(7)    Shares held by Spencer Trask Illumination Fund LLC include: (i) 191,363 shares underlying Series A Preferred and (ii) 81,250 shares underlying warrants exercisable at $3.85 per share.
(8)    Shares held by International Capital Advisory, Inc. include: (i) 107,163 shares underlying Series A Preferred and (ii) 251,250 shares underlying warrants exercisable at prices ranging from $1.25 to $3.85 per share. See "Certain Relationships and Related Party Transactions -- Financing Arrangements with Cagan McAfee Capital Partners, LLC and related parties."
(9)    Shares held by Laird Cagan include: (i) 786,357 shares of outstanding Common Stock, (ii) 128,596 shares underlying Series A Preferred, (iii) 484,995 shares underlying warrants exercisable at prices ranging from $1.25 to $3.85 per share, and (iv) 611,428 shares of common stock underlying convertible promissory notes. See "Certain Relationships and Related Party Transactions -- Financing Arrangements with Cagan McAfee Capital Partners, LLC and related parties."
(10)    Shares held by Eric A. McAfee include: (i) 250,000 shares of outstanding Common Stock, (ii) 127,831 shares underlying Series A Preferred and (iii) 54,275 shares underlying warrants exercisable at $3.85 per share. See "Certain Relationships and Related Party Transactions -- Financing Arrangements with Cagan McAfee Capital Partners, LLC and related parties."
(11)   Shares held by Toibb Investment LLC include: (i) 1,932,769 shares underlying Series A Preferred and (ii) 895,625 shares underlying warrants exercisable at prices ranging from $2.00 to $3.85 per share.  Harris Toibb has sole voting and investment power with respect to these securities.  See note (12) below.
(12)   Shares held by HLTGT LLC include: (i) 229,636 shares underlying Series A Preferred and (ii) 97,500 shares underlying warrants exercisable at $3.85 per share.  Harris Toibb has sole voting and investment power with respect to these securities.  See note (11) above.
(13)    Shares held by Howard Smuckler include: (i) 19,136 shares underlying Series A Preferred and (ii) 8,125 shares underlying warrants exercisable at $3.85 per share.
(14)    Shares held by Michael Toibb include: (i) 38,273 shares underlying Series A Preferred and (ii) 16,250 shares underlying warrants exercisable at $3.85 per share.
(15)    Shares held by Gail Toibb Carrier include: (i) 38,273 shares underlying Series A Preferred and (ii) 16,250 shares underlying warrants exercisable at $3.85 per share.
(16)    Shares held by Scott M. & Cheryl L. Hergott Living Trust 2003 include: (i) 38,273 shares underlying Series A Preferred and (ii) 16,250 shares underlying warrants exercisable at $3.85 per share.
(17)    Shares held by SDS Capital Group SPC, Ltd. include (i) 191,363 shares underlying Series A Preferred and (ii) 81,250 shares underlying warrants exercisable at $3.85 per share.
(18)    Shares held by CAMOFI Capital Master LDC include (i) 267,709 shares underlying Series A Preferred and (ii) 113,750 shares underlying warrants exercisable at $3.85 per share.
   
 

-24-

 

(19) Shares held by H.T. Wainwright & Company Inc. include 15,000 shares underlying warrants exercisable at $2.00 per share.
(20) Shares held by Corsair Capital Partners, L.P. include (i) 325,317 shares underlying Series A Preferred and (ii) 138,125 shares underlying warrants exercisable at $3.85 per share.
(21) Shares held by Corsair Capital Investors, Ltd. include (i) 44,396 shares underlying Series A Preferred and (ii) 18,850 shares underlying warrants exercisable at $3.85 per share.
(22) Shares held by Corsair Capital Partners 100, L.P. include (i) 13,013 shares underlying Series A Preferred and (ii) 5,525 shares underlying warrants exercisable at $3.85 per share.
(23) Shares held by Biscayne Capital include 12,500 shares underlying warrants exercisable at $2.00 per share.
(24) Shares held by Ramin Azar include 10,000 shares underlying warrants exercisable at $1.25 per share.
(25)  William Burns is our President and CEO. See "Directors and Executive Officers" and "Certain Relationships and Related Party Transactions -- Obligations payable to BioSight Inc. and BioVision Inc."
(26)   Shares held by Cagan Capital-Private Equity Fund II, LLC include 9,000 shares underlying warrants exercisable at $1.25 per share.   Laird Cagan is the Managing Director of Cagan Capital Private Equity Fund II, LLC. Mr. Cagan has no ownership interest in the fund. See "Certain Relationships and Related Party Transactions -- Financing Arrangements with Cagan McAfee Capital Partners, LLC and related parties."
(27) Shares held by Kathleen Cole include 5,000 shares underlying warrants exercisable at $1.25 per share.
(28) Shares held by Fairmount Analytics include 40,000 shares underlying warrants exercisable at $1.25 per share.
(29) Shares held by Brad Dunlap include 9,000 shares underlying warrants exercisable at $1.25 per share.
(30)    Donald Farley is one of our directors. See "Directors and Executive Officers" and "Certain Relationships and Related Party Transactions -- Financing Arrangements with Spencer Trask Specialty Group, LLC.
(31) Shares held by Barbara Hall include 2,000 shares underlying warrants exercisable at $1.25 per share.
(32)    Kirk Kamsler is our Senior Vice President of Commercial Development. See "Directors and Executive Officers."
   
 

-25-

 

(33) Shares held by Steve Lee include 30,000 shares underlying warrants exercisable at $1.25 per share.
(34)    Robert Lifeso is one of our directors. See "Directors and Executive Officers."
(35)  John McNeirney is one of our Senior Vice Presidents and our Chief Technology Officer. See "Directors and Executive Officers."
(36) Shares held by Patricia Prass include 2,000 shares underlying warrants exercisable at $1.25 per share.
(37) Shares held by Chadbourn Securities, Inc. include 20,507 shares underlying warrants exercisable at prices ranging from $1.25 to $2.00 per share.  See "Certain Relationships and Related Party Transactions -- Financing Arrangements with Cagan McAfee Capital Partners, LLC and related parties."
(38)  See "Certain Relationships and Related Party Transactions -- Financing Arrangements with New England Capital Partners, LLC."
(39)  Shares held by Tobin Family Trust include: (i) 500,000 shares of outstanding common stock, (ii) 407,653 shares underlying warrants exercisable at prices ranging from $1.25 to $1.75 per share, and (iii) 917,142 shares underlying convertible promissory notes. See "Certain Relationships and Related Party Transactions -- Financing Arrangements with Cagan McAfee Capital Partners, LLC and related parties."

PLAN OF DISTRIBUTION

          We are registering shares of common stock to permit the resale of such common stock by the holders from time to time after the date of this prospectus. We will not receive any of the proceeds from the sale by the selling securityholders of the securities. We will bear all fees and expenses incident to our obligation to register the shares of common stock.

          The selling securityholders may sell all or a portion of the securities beneficially owned by them and offered hereby from time to time directly or through one or more underwriters, broker-dealers or agents. If the securities are sold through underwriters or broker-dealers, the selling securityholders will be responsible for underwriting discounts or commissions or agent's commissions. The securities may be sold in one or more transactions at fixed prices, at prevailing market prices at the time of the sale, at varying prices determined at the time of sale, or at negotiated prices. These sales may be effected in transactions, which may involve crosses or block transactions,

  
  •   
on any national securities exchange or quotation service on which the securities may be listed or quoted at the time of sale;
 
  
  •  
in the over-the-counter market;
  
  •   
in transactions otherwise than on these exchanges or systems or in the over-the-counter market;

-26-

 

  
  •   
through the writing of options, whether such options are listed on an options exchange or otherwise;
  
  •   
ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;
  
  •   
block trades in which the broker-dealer will attempt to sell the securities as agent but may position and resell a portion of the block as principal to facilitate the transaction;
 
  
  •   
purchases by a broker-dealer as principal and resale by the broker-dealer for its account;
  
  •   
an exchange distribution in accordance with the rules of the applicable exchange;
  
  •   
privately negotiated transactions;
  
  •   
short sales;
  
  •  
pursuant to Rule 144 under the Securities Act;
  
  •   
broker-dealers may agree with the selling securityholders to sell a specified number of such securities at a stipulated price per security;
 
  
  •   
a combination of any such methods of sale; and
  
  •   
any other method permitted pursuant to applicable law.

          If the selling securityholders effect such transactions by selling the warrants, or shares of common stock to or through underwriters, broker-dealers or agents, such underwriters, broker-dealers or agents may receive commissions in the form of discounts, concessions or commissions from the selling securityholders or commissions from purchasers of the warrants or shares of common stock for whom they may act as agent or to whom they may sell as principal (which discounts, concessions or commissions as to particular underwriters, broker-dealers or agents may be in excess of those customary in the types of transactions involved). In connection with sales of any securities or otherwise, the selling securityholders may enter into hedging transactions with broker-dealers, which may in turn engage in short sales of the securities in the course of hedging in positions they assume. The selling securityholders may also sell securities short and deliver securities covered by this prospectus to close out short positions. The selling securityholders may also loan or pledge securities to broker-dealers that in turn may sell such securities.

          The selling securityholders may pledge or grant a security interest in some or all of the warrants or shares of common stock owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell shares of common stock from time to time pursuant to this prospectus or any amendment to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act of 1933, as amended, amending, if necessary, the list of selling securityholders to include the pledgee, transferee or other successors in interest as selling securityholders under this prospectus. The selling securityholders also may transfer and donate the warrants or shares of common stock in other circumstances in which case the transferees, donees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus.

-27-

          The selling securityholders and any broker-dealer participating in the distribution of the shares of common stock may be deemed to be "underwriters" within the meaning of the 1933 Act, and any commission paid, or any discounts or concessions allowed to, any such broker-dealer may be deemed to be underwriting commissions or discounts under the 1933 Act. At the time a particular offering of the securities is made, a prospectus supplement, if required, will be distributed which will set forth the aggregate amount of securities being offered and the terms of the offering, including the name or names of any broker-dealers or agents, any discounts, commissions and other terms constituting compensation from the selling securityholders and any discounts, commissions or concessions allowed or reallowed or paid to broker-dealers.

          Under the securities laws of some states, the securities may be sold in such states only through registered or licensed brokers or dealers. In addition, in some states the warrants and shares of common stock may not be sold unless such warrants or shares of common stock have been registered or qualified for sale in such state or an exemption from registration or qualification is available and is complied with.

          The selling securityholders may choose not to sell any or may choose to sell less than all of the shares of common stock registered pursuant to the shelf registration statement, of which this prospectus forms a part.

          The selling securityholders and any other person participating in such distribution will be subject to applicable provisions of the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder, including, without limitation, Regulation M of the 1934 Act, which may limit the timing of purchases and sales of any of the shares of common stock by the selling securityholders and any other participating person. Regulation M may also restrict the ability of any person engaged in the distribution of the shares of common stock to engage in market-making activities with respect to the shares of common stock. All of the foregoing may affect the marketability of the shares of common stock and the ability of any person or entity to engage in market-making activities with respect to the shares of common stock.

          We will pay all expenses of the registration of the shares of common stock pursuant to the registration rights agreement, estimated to be $54,000 in total, including, without limitation, Securities and Exchange Commission filing fees and expenses of compliance with state securities or "blue sky" laws; provided, however, that a selling securityholder will pay all underwriting discounts and selling commissions, if any. We will indemnify the selling securityholders against liabilities, including some liabilities under the 1933 Act, in accordance with the registration rights agreements, or the selling securityholders will be entitled to contribution. We may be indemnified by the selling securityholders against civil liabilities, including liabilities under the 1933 Act, that may arise from any written information furnished to us by the selling securityholder specifically for use in this prospectus, in accordance with the related registration rights agreements, or we may be entitled to contribution.

          Once sold under the shelf registration statement, of which this prospectus forms a part, the shares of common stock will be freely tradable in the hands of persons other than our affiliates.

 

BUSINESS

-28-

General Business Overview

          On December 16, 2004, Minrad International, Inc., formerly known as Technology Acquisition Corporation, acquired Minrad Inc., a Delaware corporation, through a reverse merger of a wholly owned subsidiary into Minrad Inc. As a result, Minrad Inc. became a wholly owned subsidiary of Minrad International, and the stockholders of Minrad Inc. became the beneficial owners of approximately 83% of Minrad International's then-outstanding common stock. In this prospectus, unless otherwise indicated or the context otherwise requires, "we," "us," and "our" refer to Minrad International, Inc. and its subsidiary.

          Through Minrad Inc., we operate an acute care business with two product lines: (1) real-time image guidance and (2) anesthesia and analgesia. We currently sell patented real-time image guidance technologies that enable medical professionals to improve the accuracy of interventional procedures and reduce the exposure to radiation. We recently launched SabreSourceTM, a second-generation real-time image guidance system. Our real-time image guidance products have broad applications in orthopedics, neurosurgery, interventional radiology and anesthesia. We manufacture and market generic inhalation anesthetics for use in connection with human and veterinary surgical interventions. We are also developing a drug/drug delivery system for conscious sedation, which, similar to nitrous oxide used in dental surgery, provides a patient with pain relief without loss of consciousness.

          Minrad International, Inc. was incorporated in the State of Nevada in 1996 under the name Roatan Medical Technologies, Inc. While Minrad International engaged in various businesses over the years, it had no operations immediately prior to its acquisition of Minrad Inc. On April 25, 2005, Minrad International reincorporated from Nevada to Delaware.  Minrad Inc. was incorporated in Delaware in 1994.

          In 1998, we introduced our initial product, the Dual Radiation Targeting System, or DRTS®. Today, our real-time image guidance product is SabreSourceTM. SabreSourceTM uses unique x-ray and laser technology to enable medical professionals to precisely visualize both the surface point of entry and true angle of approach required to reach an internal treatment area or biopsy site. We also manufacture a line of hand held surgical instruments called Light SabreTM. These products use the inherent accuracy of the SabreSourceTM laser to enable a medical professional to accurately position the handheld instrument at the point of incision and then to accurately guide the instrument to the targeted internal treatment or biopsy site.

          We entered into the anesthesia and analgesia business in December 2000 through our $1.4 million acquisition of the inhalation anesthetic business of Celltech-Medeva. The Bethlehem, Pennsylvania manufacturing facility that we acquired in the acquisition is FDA registered and cGMP compliant. This facility has the capacity to manufacture, package and distribute isoflurane, enflurane, sevoflurane and other halogenated ethers.

          We currently sell isoflurane and enflurane, two of the four modern halogenated inhalation anesthetics in use in the world today. We also have existing contracts under which we plan to sell sevoflurane by the end of 2005 and desflurane as early as 2007 in select international markets.

          We currently are developing a drug delivery system for the use of halogenated ethers as inhalation analgesics. This initiative seeks to leverage our two core competencies: precision medical devices and inhalation anesthetics. We have filed patent application 10/272,794, "Drug Delivery for Conscious Sedation" (Burns, McNeirney and Terrell), for a new system for administering conscious

-29-

sedation that would compete with the widespread use of nitrous oxide, sedative hypnotics and narcotic analgesics in both the pre-hospital and critical care hospital markets. We believe that sevoflurane is a halogenated ether that may be used effectively in conscious sedation systems.

Real Time Image Guidance

Overview

          We are a developer of enabling technology for minimally invasive surgical procedures. We believe several factors currently drive the market for surgical systems and their related products, including:

    aging of the population;
    development of minimally invasive surgical procedures;
    focus on increased productivity and lower costs;
    transition from hospital-based to outpatients procedures; and
    demand for improved therapeutic outcomes.

          We believe that approximately 15% of all surgical procedures currently use fluoroscopy, CT-scans or other forms of imaging. Additionally, we estimate that the number of minimally-invasive spine procedures are growing at an annual overall rate of 40% and pain management is growing at an annual rate of about 20%. The corresponding increased use of fluoroscopy, CT scans and other forms of imaging increases the risk of radiation exposure.

          We believe that the use of our real-time image guidance products can minimize healthcare costs and improve patient outcomes by:

    decreasing operating time;
    enabling additional procedures to be performed on a minimally invasive basis;
    minimizing patient trauma and recovery time;
    improving surgical accuracy; and
    reducing radiation exposure in fluoroscopically-guided procedures.

SabreSourceTM, our second generation image guidance system, which we recently launched, uses patented x-ray and laser technology to enable medical professionals to visualize both the surface point of entry and the true angle of approach required to precisely target an internal treatment area or biopsy site. SabreSourceTM, like our first-generation product, DRTS®, significantly reduces radiation exposure to patients and operating room personnel. In addition, the SabreSourceTM system significantly improves

-30-

"ease of use," provides a much larger targeting area and gives the medical professional improved control and visibility over target acquisition.

          We also manufacture a line of handheld surgical instruments. Light SabreTM uses the inherent accuracy of the SabreSourceTM laser to enable a medical professional to precisely position the hand-held instrument at the point of incision and to accurately guide the instrument to the targeted internal treatment or biopsy site. Presently, our Light SabreTM line includes six disposable products, including syringes, aspirating needles, spinal needles, bone and core tissue biopsy needles and a catheter introducer.

Our Real-Time Image Guidance Products

          We are developing real-time image guidance systems that have broad applications in orthopedics, neurosurgery, interventional radiology and anesthesia. Our first-generation image guidance system, DRTS®, enables medical professionals to improve the accuracy of interventional procedures and reduce significantly the exposure of patients and medical professionals to radiation. DRTS® technology uses a laser beam to target a single point with FDA-accepted accuracy of plus or minus 1mm at a distance of 1 meter. Physicians using DRTS® cited several features of the system:

 

    a reduction in radiation of 50 - 90% depending on the type of procedure;
    the elimination of multiple instrument penetrations in attempts to locate subsurface target and corresponding reduction in time, expense and trauma; and
    improved surgical accuracy and corresponding reduction in complications.

          In a study entitled, "Accuracy of Fluoroscopically Assisted Laser Targeting of the Cadaveric Spine to Place Transpedicular Screws", Journal of Spinal Disorders 2000:13; 412-418 by R.M. Schwend et al., our DRTS® platform was used by surgical residents for pedicle screw implantation into 184 pedicles. Although none of these residents had previously performed the procedure, the residents had an average error rate of 1.6%, with all errors deemed "non-critical."

          R. Hugate et al. from Hershey Medical Center, Hershey, Pennsylvania presented a "mirror" study of Dr. Schwend's paper as a poster at the American Academy of Orthopedic Surgeons conference held in Dallas, Texas in February 2002. Routine fluoroscopic technique was compared to alternative sophisticated image guidance systems in the performance of the same pedicle screw procedure that was performed by residents in the study described in the previous paragraph. Experienced surgeons participated in this study. The results of the study showed that fluoroscopy alone had a critically malpositioned error rate of 15.3%. The alternative systems had higher critical error rates of 22.2% and 36.0% respectively. The results of this study compare to the non-critical 1.6% error rate for the DRTS® platform reported in Dr. Schwend's study discussed above.

          Another peer-reviewed scientific study, "Vertebroplasty: techniques to avoid complications," was written by D.B. Moreland, M.D., Michael K. Landi, M.D. and Walter Grand, M.D., and published in The Spine Journal (2001) 66-71. He stated in his summary that significant complications can occur in vertebroplasty procedures and are likely underreported. In this study, Dr. Moreland described his technique of performing vertebroplasties and avoiding serious complications by using the DRTS®

-31-

system. Dr. Moreland is a shareholder in our company and is a member of our Scientific Advisory Board. Dr. Landi is a co-founder of and shareholder in our company, and is a member of our Scientific Advisory Board. Dr. Grand is a shareholder in our company.

          While we designed the DRTS® system to retrofit existing mobile C-Arm fluoroscopes, ultimately the size of the system and the need for repositioning when locating multiple targets led to only moderate adoption of the product.

          We now offer SabreSourceTM, our second-generation image guidance system, which uses patented X-ray and laser technology to enable medical professionals to visualize both the surface point of entry and the true angle of approach required to precisely target an internal area or biopsy site. Like DRTS®, SabreSourceTM significantly reduces radiation exposure to patients and operating room personnel, yet it is smaller, can acquire multiple targets without repositioning, incorporates a quick-release and alignment system, can be used in a wider range of surgical procedures and can reduce surgical time. As in the case of DRTS®, the FDA accepts our accuracy claim of plus or minus 1 mm at a distance of 1 meter.

          SabreSourceTM is designed to retrofit to existing mobile C-Arm fluoroscopes with a "glove fit" thereby adding greater stability. Based on new technology (patent allowed), the SabreSourceTM is aligned to the entire X-ray beam instead of a single ray, enabling the physician to successfully target multiple subcutaneous sites of interest using a hand-held remote control unit. Unlike the more costly navigation systems currently on the market that rely on archival data, the SabreSourceTM system uses "real-time" fluoroscopic images to accurately guide a physician while the X-ray beam is turned off.

          Three accessories are integral parts of the SabreSourceTM system: (1) the three-compartment Tri-KnewTM battery charger and 12-volt NiCad battery packs that power the device; (2) a patented sterile disposable drape that covers the SabreSourceTM and C-Arm fluoroscope so that the system can be placed in the sterile field, and (3) a sterile drape that is used to cover the SabreSourceTM remote control. The patented platform drape has an optically correct window and must be used with the SabreSource to ensure that the accuracy of the laser beam is not compromised.

          We estimate that the market for image guidance systems, such as SabreSourceTM, was approximately $1.7 billion in 2004 with an anticipated annual growth rate of 6%. Upon reaching a targeted scale of production, we believe that a sale of one SabreSourceTM per month should generally cover the sales expense of the sales representative who sells the product.

          With its additional features and benefits, we believe that our SabreSourceTM image guidance system addresses most of the issues that limited the success of our DRTS® system. We believe that the new features will make it easier for medical professionals to incorporate the SabreSourceTM system into their everyday procedures.

Light SabreTM

          We also manufacture a line of handheld surgical instruments. Light SabreTM uses the inherent accuracy of the SabreSourceTM laser to enable a medical professional to guide the handheld instrument from the point of incision to the targeted internal treatment or biopsy site. Presently, our Light SabreTM line includes six disposable products, including FDA accepted syringes, aspirating needles, spinal needles, bone and core tissue biopsy needles and a catheter inducer, which "light up" when properly

-32-

aligned to access a subcutaneous site, thereby giving the medical professional a visual verification when the subcutaneous site is properly targeted. In 1998, the FDA accepted an accuracy claim for Light SabreTM products of plus or minus 3 mm at a depth of 100 mm.

          We believe that the level of accuracy produced by Light SabreTM products is critical in minimally invasive procedures, including biopsies and other procedures in pain management, in applied oncology, spinal applications, trauma and urology. Light SabreTM products can also be used as minimally invasive, precisely targeted drug delivery systems.

          We plan to continue to develop and introduce additional Light SabreTM products over the remaining 13 years of the life of the Light SabreTM patent. Our six existing FDA-accepted Light SabreTM products focus on pain management and spinal procedures. We are currently prototyping designs for therapeutic applications with two medical device companies and we have had preliminary discussions with several other manufacturers of medical devices. Pending successful cadaver trials, we anticipate granting product-specific licenses for the technology.

          Our future plans include the exploration of partnerships with imaging manufacturers to incorporate SabreSourceTM technology into their equipment. We believe that other imaging manufacturers will find our technology to be attractive because we have received an FDA Master File acceptance of our Light SabreTM Collimator, the portion of our product that, when used in conjunction with the SabreSourceTM technology, puts the light in Light SabreTM.

          FDA Master file acceptance allows other manufacturers who incorporate our Light SaberTM technology into their equipment to use our FDA acceptance and our accuracy claims for our Light SabreTM products when used with their equipment in conjunction with our SabreSourceTM technology. Manufacturers who license our Light SabreTM Collimator technology will only need to provide the FDA with a 30-day notice of utilization, thus accelerating time to market of their new products.

Our Real-Time Image Guidance Strategy

          The principle elements of our business strategy are designed to create a recognized standard of care for our SabreSourceTM system and related Light SabreTM line of products. We plan to focus on the following:

    Create a recognized standard of care. We believe the high degree of accuracy, limited exposure to radiation and ease of use of our SabreSourceTM system positions it potentially to become the standard of care for fluoroscopically-guided, minimally invasive, acute care procedures.
    Develop the use of consumables.

-- Our initial marketing emphasis will be directed at anesthesiologists at pain management clinics because of the call point similarities with our anesthetics and analgesics business. Pain management clinics have a higher patient volume with shorter procedures and patient recovery time than hospitals. In a typical clinic, a physician will perform many procedures per day that involve fluoroscopic guidance. We believe the potential for Light SabreTM products will be higher in these clinics and the selling cycle from initial evaluation to actual purchase would generally involve fewer people and be

-33-

 more rapid.

-- We also expect to focus our marketing efforts on hospitals. Hospital purchasing departments like to minimize the number of similar products in their inventory. Light SabreTM products and commodity products with similar uses are priced competitively, and both may be used in procedures that do not use SabreSourceTM technology. Unlike the competing commodity products, however, Light SabreTM products also provide "light up"-targeted guidance when used with a SabreSourceTM system. We believe that hospitals may be motivated to use Light SabreTM products in place of commodity products in order to take advantage of the multiple uses of Light SabreTM products and in order to reduce the number of similar products in their inventories.

    Establish therapy partners. We believe that our Light SabreTM technology could enhance the competitive advantage of medical devices manufactured by other companies. The introduction of third party products that use Light SabreTM technology could spur sales of our SabreSourceTM systems, which could in turn spur sales of additional Light SabreTM products. We also believe that the interventional accuracy and reduced exposure to radiation that our SabreSourceTM technology provides could enhance the competitive advantage of imaging equipment manufactured by other companies. We believe that the development of third party imaging equipment that includes SabreSourceTM technology would promote sales of Light SabreTM products. To these ends, we intend to establish relationships with therapy partners to develop new Light SabreTM applications. We also may partner with equipment manufacturers to include our SabreSourceTM technology in third-party imaging equipment.

 

Anesthesia and Analgesia

Overview

          Four primary halegenated inhalation ethers are used in surgical procedures: isoflurane, enflurane, sevoflurane, and desflurane. We currently manufacture and sell isoflurane and enflurane, and we have existing contracts under which we expect to manufacture and sell sevoflurane by the end of 2005 and desflurane as early as 2007 into select international markets.

          Our retired Vice President of Research, Ross Terrell, Ph.D., is the inventor of the majority of inhalation anesthetics sold in the world today. Dr. Terrell originally synthesized and patented isoflurane, enflurane and desflurane. He also holds an expired patent on the six compounds in the isoflurane, and sevoflurane family. We have retained Dr. Terrell as a Research Fellow and a member of our Scientific Advisory Board.

          We estimate, based on IMS data and other publicly available filings of other companies, that the market for inhalation anesthetics was approximately $925 million in 2004, a 10% increase from the prior year. We believe that the market will continue to grow primarily as a result of an anticipated increase in general surgeries (1.8% in the United States and 3.5% internationally during 2003 according to the American Hospital Association), and the substitution of more expensive anesthetic agents for lower cost anesthetic agents, resulting in an increased cost per surgery.

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          We manufacture our pharmaceutical products in our Bethlehem facility. We purchased this facility from Celltech-Medeva in December 2000 for $1.4 million. According to public records, Celltech-Medeva purchased the facility six years earlier for approximately $54 million. Although the Bethlehem facility contains state-of-the-art equipment, it was operating substantially below capacity. We acquired the business for four reasons:

    The operating room ("OR") call point for anesthesia and analgesia products matched that of our real-time image guidance system. In addition, we anticipated that the same sales partner would sell both product lines in many international markets.

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    As a result of our management's prior business experience, we were intimately familiar with the Celltech-Medeva line of inhalation products. Our know-how in producing inhalation anesthetics combined with our substantial operations and turn-around experience and our international industry relationships, provided us with the opportunity to improve plant operations.
    We believed that the inhalation anesthetic business could provide a revenue and cash generation platform.
    We believed that halogenated ethers could be used in conscious sedation.

Over a four-year period, our management has:

    installed a new plant management team;
    increased production capacity by 120%, while reducing plant employment and without capital investment;
    added RxElite as a partner for the distribution of our inhalation anesthetic products in the United States;
    added over 20 key international customers including E. Merck and General Electric;
    resourced key raw materials at substantial cost reductions;
    developed procedures and programs under which we produce sevoflurane and expect, following regulatory approval, to produce desflurane; and
    applied for patents on a conscious sedation system which, if approved by the appropriate regulatory authorities, may provide a springboard for the eventual transformation of our anesthesia and analgesia business to principally a proprietary product business.

          Today, as a result of process improvements, successful programs to improve yield and reduced energy consumption per kilo, we have achieved a 65% average cost reduction at the plant from the time of acquisition in December 2000.

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          Inhalation anesthetics are sold as 99.9% pure compounds. There are no additives or excipients. They are naturally aseptic and go through a phase change from liquid to vapor in their delivery. As such, the principal FDA regulation issues from a cGMP perspective are in the packaging of pure, final product. This is markedly different from a capsule or parenteral operation.

Our Anesthesia and Analgesia Products

Currently, our primary products are isoflurane and enflurane.

          Isoflurane is sold throughout the world for use in a wide range of surgeries. It is of particular use in neurosurgery due to its minimal impact on intracranial pressure and can be used to induce hypotension and reduce bleeding. Isoflurane is also used in the veterinary market, where it is the standard of care for procedures involving companion animals. Management estimates that present annual worldwide sales of isoflurane in 2004 exceeded $150 million, including approximately $50 million of sales in the veterinary market. We sell isoflurane for human use under the TerrellTM brand name and for veterinary use under the AttaneTM brand name.

          Enflurane is a niche product with principal applications in labor and delivery and where myocardial depression and related myocardial oxygen consumption is beneficial, such as coronary by-pass. It is the only inhalation anesthetic agent approved for labor and delivery and, as a result, its sales volume is highest in countries with higher birth rates. Management estimates that the present annual worldwide market for enflurane in 2004 was approximately $12 million. We sell enflurane under the Compound 347TM brand name.

          We have made improvements to the Bethlehem facility and can now manufacture sevoflurane. Following the receipt of additional regulatory approvals, we expect to begin selling sevoflurane in select international markets in 2005, and in additional international markets each year between 2006 and 2008. We will begin selling in domestic markets following the receipt of appropriate regulatory approvals, which we expect to receive in late 2006. Sevoflurane is the largest selling inhalation agent in the world. It is the agent of choice for pediatric and outpatient procedures because of its induction and recovery properties. Management estimates that the annual market for sevoflurane in 2004 approached $600 million. Abbott markets sevoflurane in the United States, Europe and Latin America. Maruishi markets sevoflurane in Japan and has marketing rights in China. We have one process patent that has been issued on the manufacture of sevoflurane and four other patents pending.

MR Tested Laryngoscope Blades & Handles

          To complement our inhalant anesthetic offerings, we have introduced magnetic resonance ("MR") tested laryngoscope blades and handles. Many patients, particularly children, claustrophobic adults and patients in pain, cannot remain still in an MRI magnet for the required time. The MR-tested laryngoscope blades and handles allow an anesthetist to safely intubate a patient very near (within fifteen centimeters) a 1.5 Tesla MRI magnet without ferro-magnetic or radio frequency interference. We have two U.S. patents on these specialty products.

Anesthesia and Analgesia Competitive Strategy

          Our two primary competitors in the supply of anesthetic agents are Abbott Laboratories and Baxter International, Inc., both of which are multi-national pharmaceutical and medical device

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companies. We believe that Abbott and Baxter will face increased competition when sevoflurane and desflurane become generic.

          We have a five-part strategy to compete in key global marketplaces:

    partner with national pharmaceutical firms prominent in the business;

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    provide a full line of products;
    maintain our status as the low-cost producer by leveraging our Bethlehem manufacturing facility through high volume and capacity expansion;
    identify niches that allow segmentation and branding; and
    develop proprietary anesthesia and analgesia products for conscious sedation, while maintaining generic volume.

          Our marketing partners are often among the leading pharmaceutical manufacturing and distribution companies in their respective country or region. Partners include: E. Merck in Japan, Germany, France, the United Kingdom, and Scandinavia; L&W in China; Panion in Taiwan; RxElite in the United States; Laboratorios PiSA in Mexico and Central America; Richmond Labs in Argentina and Spain; and Novartis in the United Kingdom veterinary market. We also supply enflurane directly to Baxter, which it markets worldwide.

          Our international marketing strategy is to first identify and establish a distribution partner relationship in a country or region. Following the execution of an agreement with each partner, we then file a registration for the sale of these products in a country or region. The registration process on average takes 12 to 24 months. Upon receipt of regulatory approval for new products in a country or region, we can leverage our existing distribution partnerships to accelerate our speed to market. Upon registration, we begin to sell our products to our international partner under the existing contracts. Presently, we have 15 partnerships under which we have manufactured and delivered inhalation anesthetics. We have targeted countries or regions to enter as the patents expire. As a result, our initial focus has been on the Pacific Rim and Latin America.

          Under our exclusive distribution agreements, a sales partner will maintain the exclusive right to distribute specified inhalation anesthetics in its respective sales region so long as it purchases specified minimum annual quantities of inhalation anesthetics at prices specified in the agreement.

          As of June 30, 2005, we had 28 active distribution contracts with sales partners that require, after anticipated regulatory approvals are obtained in the respective countries, increasing minimum annual purchases for the contracts to remain exclusive. By 2009, the annual minimum purchases for the distributors to maintain exclusivity by product and territory under existing agreements will reach $92.9 million.

$ Millions

Annual Minimums

 

2005

2006

2007

2008

2009

North America

5.8

18.4

43.6

56.2

56.2

           
          -37-

 

Europe

0.8

2.5

8.7

11.6

15.2

Latin America

2.7

5.2

6.9

7.0

7.2

Pacific

1.4

7.6

13.9

14.1

14.3

Total

10.7

33.7

73.1

88.9

92.9

Totals for

 

Isoflurane/Enflurane:

9.5

12.0

12.9

13.1

13.1

          Approvals for foreign registrations of generic drugs generally require a 12-24 month review period, depending on the country. In most cases, local government guidance is available on the average time required for approval. In addition to drug registration time, regulators in certain markets provide a period of years of exclusivity for the original manufacturer, and patent protection -- either composition or process -- is available in certain other markets for one or more of the participants. The respective parties to the distribution agreements agreed to these annual minimums after assessing the situation in the respective markets. The annual minimums are best viewed as providing a trend on the uptake of our inhalation anesthetic business.

          Beyond these agreements, we are currently negotiating distribution contracts with four prospective partners. These agreements may or may not become finalized. In addition, we are actively seeking representation in several major markets including, but not limited to, Italy, Australia, significant portions of Eastern Europe, South Korea, the Middle East, and the Indian Sub-continent.

          Also under the exclusive distribution agreements, each sales partner has agreed to purchase inhalation anesthetics only from us for distribution in its respective region, provided that we timely deliver inhalation anesthetics in accordance with the terms of the applicable agreement.

          In July 2004, we signed a contract with RxElite, Inc., a United States distributor of inhalation respiratory products. Assuming RxElite meets volume milestones in the contract to remain an exclusive distributor in the United States, U.S. sales under the contract with RxElite would approach $55 million in calendar year 2008. RxElite began purchasing human inhalation anesthetics under this contract on September 30, 2004.

          We believe that there are significant barriers to entry into the business of producing and selling inhalation anesthetics. These drugs are essentially specialty chemicals that must be manufactured in dedicated facilities, using proprietary intellectual property and operated by a highly skilled management team and work force.

Conscious Sedation

          We have under development a drug/drug delivery system for the use of halogenated ethers as inhalation analgesics, which we call "conscious sedation." This initiative seeks to leverage our two product lines: real-time image guidance systems and inhalation anesthetics. We have filed a patent application, "Drug Delivery for Conscious Sedation" (Burns, McNeirney and Terrell), for a new system for administering conscious sedation that would compete with the widespread use of nitrous oxide, sedative hypnotics and narcotic analgesics in both the pre-hospital and critical care hospital markets.

          Nitrous oxide and sedative hypnotics have been used with varying degrees of success as analgesics for centuries. Nitrous oxide, however, can produce side effects in patient and medical

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personnel alike, and can be addictive. Sedative hypnotics remain in the system for an extended period of time, even when used in conjunction with a reversal agent. In addition, in a small number of patients the reversal agent is ineffective. Constant monitoring of these patients is required, and productivity and cost management can suffer as a result. Finally, sedative hypnotics are scheduled substances according to the U.S. Drug Enforcement Administration ("DEA"), and appropriate controls, safeguards and record-keeping are required.

          We believe that if administered safely, modern inhalation agents have the potential to be an attractive alternative to nitrous oxide and sedative hypnotics in conscious sedation. Modern inhalation agents meet the key requirements for conscious sedation as they are proven safe and effective at higher doses, reverse themselves through exhalation, have a very rapid uptake to analgesic levels and are not addictive or DEA-controlled substances. In the past, inhalation anesthetics were not used as analgesics due to the absence of equipment to accurately deliver the agents and the fact that the manufacturers of inhalation agents also made and sold anesthesia equipment costing $100,000-$200,000 per unit.

          We plan to produce a device that will "freeze" the delivered concentration at an analgesic level and not allow additional agent to be delivered. In October 2002, we filed an application for a U.S. Patent that covers the use of inhalation anesthetics as inhalation analgesics. On February 11, 2004, we received our preliminary report under the Patent Cooperation Treaty ("PCT"). All 43 claims on our patent were accepted.

          To preserve patient safety, the FDA does not allow the testing of both a new device and a new drug simultaneously. Pursuant to regulatory approvals, we plan to file a 510(k) application on the device in the fourth quarter of 2005 and subsequently file Investigational New Drug ("IND") applications for review by hospital and university Institutional Review Boards ("IRB") contingent on 510(k) acceptance. The predicate device on which our conscious sedation product is based is the electronically metered administration of nitrous oxide. Because the inhalation agents are already approved at a higher dose and have been safely administered, we plan to commence Phase III testing immediately following 510(k) acceptance and an IND filing on the agent. Presuming the agent was sevoflurane, this would allow our ANDA application for the manufacture and marketing of sevoflurane. We believe our conscious sedation product can be on the market to generate sales in a number of countries in 2007.

          We believe that the market for inhalation analgesics, including drugs and devices, could approximate $5 billion worldwide based on our market research estimates. Procedures that could benefit from this treatment include, but are not limited to, colonoscopy, burn dressing changes, pain relief pre-diagnosis in ambulance and emergency room, ICU/CCU sedation, dental and oral surgery procedures, relaxation for MRI diagnosis, office based dermatological or podiatric procedures, and certain catheterizations.

United States Regulatory Approvals for our Business

          The following table shows United States regulatory acceptances/approvals and patents related to our products.

Trade Name

510(k) no.

510(k) Acceptance

Date

Patent Number

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SabreSourceÔ Targeting System

K022935

10/11/2002

6,694,169
APP#60/516,039-pending
SabreSourceÔ Drape

K041846

8/26/2004

6,283,125
6,679,267
Light SabreÔ Aspiration Needle

K982018

8/7/1998

5,810,841
6,096,049
6,264,168
Light SabreÔ Bone Biopsy Needle

K982735

09/09/1998

5,810,841
6,096,049
6,264,168
Light SabreÔ Core Tissue Biopsy Needle

K981796

08/05/1998

5,810,841
6,096,049
6,264,168
Light SabreÔ Introducer Needle

K013040

12/07/2001

5,810,841
6,096,049
6,264,168
Light SabreÔ Spinal Needle

K021084

07/03/2002

5,810,841
6,096,049
6,264,168
Light SabreÔ Syringe

K981140

06/25/1998

5,810,841
6,096,049
6,264,168
Light SabreÔ Collimator

K013161

09/21/2001

5,810,841
6,096,049
6,264,168
Light SabreÔ Collimator (Master File)

MAF-1155

09/21/2001

5,810,841
6,096,049
6,264,168
DRTS® - Light Beam Patient Positron Indicator

K972852

09/15/1997

n/a
DRTS® Drape - Remote Control Drape

K973067

10/16/1997

n/a
Alignment verification devise

n/a

6,297,502
Removable Needle Rule

n/a

6,200,274
Method/device for subsurface target

To be filed

6,829,500

Anesthetic and Analgesic Drugs

Product Use Trade Name Approval Process Patent Number
Enflurane, USP Human Anesthetic Compound 347TM ANDA 74-396 n/a
Isoflurane, USP Human Anesthetic TerrellTM ANDA 74-416 n/a
Isoflurane, USP Veterinary Anesthetic AttaneTM ANADA 200-141-E0001 n/a

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Sevoflurane Human Anesthetic TBD To be filed 5,969,193
App#10/19/1999-pending
APP#10/644,500-pending
APP#60/628,708-pending
APP#60/628,707-pending
Conscious Sedation Human Use
Drug(s) and Device
TBD To be filed APP#10/272,794-pending

 

Anesthetic and Analgesic Devices

Trade Name

510(k) no.

510(k) Acceptance

Date

Patent Number

MR Tested Fiber Optic Laryngoscope Handle K970619 11/19/1997 6,036,639
6,444,358
6,056,415
MR Tested Fiber Optic Short Laryngoscope Handle K041852 11/15/2004 6,036,639
6,444,358
6,056,415
MR Tested Laryngoscope K971377 4/30/1998 6,036,639
6,444,358
6,056,415
MR Tested Flashlight K970747 5/20/1997
Carbon Dioxide Removal Human Anesthesia Equipment To be filed APP#60,559,659-pending

We also have a number of product approvals in other countries and expect additional approvals in the coming year.

Government Regulation

          We manufacture active anesthesia and analgesia ingredients, specifically the chemical synthesis of inhalation anesthetic compounds, and we produce finished anesthesia and analgesia products using the compounds manufactured at our facility in Bethlehem, PA. These manufacturing operations are regulated by the FDA and performed in compliance with cGMP as set out by the FDA. The facility is registered with the FDA as a pharmaceutical manufacturer and distributor. It is also registered as a pharmaceutical distributor with the states of Pennsylvania, Texas, Idaho and Kentucky. In addition, we believe that the operations at the Bethlehem facility are in compliance with the federal and state regulations regarding

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environmental protection, occupational safety and health, labor law, and state and local fire safety codes, building codes, and the covenants of the industrial park in which the facility is located. On average, the cost of environmental compliance at our Bethlehem facility averages between 1.75% and 2.25% of revenue generated by the facility.

          Our Buffalo facility houses the general headquarters personnel, the real-time image guidance system design and development technical staff, and the manufacturing operations associated with certain critical portions of our real-time image guidance systems. The facility also warehouses and distributes real-time image guidance systems. As such, the facility is registered with the FDA as a manufacturer and distributor of medical devices. We expect this facility to be registered under the EN13485 Device Directive in July 2005. Current activities at this facility are not subject to any federal, state or local environmental restrictions.

Employees

          As of June 30, 2005, we had 65 full time employees. None of our employees are represented by labor unions or covered by collective bargaining agreements. We have not experienced any work stoppages and consider our employee relations to be good.

Manufacturing

          At this time, we rely on third-party contract manufacturers to produce many of the components for our real-time image guidance system, SabreSourceTM. Critical sub-assemblies that involve proprietary materials and methods may be manufactured in-house or contracted out. Final device assembly is done at our Buffalo facility. Light SabreTM components are manufactured, assembled and sterilized by third parties (all of whom are ISO 9001 certified) and are subject to our acceptance.

          At our Bethlehem facility, we currently produce bulk isoflurane and enflurane, which are manufactured from raw materials. Upon completion of production, these anesthetics and analgesics are packaged on site into 100mL and 250mL bottles and prepared for distribution. We expect to begin producing and shipping sevoflurane by the end of 2005. We also have an existing contract under which we expect to sell desflurane as early as 2007.

Raw Materials

          Many of the raw materials used in our anesthesia and analgesia business are readily available from multiple sources. Four of the raw materials, however, are only available from a few suppliers. We have qualified three suppliers for each of CTFE ( chlorotrifluoro ethylene), CDFM (chloro difluoro methane) and TFE (trifluoro ethanol).  HFMOP (hexafluoro isopropyl methyl ether), used in making sevoflurane, is a custom synthesis and currently is available from only one source, the Daiken Industries, Ltd. plant in Japan. If we were unable to obtain HFMOP, we have the technology to produce this chemical; however, if we have to produce HFMOP it would require a significant capital investment and diversion of resources. Interruption in the supply of raw materials for anesthesia and analgesia synthesis could adversely affect our ability to supply finished product in the short-term. 

          For our real-time image guidance system business, there are multiple qualified suppliers for all components and outsourced services necessary to produce our real-time image guidance line of products.  

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Legal Proceedings      

          There are currently no material, pending legal proceedings against us or with respect to any of our property.

MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

 

          You should read the following description of our results of operations and financial condition in conjunction with the audited financial statements presented in the this prospectus.

Overview

Merger

          On December 16, 2004, we acquired Minrad Inc. through a reverse merger of our newly formed subsidiary into Minrad Inc., with the result that Minrad Inc. became our wholly owned subsidiary and the stockholders of Minrad Inc. became the beneficial owners of approximately 83% of our common stock. Because we did not have any substantial assets or operations during the two fiscal years prior to the acquisition, Minrad Inc. is deemed to be the accounting acquirer of Minrad International, and the discussion of operations below relates to the operations of Minrad Inc. References in this discussion to "fiscal 2003" are to Minrad Inc.'s fiscal year ended September 30, 2003, and references to "fiscal 2004" are to Minrad Inc.'s fiscal year ended September 30, 2004. On January 19, 2005, we changed our fiscal year end to December 31. On April 25, 2005, we reincorporated from the State of Nevada to the State of Delaware.

Company Background

          Through our wholly owned subsidiary, Minrad Inc., we operate an acute care business with two product lines: (1) real-time image guidance and (2) anesthesia and analgesia. We currently sell patented real-time image guidance technologies that enable medical professionals to improve the accuracy if interventional procedures and reduce the exposure to radiation. We recently launched SabreSourceTM, our second-generation real-time image guidance system. Our real-time image guidance products have broad applications in orthopedics, neurosurgery, interventional radiology and anesthesia. We manufacture and market our generic inhalation anesthetics for use in connection with human and veterinary surgical interventions. We are also developing a drug/drug delivery system for conscious sedation, which, similar to nitrous oxide used in dental surgery, provides a patient with pain relief without loss of consciousness.

Key Success Factors

          Four factors are the principal drivers of success in the MINRAD business model:

1) Expanded Product Commercialization including existing product growth in present and new markets and the development and introduction of new products.
2) Manufacturing Efficiency facilitating maximum margin realization.
3) The Attraction of Talented Personnel accelerating product and market plan implementation.

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4) Funding of the Business to insure successful on-going operations.

          Each of these success factors will be addressed in the discussion of operations.

Results of Operations -- Quarter ended March 31, 2005 compared to quarter ended March 31, 2004

          Progress against our key success factors during the period included the launch of SabreSourceTM at the American Academy of Orthopedics in February, improved capacity utilization in the second half of the quarter following a $2.5 million bridge financing (see liquidity and capital), and the addition of Bill Bednarski as Executive Vice President & COO.

          The following table compares the results of our operations for the quarters ended March 31, 2005 and March 31, 2004.

     

Increase/

Percent

 

2005

2004

(Decrease)

Change

                 
Revenue

$

2,429,000

$

878,000

$

1,551,000

177

%

         
Gross Margin

1,158,000

219,000

939,000

429

%

Gross Margin %

47.7%

24.9%

22.8 pts

 
         
Research and Development

338,000

234,000

104,000

44

%

Sales and Marketing

309,000

181,000

128,000

71

%

Finance and Administration

652,000

391,000

261,000

67

%

         
Operating Loss

(141,000)

(587,000)

(446,000)

(76

%)

         
Interest Expense: Cash

(89,000)

(116,000)

(27,000)

(23

%)

           
Interest Expense: Non-cash

(665,000)

(826,000)

(161,000)

(19

%)

         
Net Loss

$

(895,000)

$

(1,529,000)

$

(634,000)

(42

%)

                 
EPS

$

(0.03)

$

(0.10)

$

0.07

70

%

 

Revenue

        The increase in revenue of $1,551,000 came from both the North American and International sales areas. North American sales increased to $814,000 in the March 31, 2005 quarter, compared to $181,000 in the same period in 2004. This represents a $633,000 increase or 350%. International sales volume grew to $1,615,000, a $918,000 increase or 131% from the same period a year ago.  The major increase is in China, Venezuela and Argentina.

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Gross Margin

        The gross margin improved $939,000 or 22.8 percentage points. In large part this was due to higher revenue volume absorbing fixed overhead combined with a more efficient manufacturing operation in the quarter ended March 31, 2005 compared to the quarter ended March 31, 2004. Our margins should continue to improve as we continue to increase our revenue volume from new product sales.

Research & Development

        The increase in research and development of $104,000 largely reflects increased headcount related to the expanding image-guided product line.

Sales & Marketing

        The increase in Sales and Marketing expense of $128,000 can be primarily attributed to the following: $20,000 of the increase was volume related commissions, incentives and distribution expense; $24,000 was convention expense incurred in association with the launch of the SabreSourceTM system; and $57,000 of the increase was related to headcount additions to support our anesthesia and analgesia contracts.

Finance & Administration

        The year over year increase of $261,000 was largely driven by outside legal and accounting services, which can be attributed to the reverse merger consummated in December 2004, resulting in increased public company compliance costs.  Wages increased by $68,000 as a result of the addition of administrative personnel.

Interest Expense: Cash

        Interest Expense: Cash declined sharply between periods reflecting the company's fund raising efforts in calendar 2004, which were undertaken to repay debt. Out-of-pocket interest expense in the quarter ended March 31, 2005 was $89,000 compared to $116,000 in the same period a year earlier, a 23% reduction in expense.

Interest Expense: Non-cash

        The Company booked $665,000 in imputed (non-cash) interest expense in the quarter ended March 31, 2005 attributed to beneficial conversion features on debt and warrants issued in connection with debt instruments. Imputed interest is the fair market value of the securities, in this case warrants issued. Approximately $500,000 of the imputed interest was related to warrants issued to Kevin Kimberlin Partners in association with its guarantee of a $1 million working capital line; $165,000 was incurred in association with the $2.5 million bridge financing (see liquidity and capital below).

Net Loss

        The Net Loss for the quarter ended March 31, 2005 was $(895,000) a decrease of $634,000 or 42% from the prior year of $(1,529,000).  This is primarily attributed to the increase in revenue, volume, and gross margin.

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Results of Operations - Three month period ending December 31, 2003 compared to the three month period ending December 31, 2004:

Increase/

2003

2004

(Decrease)

%

Revenue

$ 1,049,362

$ 460,276

$(589,086)

(56%)

Gross Margin

143,506

(156,115)

(299,621)

(209%)

Gross Margin %

13.6%

(33.9%)

(47.6) pts

(2880%)

Research and development

368,026

308,670

(59,356)

(16%)

Sales and marketing

193,680

230,348

36,668

19%

Finance and administration

454,523

486,970

32,447

7%

Operating loss

(872,723)

(1,182,103)

(309,380)

(35%)

Interest expense

276,481

198,280

(78,201)

(28%)

Net loss

$(1,149,204)

$(1,380,383)

$231,179

20%

 

Net Revenue

          For the quarter ended December 31, 2004, the company generated revenue of $460,276 as compared to $1,049,362 for the quarter ended December 31, 2003. The decrease of $589,086, or 56%, was not reflective of market conditions as we ended the quarter with $1,037,000 in immediately shippable backlog. Rather the decrease reflected delays resulting from the completion of previously mentioned sevoflurane validation batches which postponed our resumption of isoflurane production.

          Customer impact of these backlogs was partially mitigated by our ability to work with the various parties and balance their inventory levels. We will be continuing this practice through the end of the first calendar quarter ending March 31, 2005 when we expect to have shipped the backlog from the prior quarter.

Gross Profit

          Gross Profit for the quarter ended December 31, 2004 was ($156,115) as compared with $143,506 for quarter ended December 31, 2003, representing a reduction of $299,621. Gross margin was (33.9%) as compared with 13.7% in the prior period. The unfavorable gross margin variance in the quarter ended December 31, 2004 was a function of lower volumes due to the plant's inactivity during the sevoflurane validation campaign. The lower volumes resulted in unfavorable manufacturing absorption variances of $406,200.

          Shipment of the $1,037,000 in immediately shippable backlog during the quarter ended December 31, 2004 would have had a positive impact on gross profit for this period. We expect to experience fluctuations in gross margins in future periods, primarily resulting from fluctuations in production volume based on increasing demand and the introduction of new products during 2005.

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Research and Development

          Research and development expenses for the quarter ended December 31, 2004 were $308,670, representing a reduction of $59,356, or 16%, from the period ended December 31, 2003. The year-over-year decrease is composed of a timing-related reduction in prototype expenses of $96,525. Partially offsetting this were increased wage and benefit expenses of $50,788 which were related to additional personnel in the image-guidance engineering staff.

          During the quarter, the company was awarded one additional U.S. patent for a stereo tactic device used in neuro surgical procedures that will provide future product opportunities. Also received was a 510(k) device clearance for a modification to a Laryngoscope Handle.

Sales and Marketing

          Sales & Marketing expense increased from $193,680 in the quarter ended December 31, 2003 to $230,348 in the quarter ended December 31, 2004. This $36,668 or 19% increase is primarily attributed to trade show expenses associated with the introduction of our new SabreSource technology.

Finance and Administration

          Finance and Administration costs increased $32,447 from $454,523 in the quarter ended December 31, 2003 to $486,970 in the quarter ended December 31, 2004. On an on-going basis, Finance and Administration costs increased by approximately $218,000 from $379,000 in the quarter ended December 31, 2003 to approximately $597,000 in the quarter ended December 31, 2004, a 58% increase. Three main factors contributed to the increase in Finance and Administration expenses: $126,000 in additional wages and benefits, $90,000 in legal and accounting expenses, and $43,000 in increased insurance costs. Most of these increased costs relate to the cost to comply with being a public company. In addition, the Company reserves for bad debt expense based on specific identification of doubtful accounts. In the quarter ended December 31, 2003, the Company recognized $75,000 as bad debt expense, versus a $110,000 bad debt recovery that occurred in the quarter ended December 31, 2004. This $185,000 difference between periods offset a large portion of the increase in other Finance and Administration costs.

Interest Expense

          Interest Expense declined from $276,481 in quarter ended December 31, 2003 to $198,280 in the quarter ended December 31, 2004. This reduction of $78,201 is a result of the reduction in debt following the conversion of short-term demand notes to equity during March of 2004. Interest levels in calendar 2005 are undeterminable at this time. Management's intentions, which are dependent upon future funding, are to lower cash based interest expense through reductions in factoring, mortgage and other liabilities. Interest of a non-cash nature should increase due to valuations of two groups of warrants. The first is associated with the guarantee of the $997,000 Wachovia line of credit. The second is the amortization of the warrants associated with the $2.5 million convertible debt financing in February 2005. Additional non-cash basis interest expense is also possible if conditions are met that allow for the conversion to common stock of this same $2.5 million debt.

Net Loss

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          The net loss for the quarter ended December 31, 2004 was $1,380,383 an increase of $231,179 or 20% from the $1,149,204 net loss recorded in the quarter ended December 31, 2003. The major contributors to the loss recorded in the quarter ended December 31, 2004 were a $299,621 reduction in gross margin partially offset by a reduction in interest expense of $78,201.

Results of Operations -- Year Ended September 30, 2003 Compared to Year Ended September 30, 2004

 

2003

 

2004

 

Increase/
(Decrease)

 

%

Revenue

3,514,963

 

4,116,995

 

602,032

 

17%

Gross Margin

1,422,980

 

966,516

 

(456,464)

 

(32%)

Gross Margin %

40%

 

23%

 

(17%)

 

(43%)

Research and development

1,269,842

 

1,175,570

 

(94,272)

 

(7%)

Sales and marketing

645,805

 

736,266

 

90,461

 

14%

Finance and administration

1,550,259

 

2,097,288

 

547,029

 

35%

Interest expense

752,591

 

789,443

 

36,852

 

5%

Debt conversion costs

-

 

713,000

 

(713,000)

 

n/a

Net Loss

(2,795,517)

 

(4,545,051)

 

1,749,534

 

63%

Revenue

   

2003

 

2004

 

Increase/
(Decrease)

 

%

North America $

909,305

$

1,155,315

$

246,010

 

27%

International $

2,605,658

$

2,961,680

$

356,022

 

14%

Total $

3,514,963

$

4,116,995

$

602,032

 

17%

          Revenue increased by $602,032, or 17%, to $4,116,995 for fiscal 2004 from $3,514,963 for fiscal 2003. North America showed the greater year-over-year percentage improvement. Essentially, all revenue was from our anesthesia and analgesia line. North American sales rose sharply in the human inhalant anesthetic market due primarily to net sales of approximately $385,000 in the quarter ended September 30, 2004, generated from our partnership with RxElite, Inc. Exclusive of the one-time license fee for real-time image guidance of $150,000 received in fiscal 2003, North American revenue increased by $396,010, or 52%, to $1,155,315 for fiscal 2004 from $759,305 for fiscal 2003.

          International sales increased by 14% for fiscal 2004 from fiscal 2003. Sales growth generally was uniform across our sales regions with 14% growth in each of Europe and the Pacific Rim, and 13% growth in Latin America. Our international business benefited from increases in market share in the United Kingdom, Brazil and Argentina, and the entry into the Thailand market and the veterinary markets of Switzerland and Australia. Factors reducing growth in the various markets included a slow down in sales to the Middle East as a result of anti-American sentiments related to the war in Iraq, a decline in sales in South Korea attributable to declining demand, and the required cessation of sales to Venezuela as a result of export exchange control issues. Subsequent to fiscal 2004, we believe we have resolved the export exchange control issues in Venezuela by identifying alternative distribution channels that provide requisite import and export credits.

Gross Margin

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          Gross margin declined by $456,464, or 32%, to $966,516 for fiscal 2004 from $1,422,980 for fiscal 2003, primarily as a result of sharply higher manufacturing variances in fiscal 2004.

          In fiscal 2004, unfavorable manufacturing variances increased by $697,341, or 127%, to $1,248,297 from $550,956 for fiscal 2003. Roughly $500,000 of the fiscal 2004 variance represented lost production associated with modifications to our Bethlehem facility to allow for the production of sevoflurane. The balance is comprised of under-absorbed overhead and the cost of hiring and training additional staff in anticipation of continuous operations commencing in 2005. The hiring and training of staff for a third shift generated $200,000 of one-time costs. The unfavorable variance of $550,956 in fiscal 2003 was reduced by the receipt of a $500,000 progress payment from Chubb on a business interruption claim filed in connection with storm damage that negatively affected production at the Bethlehem facility from February 16, 2003 to mid-July 2003.

          Specialty anesthesia and analgesia facilities have intrinsically high fixed overhead costs. Quality control, health, safety and environmental management, process engineering and maintenance, and management are all required on-site. If production at our Bethlehem facility slows due to new product qualification, business interruption, reduced volume or expansion, the impact on our results can be severe.

          In fiscal 2004, we invested in the future of our business. We performed the initial synthesis and process controls for sevoflurane, a process that we completed with our validation batches in December 2004. Because of the manner in which we use equipment in the facility for multiple purposes, the sevoflurane projects resulted in substantial downtime in 80% of our production capacity. In addition, we began to hire and train staff in January 2004 which qualified us to move to continuous operation. We expect that we will begin to see the benefits from continuous operation and the related overhead absorption in the first calendar quarter of 2005. Further, we anticipate the validation batches of sevoflurane will become saleable in the second quarter of 2005.

Research and Development

          Research and development expenses declined by $94,272, or 7%, to $1,175,570, or 29% of revenue, for fiscal 2004, from $1,269,842, or 36% of revenue, for fiscal 2003. Research and development costs were essentially flat between periods. We expect to continue to spend significant amounts on research and development to fund our core product lines, new products and technology development in 2005 and beyond.

Sales and Marketing

          Sales and marketing expenses increased by $90,461, or 14%, to $736,266 for fiscal 2004 from $645,805 for fiscal 2003. As a percentage of product sales, costs remained relatively consistent at 18% of sales between periods. We expect that in future periods, sales and marketing expenses, as a percentage of sales, will exceed the fiscal 2003 and 2004 levels as a result of our need to support contractual commitments for inhalation anesthetics with additional personnel and significant initial costs associated with the launch of SabreSourceTM.

Finance and Administration

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          Finance and administration expenses increased by $547,029, or 35%, to $2,097,288 for fiscal 2004 from $1,550,259 for fiscal 2003. The increase was attributable primarily to an increase in audit, legal and professional expenses of approximately $757,000 associated mainly with the merger of Minrad Inc. into our company, and increased expenses of $125,000 associated primarily with an increased headcount in our financial department. These increases were offset partially by a $131,000 decline in bad debt expense for fiscal 2004.

Interest and Debt Conversion Costs

          Interest expense increased by $36,852, or 5%, to $789,443 for fiscal 2004 from $752,591 for fiscal 2003. Included in fiscal 2004 interest expense was $123,000 in non-cash interest costs associated with convertible debt. In fiscal 2004, we incurred interest expenses of approximately $294,000 in connection with a factoring arrangement. In addition, we incurred $713,000 in debt conversion costs related to the conversion of $3,026,000 of debt into equity at an average price per share of $0.79 in March 2004. The average conversion price was below the stated conversion price and, as a result, we booked a non-cash debt conversion cost.

Net Loss

          Net loss increased by $1,749,534, or 63%, to $4,545,051 for fiscal 2004 from $2,795,517 for fiscal 2003. This increase in net loss is due primarily to lower gross margins, increase in finance and administration costs, and a one-time, non-cash debt conversion cost, each as discussed above.

Stockholders' Equity

          The combination of fund raising and debt conversion, offset by our losses, over the period contributed to a net improvement in our stockholders equity of $2,881,000, or 49%, from $(5,887,000) in fiscal 2003 to $(3,006,000) in fiscal 2004. In evaluating tangible net worth, however, it should be considered that the anesthesia and analgesia Bethlehem facility is recorded on our books at approximately $355,000, reflecting the fact that the purchase in December 2000 for $1.4 million generated no recorded value on our books for the building and equipment.

Liquidity and Capital as of July 1, 2005

        Between June 10, 2005 and July 1, 2005, we sold an aggregate of 11,260 shares of Series A convertible preferred stock and warrants to purchase 2,815,000 shares of common stock for an aggregate price of $11.26 million, which yielded net proceeds to us of approximately $8.8 million.  We do not currently have any permanent arrangements or credit facilities in place as a source of funds.  We are currently negotiating to obtain a $5 million line of credit.  We also expect to seek additional funds in the future through private placements or public sales of equity securities or the incurrence of additional indebtedness.  If we fail to obtain sufficient additional capital in the future, we could be forced to curtail our growth strategy by reducing or delaying capital expenditures and acquisitions, selling assets, or downsizing or restructuring our operations.

Liquidity and Capital at March 31, 2005

        As of March 31, 2005, we had current assets of approximately $3.2 million, including cash of $135,000, and current liabilities of approximately $6.5 million.

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        Net cash used by operating activities increased from $638,000 in the quarter ended March 31, 2004 to $1,762,000 in the quarter ended March 31, 2005. This increase of approximately $1,124,000, or 176%, was largely attributable to an increase in accounts receivable of $1,037,000 due to revenue growth. Net cash used by investing activities increased from $25,000 in the prior period to $108,000 in the quarter ended March 31, 2005, an increase of $83,000 or 332%. This was primarily due to an increase in the purchase of property and equipment of $55,000.

        Cash provided by investing activities increased by $1,765,000 from $237,000 to $2,002,000 in the quarter ended March 31, 2005. This included a bridge loan for $2.5 million partially offset by the repayment of $474,000 in demand notes payable and legal costs related to the financing of $218,000.

        We issued convertible promissory notes to the Tobin Family Trust ($1.5 million aggregate principal amount) and Laird Cagan ($1 million principal amount) in February 2005. These notes payable of $2,500,000 are due October 7, 2005. They are reflected net of a discount of $760,000 to a net carrying value of $1,739,000 at March 31, 2005. This discount is due to 375,000 detachable warrants issued with the loan with a value of $925,000. The discount is being amortized over the life of the loan, with $165,000 expensed in the first quarter.

        In May 2005 the parties to this bridge loan signed an amendment altering certain terms of the agreement. The Lenders now have the right to accelerate payment or to convert all or any portion of the outstanding principle and accrued interest into common stock at the conversion price of $1.75 in the event the Company's outstanding bank borrowings exceed $5,000,000. The Company has the right to pre-pay after 7 business days if bank borrowings exceed $5,000,000.

        Our future capital requirements are expected to be substantial. Most notably, we desire to expand our Bethlehem facility to allow for anticipated future growth of production. We expect to incur incremental costs related to our real time image guidance system and research and development costs for conscious sedation. Accordingly, we will need to raise additional funds in the future through the private or public sales of equity securities or the incurrence of additional indebtedness. Additional funding may not be available on terms favorable to us, or at all. If we raise additional funds through the issuance of equity securities, the percentage ownership of our stockholders will be reduced; stockholders may experience dilution and the issued equity securities may provide for rights, preferences and privileges senior to those of the existing holders of our common stock. In addition, any issuance of indebtedness may require us to comply with restrictive covenants. Our inability to raise additional capital would have a material adverse effect on our results of operations and financial condition.

Liquidity and Capital Resources at December 31, 2004

          As of December 31, 2004, we had current assets of approximately $2.2 million (including nominal amounts of cash) and current liabilities of approximately $6.1 million. As of December 31, 2003, we had current assets of approximately $1.8 million, including cash and equivalents and restricted cash of approximately $426.0 thousand and current liabilities of approximately $9.6 million. The net improvement in working capital of approximately $3.8 million is attributed primarily to the conversion of approximately $3.0 million of short-term demand notes into equity.

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          Net cash used by operating activities increased by approximately $625.0 thousand, or 228% from approximately $274.0 thousand for the quarter ended December 31, 2003 to approximately $899.0 thousand for the quarter ended December 31, 2004. This increase was attributable primarily to the increased net loss from operations of approximately $231.0 thousand and reduced levels of cash generated from changes in working capital of approximately $325.0 thousand . Net cash used by investing activities for the quarter ended December 31, 2004 was $52.0 thousand, a decrease of approximately $383.0 thousand from the $435.0 thousand experienced in the quarter ended December 31, 2003. This was primarily due to a short term investment of $350.0 thousand at December 31, 2003 generated from initial equity investments which was subsequently expended in operations. There also was approximately a $40.0 thousand reduction in purchases of property and equipment. Net cash provided by financing activities increased by approximately $168.0 thousand from approximately $785.0 thousand at December 31, 2003 to approximately $953.0 thousand at December 31, 2004. This increase was largely due to debt repayments of $106.0 thousand in the quarter ended December 31, 2003. In the quarter ended December 31, 2004, we raised approximately $971.0 thousand through borrowings under demand notes payable as opposed to approximately $925.0 thousand in the fourth quarter in 2003.

          Our future capital requirements will be substantial. Most notably, we must expand our Bethlehem facility to produce in a timely manner the quantities of enflurane, isoflurane, sevoflurane and desflurane that international sales partners are required to purchase in the future under existing contracts to maintain exclusivity in their respective sales regions. See "Anesthesia and Analgesia Competitive Strategy." We expect to incur substantial costs related to our real time image guidance system and research and development costs for conscious sedation. Accordingly, we will need to raise additional funds in the future through the private or public sales of equity securities or the incurrence of additional indebtedness. Additional funding may not be available on terms favorable to us, or at all. If we raise additional funds through the issuance of equity securities, the percentage ownership of our stockholders will be reduced, stockholders may experience dilution and the issued equity securities may provide for rights, preferences and privileges senior to those of the existing holders of our common stock. In addition, any issuance of indebtedness may require us to comply with restrictive covenants. Our inability to raise additional capital would have a material adverse effect on our results of operations and financial condition.

Liquidity and Capital Resources at September 30, 2004

          As of September 30, 2004, we had current assets of approximately $1.8 million, including nominal amounts of cash, and current liabilities of approximately $5.4 million. As of September 30, 2003, we had current assets of approximately $2.2 million, including nominal amounts of cash, and current liabilities of approximately $8.5 million. The net improvement in working capital of approximately $2.7 million is primarily attributed to the conversion of approximately $3 million of short-term demand notes into equity.

          Net cash used by operating activities increased by approximately $1.3 million, or 76%, to approximately $3.0 million for fiscal 2004 from approximately $1.7 million for fiscal 2003. The increase in net cash used by operating activities was attributable primarily to the increase in the net loss from operations of approximately $1.7 million, which was offset by the one-time, non-cash charge for debt conversion costs of approximately $713.0 thousand, and improvements in cash flow on payments of accounts receivable of approximately $970.0 thousand as a result of the utilization of a factoring company.

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          Net cash used by investing activities for fiscal 2004 was approximately $299.0 thousand. For fiscal 2003, investing activities provided net cash of approximately $411.5 thousand. The additional use of cash by investing activities for fiscal 2004 was due primarily to purchases of property and equipment and costs associated with patent applications.

          Net cash provided by financing activities increased by approximately $2.0 million, or 156%, to approximately $3.3 million for fiscal 2004 from approximately $1.3 million for fiscal 2003. In fiscal, 2004, we raised approximately $3.6 million through private sales of common stock. We also made payments of approximately $1.2 million on outstanding indebtedness, while borrowing approximately $873.0 thousand under demand notes, including our accounts receivable factoring program, which we instituted in fiscal 2004 that yielded approximately $161.4 thousand. In fiscal 2004, our financing activities consisted primarily of borrowings and repayments under demand notes.

          Subsequent to September 30, 2004, in the three months ended December 31, 2004, we raised net proceeds of approximately $1.2 million through private sales of common stock. In addition, on February 8, 2005, we raised $2.5 million through the private sale of convertible promissory notes and warrants to purchase common stock. The proceeds of those sales have been and will be used to fund ongoing operations.

Critical Accounting Policies And Estimates

          The preparation of consolidated financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. On an on-going basis, we evaluate our estimates. We base our estimates on current information, historical experience and on various other assumptions that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ from the estimates we used under different assumptions or conditions. We believe the following concentrations and critical accounting policies relate to our more significant judgments and estimates used in the preparation of our consolidated financial statements.

          Allowance for Doubtful Accounts

          We maintain an allowance for doubtful accounts for estimated losses resulting from the inability of our customers to make required payments. We make a similar allowance for accounts receivable that we have sold with recourse to a financial institution. Our accounting for doubtful accounts contains uncertainty because management must use its judgment to assess the collectibility of these accounts. When preparing these estimates, management considers a number of factors, including the aging of a customer's account, past transactions with customers, creditworthiness of specific customers, historical trends and other information. We review our accounts receivable reserve policy monthly, based on current risks, trends and changes in industry conditions. The allowance for doubtful accounts was approximately $317,000 at December 31, 2004, and approximately $420,000 at September 30, 2004. Although we believe this allowance is sufficient, if the financial condition of our customers were to unexpectedly deteriorate, resulting in an impairment of their ability to make payments, additional allowances may be required that could materially impact our consolidated financial statements. Concentrations of credit risk can impact this risk considerably. Approximately 56% of our revenues for the quarter ended December 31, 2004, and approximately 72% of our revenues in fiscal 2004 were

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derived from our customers located in foreign countries where it may be difficult or impossible to commence legal proceedings to collect past due accounts, a situation that would impact collect ability. In addition, for fiscal 2004 six customers comprised 58% of our revenues, a circumstance that increases our collection risks.

          Inventory Valuation

          Inventory is stated at the lower of cost or market using the first-in, first-out accounting method. As a part of the valuation process, excess, slow-moving and damaged inventories are reduced to their estimated net realizable value. Our accounting for slow-moving and damaged inventory contains uncertainty because management must use judgment to estimate when the inventory will be sold and the quantities and prices at which the inventory will be sold in the normal course of business. We review our changes in industry conditions. We had established valuation reserves associated with slow-moving inventory of approximately $725,000 at December 31, 2004.

          Property, Equipment and Depreciation

          Depreciation is computed over the estimated useful life of three to five years using the straight-line depreciation method. Long-lived assets to be held and used by the Company are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. We continuously evaluate the recoverability of our long-lived assets based on estimated future cash flows from and the estimated fair value of such long-lived assets, and provide for impairment if such undiscounted cash flows are insufficient to recover the carrying amount of the long-lived asset.

          Patents

          Patent application costs in excess of $1,000 on patents that generate incremental revenue are carried at cost and will begin to be amortized when placed in service. As of December 31, 2004, the carrying value of capitalized patents were approximately $65,000. The patents will be amortized over their estimated useful lives. The carrying value of patents is periodically reviewed and impairments, if any, are recognized when the expected future benefit to be derived from an individual patent is less than its carrying value.

          Income Taxes

          We have recorded deferred tax assets relating to net operating loss carryforwards for United States federal and state tax purposes, tax credit carryforwards and non-deductible reserves, among other items. We recorded a valuation allowance equal to 100% of the carrying value of our net deferred tax assets to reduce our deferred tax assets to the amount that is more likely than not to be realized. While we have considered future taxable income and ongoing tax planning strategies in assessing the need for the valuation allowance, in the event we were to determine that we would be able to realize our deferred tax assets in the future in excess of their net recorded amounts, a resulting reduction of the valuation allowance would increase our income in the period the determination was made. At December 31, 2004, we had approximately $10.1 million in gross deferred tax assets, which were fully offset by a valuation allowance.

          Revenue Recognition

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          We recognize revenue from product sales when the goods are shipped to the customer and title has been transferred. We do not engage in bill and hold transactions and do not enter into inventory consignment agreements. If we enter into the future sale of licenses, we will classify all revenue that involves the future sale of a licensee's products as royalty revenue. Royalty revenue will be generally recognized in the quarter in which a report is received from a licensee detailing the shipments of products incorporation our intellectual property components. License fees will be recognized upon the execution of the license agreement and transfer of intellectual property, provided no further significant performance obligations exist and collectibility is deemed probable.

          Research and Development Costs

          All costs related to research and development are expensed as incurred. These costs include labor and other operating expenses related to product development, as well as costs to obtain regulatory approval.

          Stock Based Compensation

          In the past several years we have issued warrants and options to non-employees for services and in connection with obtaining debt. We have recognized significant expense relating to the issuance of these equity instruments. We estimated the fair value of those securities using the Black-Scholes warrant and option pricing model, and expensed the estimated fair value over the service period or through the debt maturity date. The Black-Scholes model uses critical assumptions that significantly affect the estimated fair value of those awards, such as an estimated volatility factor of our common stock and the estimated lives of the awards (which is equal to the maximum contractual term for awards to non-employees). Additionally, as further discussed below under "Recent Accounting Pronouncements," we are required to recognize compensation expense on options issued to employees beginning in 2006, and we expect that we will use similar estimation methods. Changes in the volatility of our common stock and other estimation factors used in the Black-Scholes model can significantly impact the estimated value and resultant compensation cost on similar equity instruments issued in the future.

Recent Accounting Pronouncements

          In December 2004, the FASB issued SFAS 151, "Inventory Costs." This Statement amends the guidance in Accounting Research Bulletin No. 43, Chapter 4, "Inventory Pricing," to clarify accounting for abnormal amounts of idle facility expense, freight, handling costs and wasted material (spoilage). SFAS 151 requires that those items be recognized as current period charges regardless of whether they meet the criterion of "so abnormal." In addition, this Statement requires that allocation of fixed production overheads to the costs of conversion be based on the normal capacity of the production facilities. Statement 151 is effective for inventory costs incurred during fiscal years beginning after June 15, 2005, with earlier application permitted in certain circumstances. Adopting this new standard is not expected to have a significant impact on the Company's financial statements.

          In December 2004, the FASB issued SFAS No. 123 (revised 2004), "Share-Based Payment" ("SFAS 123R"). SFAS 123R revised SFAS No. 123 and supersedes Accounting Principles Board Opinion No. 25, and its related implementation guidance. SFAS 123R establishes standards for the accounting for transactions in which an entity exchanges its equity instruments for goods or services. It also addresses transactions in which an entity incurs liabilities in exchange for goods or services that are

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based on the fair value of the entity's equity instruments, or that may be settled by the issuance of those equity instruments. SFAS 123R focuses primarily on accounting for transactions in which an entity obtains employee services in share-based payment transactions. SFAS 123R does not change the accounting guidance for share-based payment transactions with parties other than employees provided in SFAS 123 as originally issued, and as set forth in EITF Issue No. 96-18, which we already follow.

          SFAS 123R requires a public entity to measure the cost of employee services received in exchange for an award of equity instruments based on the grant-date fair value of the award (with limited exceptions) and to recognize that cost over the period during which an employee is required to provide service in exchange for the award (usually the vesting period). Currently, we use the intrinsic value method for accounting for employee stock options and include a pro forma disclosure, as allowed by SFAS No. 123, for this estimated compensation cost on employee stock options.

          As a small business issuer, we are required to adopt SFAS 123R on January 1, 2006. SFAS 123R applies to all awards granted after the required effective date and to awards modified, repurchased or cancelled after that date. Because the statement was recently released, we have not yet assessed the potential impact of the adoption of SFAS 123R on our financial position or results of operations.

DIRECTORS AND EXECUTIVE OFFICERS

          The following table identifies our directors and executive officers.

  Name Age Position
  William H. Burns, Jr. 55 Chairman of the Board, President and Chief Executive Officer
  David DiGiacinto (1) 50 Director
  David Donaldson (2) 60 Director
  Donald Farley (3) 62 Director
  Duane Hopper (1) (2) 58 Director
  Robert Lifeso (2) (3) 60 Director
  John Rousseau (2) (3) 61 Director
  William L. Bednarski 50 Executive Vice President and Chief Operating Officer
  John McNeirney 72 Senior Vice President and Chief Technology Officer
Kirk Kamsler 54 Senior Vice President of Commercial Development
  Richard Tamulski
_______________________
58 Vice President of Finance
  (1) Compensation Committee member

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  (2) Audit Committee member
  (3) Corporate Governance Committee member

          William H. Burns, Jr. has served as Chairman and Chief Executive Officer of Minrad since its inception in 1994. Prior to founding Minrad, Mr. Burns was President and Chief Executive Officer of Matrx Medical from 1988 to 1994. Prior to that, he spent 13 years with the BOC Group in progressive management positions including Vice President of Marketing of Anaquest, the developers of inhalation technology. He is a two-time recipient of the Industry/University Technology Discovery Award. He earned a BBA at St. Norbert College and an MBA at Marquette University.

          David DiGiacinto has served as a director of Minrad since 2002. Mr. DiGiacinto joined Spencer Trask Specialty Group LLC in 2000 and is currently a Senior Managing Director. Before joining Spencer Trask he spent 18 years at Pfizer, Inc. and six years as a captain in the U.S. Air Force. Mr. DiGiacinto also currently serves on the Board of Directors of three other companies, each of which is privately-held. He is a graduate of the United States Military Academy at West Point.

          David Donaldson has served as a director of Minrad since 2004. Since 1970, Dr. Donaldson has served as a professor of Dentistry at the University of British Columbia, Canada, where he is currently the head of the Department of Oral Biological and Medical Sciences. He has chaired two other departments since 1970, including Oral Maxillo Facial Surgery and Oral Surgical and Medical Science. Dr. Donaldson previously held the position of Director of Pain and Anxiety control in the Faculty of Dentistry, an area in which he is considered an expert and in which he has published extensively. He received his BDS at St. Andrews University, Scotland in 1965. Dr. Donaldson completed his Fellowship in Dental Surgery through the Royal College of Surgeons, Edinburgh, Scotland in 1969 and received his Masters degree in Prosthodontics from Dundee University in 1971.

          Donald Farley has served as a director of Minrad since 2002. For more than five years, Mr. Farley has served as Chief Executive Officer of SpencerTrask Ventures, an affiliate of Spencer Trask Specialty Group LLC. Prior to joining Spencer Trask, Mr. Farley held numerous positions at Pfizer, Inc. over a thirty-year period, culminating in his position as President of the Consumer Health Care Group. Mr. Farley currently serves on the Board of Directors of other companies, including Westgate Biologics located in Ireland. He holds a BS in Chemical Engineering from the University of Rhode Island and a MBA from the University of Hartford.

          Duane Hopper, has served as a director of Minrad since 2004. Since 1998, Mr. Hopper has been a private consultant in the medical device industry. He was President, Chief Executive Officer and Chief Operating Officer of Graphic Controls Corporation from 1992 until 1998, when it was acquired by Tyco International, Inc. Prior to that time period, he was Vice President and General Manager of the Medical Products Division of Graphic Controls Corporation from 1988 until 1992.  He served in executive positions with other medical products companies during the 1970s and 1980s including, Air Products and Chemicals, Inc., Zimmer, Inc., Surgilase, Inc., and Ohmeda, Inc. He earned a Masters in Management Degree from the Kellogg Graduate School of Management at Northwestern University in 1974 and Bachelor's Degree in Biology from the University of Virginia in 1968.  He served as an officer in the U.S. Air Force from 1968 until 1972, including one year as a combat aircrew member in Southeast Asia.

          Robert Lifeso, MD, is a co-founder of Minrad and has served as a director of the company since 1994. For more than five years, he has served as the Director of the Spine Center at Erie County Medical Center in Buffalo, New York. Previously, Dr. Lifeso served as Chief of Orthopedic Surgery at the

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Veterans Hospital in Buffalo as well as the King Faisal Hospital in Saudi Arabia. He received his FRCSC and MD from the University of Toronto and has published over 60 peer-reviewed articles.

          John Rousseau has served as a director of Minrad since 2002 and is a Managing General Partner of New England Partners Capital, LLC. Prior to co-founding New England Partners in 1995, Mr. Rousseau held senior management positions with Homart Development (Sears), Spaulding & Slye and Associated Project Control. Prior to holding these positions, Mr. Rousseau practiced law for 15 years and was a senior partner at the law firm of Hale and Dorr in Boston, Massachusetts. He has a BA from Amherst College and an LLB from Columbia University.

          William L. Bednarski became our Executive Vice President and Chief Operating Officer on February 16, 2005. Prior to joining us, Mr. Bednarski worked for Nellcor, Inc., a manufacturer of oximetry and critical care products and related medical monitoring that is a division of Tyco International, Inc., since 1993, most recently as its Vice President of OEM and Licensing Technology, since 2001. From 1989 to 1993, Mr. Bednarski was Director of Business Development at the Ohmeda Monitoring Group of BOC, Inc. Prior to entering the medical device industry, Mr. Bednarski spent nine years in financial management positions beginning as a Financial Analyst at Ford Motor Company and serving as Controller of a division of Otis Elevator Corporation and of Alpha Wire Corporation. Mr. Bednarski has a BA from Harvard University and has an MBA in Finance from the Wharton School of Business at the University of Pennsylvania.

          John McNeirney has served as the Senior Vice President and Chief Technology Officer of Minrad since he joined the company in August 1996. Prior to joining Minrad, Mr. McNeirney served in various senior executive positions in health care with the BOC Group from 1983 to 1992, Richardson-Vick from 1975 to 1983, and The Upjohn Company from 1964 to 1972. Mr. McNeirney has authored 56 U.S. patents and holds a BS in Chemical Engineering and an MS in Microbiology from Carnegie Mellon University.

          Kirk Kamsler has served as Senior Vice President of Commercial Development of Minrad since June 1, 2004 and has served in various other sales and marketing positions since he joined Minrad in October 1999. From 1996 to 1999, Mr. Kamsler served as the Vice President of Sales and Marketing of Cardiac Controls. He also has held senior marketing and sales positions with Marquette Electronics from 1989 to 1996, Matrx Medical from 1985 to 1989, and Davis & Geck from 1981 to 1984. Mr. Kamsler is a graduate of St. Lawrence University.

          Richard Tamulski has served as Minrad's Vice President of Finance since April 7, 2004 and served as Controller from April 2003 through April 2004. Mr. Tamulski was President, Chief Executive Officer and Chief Operating Officer of Brand Names, a catalog and showroom retailer, from 1996 to 2002. Prior to that, Mr. Tamulski served as the Vice President of Finance of Brand Names from 1989 to 1995. He has 25 years of experience in finance beginning with a predecessor of KPMG LLP. He is a graduate of St. Bonaventure University and holds an MBA from the University of Rochester.
 

CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

Funding arrangements with Cagan McAfee Capital Partners, LLC and related parties

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          On December 1, 2003, Minrad Inc. entered into a funding agreement with Cagan McAfee Capital Partners, LLC ("Cagan McAfee") under which Cagan McAfee agreed to assist Minrad Inc. in obtaining up to $7.7 million in equity funding. Under the terms of the funding agreement, Minrad Inc. agreed to compensate Cagan McAfee through:

  · payment of a management fee equal to 2% of the proceeds raised by Minrad Inc. during the term of the agreement in any equity funding transaction;
  · payment of an advisory fee equal to 8% of the proceeds of any equity funding transaction lead managed directly by Cagan McAfee or International Capital Advisory, Inc., a Canadian corporation ("International Capital") or by a third party engaged by the them;
  · grant of investment warrants, exercisable for a period of seven years, to purchase a number of shares of Minrad Inc. common stock equal to 10% of the number of shares sold in any equity funding lead managed directly by the Advisors or by a third party engaged by the Advisors, with the warrants to be exercisable at the same price as the shares were sold in the equity funding; and
  · grant of incentive warrants, exercisable for a period of two years, to purchase up to 5,000,000 shares of Minrad Inc. common stock at an exercise price of $0.001 per share.

          Between December 1, 2003 and July 15, 2004, Minrad Inc. sold an aggregate of 3,201,084 shares of common stock at $1.25 per share in private placements contemplated by the funding agreement. The sales yielded gross proceeds of $4,001,355. Under the terms of the funding agreement, Minrad Inc. paid the Advisors and related parties $400,135 in fees in connection with the private placements.

          On May 20 and 21, 2004, International Capital., Laird Cagan ("Cagan"), and Eric McAfee ("McAfee") and certain related parties acquired beneficial ownership of an aggregate of 3,483,750 shares, or approximately 69% of our then-outstanding common stock. Also on May 20 and 21, 2004, John Liviakis and Liviakis Financial Communications, Inc. acquired beneficial ownership of an aggregate of 800,000 shares, or approximately 16% of our then-outstanding common stock, of which 400,000 shares were issued to Liviakis Financial Communications, Inc. as consideration for public relations services to be provided to us under a contract expiring on the anniversary of our acquisition of, or merger with, an operating company. In connection with the transaction, on May 20, 2005 Wilhelm Liesner ("Liesner"), Markus Liesner, and Kae Velmeden sold an aggregate of 1,500,000 shares of our common stock to the purchasers, including 450,000 shares to International Capital, 241,875 shares to Cagan, and 241,875 shares to McAfee. At the same time, Liesner assigned our $75,000 promissory note payable to him (the "Liesner Note") to International Capital, Cagan, and McAfee. The aggregate sale price for the 1,500,000 shares and the Liesner Note was $10,000.

          On May 21, 2004, we sold 100,000 shares of common stock to the Tobin Family Trust for $4,000, 37,500 shares of common stock to Cagan for $1,500, 37,500 shares of common stock to McAfee, and an aggregate of 20,000 shares to other parties for $800. At the same time, we received and retired the Liesner Note in consideration for which we issued 745,000 shares of common stock to the Tobin Family Trust, 565,000 common shares to Cagan, and 565,000 shares to McAfee.

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          Also on May 21, 2004, we entered into an advisory agreement with the Cagan McAfee and Morrie Tobin (collectively, the "Advisors"), in consideration of which we issued 250,000 shares of common stock to Cagan McAfee and 250,000 shares of common stock to Morrie Tobin. Under the adviory agreement the Advisors agreed to provide us with advisory services in connection with structuring and negotiating a potential acquisition transaction involving our company and a target operating company to be identified by the Advisors with which we would be merged, or which we would acquire, with the surviving entity to continue our business.

          The Advisors identified Minrad Inc. as a potential acquisition candidate and, on July 15, 2004, we entered into the acquisition agreement described above.

          On September 15, 2004, we entered into an agreement with Chadbourn Securities, Inc. ("Chadbourn"), an affiliate of Cagan McAfee, under which Chadbourn agreed to act as our placement agent for a private placement of our common stock. Under the agreement with Chadbourn, we agreed to pay Chadbourn cash fees equal to 10% of the gross proceeds of a private placement of our common stock and warrants to purchase a number of shares of our common stock equal to 10% of the number shares sold in the offering, with the warrants to be exercisable at the price of the shares sold in the offering. Under an understanding between Minrad Inc. and Cagan McAfee, the payments to Chadbourn correspondingly reduced Minrad Inc.'s payment obligations under its funding agreement with Cagan McAfee. Between September 16, 2004 and December 15, 2004, we sold an aggregate of 585,257 shares of our common stock at $1.75 per share in private placements. The sales raised gross proceeds of $1,024,201, and we paid Chadbourn and its affiliates $102,420 in fees. We loaned a portion of the net proceeds of the private placements to Minrad Inc. pursuant to a 6% secured grid note.

          On December 15, 2004, as compensation for its services under the funding agreement, we entered into a warrant agreement with Cagan McAfee and Chadbourn, under which we issued warrants to ten persons to purchase an aggregate of 320,108 shares at $1.25 per share and to three other persons to purchase an aggregate of 58,526 shares at $1.75 per share. The total number of shares purchasable under the warrants equaled 10% of the amount of shares sold in Minrad Inc.'s and our private placements described above. The warrants expire on December 15, 2011 and contain cashless net exercise provisions. On February 7, 2005, we completed private sales of an additional 321,714 shares of our common stock at $1.75 per share, and we paid commissions of $56,300 and issued warrants to purchase an additional 32,171 shares to Chadbourn and its affiliates.

          On February 8, 2005, we entered into agreements with Cagan and the Tobin Family Trust to sell to them for an aggregate of $2.5 million (1) convertible promissory notes in the aggregate principal amount of $2.5 million, and (2) warrants to purchase, at any time prior to January 30, 2007, 375,000 shares of our common stock at $1.75 per share. The convertible promissory notes were subsequently amended on May 11, 2005 and May 25, 2005. As amended, the convertible promissory notes mature on October 7, 2005, but are subject to pre-payment at our option or at the option of the holders if we have aggregate outstanding indebtedness (on a consolidated basis) to one or more banks in excess of $5 million ("Bank Borrowing"). If Bank Borrowing in excess of $5 million occurs, then commencing on that date the holders will have the right to convert all or any portion of the outstanding notes into common stock at $1.75 per share, and commencing 7 days thereafter we will have the option to prepay the notes and the holders will have the option to accelerate the maturity of the notes. The convertible promissory notes mature on October 7, 2005, bear interest at the rate of 6% per annum payable at maturity, and are secured by a second mortgage on our production facility in Bethlehem, Pennsylvania, and a second security interest in all of our personal property located at the site.

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          As indicated above, Minrad Inc. entered into a funding agreement with Cagan McAfee dated December 1, 2003 under which Cagan McAfee agreed that it and its affiliates or assigns would assist Minrad Inc. in the placement of up to $7.7 million of equity funding. The funding agreement provided, among other things, the Cagan McAfee or its affiliates and assigns, including Chadbourn, would earn the right to acquire up to 5 million shares of Minrad Inc.'s common stock at a nominal price if they assisted Minrad Inc. in obtaining $7.7 million of equity funding. When Minrad Inc. was acquired by us in a reverse merger with our subsidiary, the parties agreed that this right would be converted into a right by Cagan McAfee and its affiliates and related parties, to retain up to 5 million shares of our common stock acquired by them prior to the reverse merger, subject to our right to purchase a proportionate number of our shares from them at a nominal price if they failed to obtain an aggregate of $7.7 million of equity funding for Minrad Inc. and us under the terms of the funding agreement.

          The sale of the convertible promissory notes and warrants was deemed by the parties to the funding agreement to constitute equity funding under the agreement and, as a result of the sale, the total amount of equity funding under the funding agreement exceeded $7.7 million. Accordingly, Chadbourn was credited with completing the final $1,659,179 of the $7.7 million equity funding under the funding agreement, and our right to purchase up to 1,077,388 of our shares from Cagan McAfee and its affiliates and related parties at a nominal price was extinguished. Other than the termination of this right to buy up to 1,077,388 of our shares from Cagan McAfee and its affiliates and related parties at a nominal price, no underwriting discounts or commissions were paid in connection with the sale of the convertible promissory notes and related warrants.

          During the period from June 10, 2005 through July 1, 2005, we sold 11,260 shares of Series A convertible preferred stock and warrants to purchase 2,815,000 shares of common stock for an aggregate price of $11.26 million. Each share of Series A preferred stock is convertible into 500 shares of common stock, and the related warrants are exercisable for a period of three years at $3.85 per share of common stock. The sales were made to 19 persons and entities, with substantially all of the shares being purchased by institutional investors and their related parties. The sales of Series A convertible preferred stock and warrants were made pursuant to an exemption from registration under Section 4(2) of the Securities Act and Rule 506 of Regulation D under the Securities Act in an an offering made exclusively to accredited investors, as that term is defined in Rule 501 of Regulation D. In connection with the sales, we paid to placement agent fees and/or finders aggregate cash fees of $1,101,000 and warrants exercisable for a period of 7 years to purchase 563,000 shares of common stock at $2.00 per share. Of those fees and warrants, we paid $370,000 and warrants to purchase 9,638 shares to Chadbourn, warrants to purchase 183,112 shares to Cagan, and $246,500 and warrants to purchase 192,750 shares to International Capital.

          The offers and sales of common stock by Minrad Inc. and us, of the convertible promissory notes and related warrants by us, and of Series A convertible preferred stock and related warrants by us made in the private placements discussed above, and the issuance of warrants to Cagan McAfee, Chadbourn, and their affiliates as compensation for their services under the funding agreement, each discussed above, were made solely to "accredited investors," as that term is defined in Rule 501 of Regulation D under the Securities Act, pursuant to an exemption from registration under Section 4(2) of the Securities Act and Rule 506 under the Securities Act.

 

Financing Arrangements with Spencer Trask Specialty Group LLC

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          During the fiscal year ended September 30, 2004, Minrad Inc. engaged in the following transactions with Spencer Trask Specialty Group LLC, an entity that beneficially owned approximately 22.5% of Minrad International's outstanding common stock immediately after the merger with Minrad Inc.

  
  •   
Minrad Inc. repaid $457,482 under a $750,000 convertible promissory note held by Spencer Trask that was due in March 2004 and accrued interest at the rate of 8%. Spencer Trask sold the unpaid balance of $292,518 on the note to a third party which exchanged the note with Minrad Inc. for 390,024 shares of common stock at a rate of $.75 per share.
 
  
  •   
Minrad Inc. repaid the outstanding principal and accrued interest on a $75,000 convertible promissory note held by Spencer Trask which accrued interest at the rate of 10% and was past due.
 
  
  •   
Minrad Inc. repaid the outstanding principal and accrued interest on a $250,000 convertible promissory note held by Spencer Trask, which accrued interest at the rate of 10% and was past due.
 
  
  •   
Minrad Inc. repaid the outstanding principal and accrued interest on a $500,000 convertible promissory note held by Spencer Trask, which accrued interest at the rate of 10% and was past due.

          Two of Minrad Inc.'s directors, who became directors of Minrad International at the time of the merger, are Donald Farley, who is a principal and the Chief Executive Officer of Spencer Trask, and David DiGiacinto, who is a Senior Managing Director of Spencer Trask.

          Also during the fiscal year ended September 30, 2004, Minrad Inc. converted a $100,000 convertible promissory note and $10,000 of accrued interest held by Donald Farley into 146,667 shares of its common stock at a rate of $.75 per share. The note was past due and had accrued interest at the rate of 10%.

Financial Arrangements with New England Capital Partners, LLC

          During our fiscal year ended September 30, 2004, Minrad Inc. engaged in the following transactions with New England Capital Partners, LLC, an entity that beneficially owned approximately 14% of Minrad International's outstanding common stock immediately after the merger with Minrad Inc..

  
  •   
Minrad Inc. repaid the principal and accrued interest on a $75,000 demand promissory note held by New England Partners. The note accrued interest at the rate of 8%.
  
  •   
Minrad Inc. exchanged 1,076,814 shares of its common stock, at a rate of $.75 per share, for a $750,000 convertible promissory note, and $57,611 of accrued interest on the note, held by New England Partners. The note had accrued interest at a rate of 8%.

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  •   
Minrad Inc. exchanged 911,285 shares of its common stock for a $800,000 demand convertible promissory note and $83,463 of accrued interest on the note, held by New England Partners. The principal was exchanged at the rate of $1.00 per share and the interest was exchanged at a rate of $.75 per share. The note had accrued interest at the rate of 8%.

          John Rousseau, one of Minrad Inc.'s directors who became one of Minrad International's directors at the time of the merger, is a managing general partner of New England Partners.

Obligations payable to BioSight Inc. and BioVision Inc.

          For more than three years, Minrad Inc. has had an outstanding payable of approximately $88,600 to BioVision Inc., a company in which William Burns is Chairman of the Board and a shareholder. We have agreed to cause Minrad Inc. to pay off the amount owed in four monthly installments of $22,150 each beginning at the end of April 2005. Mr. Burns has been the Chairman, President and Chief Executive officer Minrad Inc. since its formation, and he has been the Chairman, President and Chief Executive Officer of Minrad International since the merger with Minrad Inc.

          For more than five years, Minrad Inc. has had an outstanding payable of approximately $250,000 to BioSight Inc., a company in which William Burns is the Chairman of the Board and a shareholder. Under a tax dispute between BioSight and the IRS, the IRS imposed a tax lien on the payable from Minrad Inc. to BioSight. Between October 1, 2003 and February 2005, Minrad Inc. paid an aggregate of $88,775 to the IRS to satisfy the tax lien. We have agreed to cause Minrad Inc. to pay BioSight an additional $159,335.50 in 14 equal monthly installments of $11,395.25 each, beginning at the end of April 2005, as payment for the remaining payable.

 

STOCK OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

          The table below sets forth information with respect to beneficial ownership of our common stock as of July 1, 2005, by: (1) each person or "group," as that term is used in Section 13(d)(3) of the Securities Exchange Act of 1934, known to us to have owned beneficially more than 5% of our outstanding common stock; (2) each of our directors and executive officers; and (3) all of our directors and executive officers as a group.

          We determined beneficial ownership in accordance with the rules of the SEC. Unless otherwise indicated below, the persons named in the table below have sole voting and investment power with respect to all shares shown as beneficially owned by them. Shares of common stock subject to any warrants or options that were exercisable on or within 60 days of July 1, are deemed outstanding for the purpose of computing the percentage ownership of the person holding the warrants or options, but are not treated as outstanding for the purpose of computing the percentage ownership of any other person. The beneficial ownership percentages in the table below of any person are based on 28,430,000 shares of our common stock outstanding, plus, in each case, any shares of common stock subject to warrants or options owned by that person that were exercisable on or within 60 days of July 1, 2005.

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Name of Beneficial Owner

Number of Shares

Percent

Beneficial owners of more than 5% of our common stock(1)
Spencer Trask Specialty Group LLC (2) 6,581,742   22.2%
New England Partners Capital LLC (3) 3,980,392   13.8%
Rubicon Master Fund (4) 3,000,000 9.5%
Kevin Kimberlin Partners L.P. (5) 2,950,000   9.4%
Laird Q. Cagan (6) 2,215,736   7.6%
Harris Toibb (7) 2,193,750   7.2%
Crestview Capital LLC (8)   1,575,000     5.2%
           
Directors and executive officers **  
William H. Burns, Jr. (9) 1,858,001   6.4%
David DiGiacinto (10) 25,000   *
David Donaldson (11) 25,000   *
Donald F. Farley (12) 298,739   1.7%
Duane Hopper (13) 109,675   *
Robert Lifeso (14) 637,881   2.2%
John Rousseau (15) 25,000   *
William Bednarski -0-   -0-
John McNeirney (16) 172,248   *
Kirk Kamsler (17) 100,306   *
Richard Tamulski (18) 67,500   *
           
All directors and executive officers as a group (11 persons)(19)   3,322,350     11.3%

_____________________
* Beneficial ownership of less than 1%.
** Address: 847 Main Street, Buffalo, New York 14203

1.   Excludes William H. Burns, Jr., our Chairman, President and Chief Executive Officer, who beneficially owned more than 5% of our common stock. Information with respect to Mr. Burns' beneficial ownership of our common stock is included below under the caption "Directors and executive officers."
 
2.   Includes (i) 5,314,847 shares held by Spencer Trask Specialty Group LLC and various affiliates, and (ii) 1,266,895 shares that Spencer Trask Specialty Group and various affiliates have the right to acquire pursuant to warrants that were exercisable on or within 60 days of July 1, 2005. Does not include the shares identified as being beneficially owned by Kevin Kimberlin Partners, LLP ("KKP") in footnote (4) below. Kevin Kimberlin, the General Partner of KKP, is the controlling stockholder of Spencer Trask & Co., an affiliate of Spencer Trask Specialty Group. Address: 535 Madison Avenue, New York, New York 10022.
 
3.   Includes (i) 3,505,392 shares held by New England Partners Capital, LLC ("NEP") and (ii) 475,000 shares that NEP has the right to acquire pursuant to warrants that were exercisable on or

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within 60 days of July 1, 2005. Address: One Boston Place, Suite 3630, Boston, Massachusetts 02108
 

4.   Includes (i) 4,000 shares of Series A Preferred that are convertible into 2,000,000 shares of common stock, (ii) 1,000,000 shares of common stock that Rubicon Master Fund has the right to acquire pursuant to warrants that are exercisable within 60 days of June 21, 2005. Pursuant to Investment Agreements, each of Rubicon Fund Management Ltd. and Rubicon Fund Management LLP share all investment and voting power with respect to the securities held by Rubicon Master Fund. By reason of the provisions of Rule 13d-3 under the Securities Exchange Act of 1934, each of Rubicon Fund Management, Ltd, Rubicon Fund Management LLP, Paul Anthony Brewer, Jeffrey Eugene Brummette, William Francis Callanan, Vilas Gadkari, Robert Michael Greenshields and Horace Joseph Leitch III may be deemed to own beneficially the shares of common stock held beneficially by Rubicon Master Fund; each of them disclaims beneficial ownership of those shares. Address of Rubicon Master Fund: P.O. Box 309, Ugland House, George Town, Cayman Islands.
 
5.   Includes warrants to purchase 2,950,000 shares that KKP has the right to acquire pursuant to warrants that are exercisable on or within 60 days of July 1, 2005. Mr. Kimberlin is the General Partner of KKP and the controlling stockholder of Spencer Trask & Co., an affiliate of Spencer Trask Specialty Group.
 
6.   Includes (i) 1,380,733 shares held directly by Mr. Cagan, (ii) 249,100 shares held by Cagan McAfee Capital Partners, LLC, an entity in which Mr. Cagan owns a 50% interest and shares voting and dispositive power, (iii) 472,396 shares that Mr. Cagan has the right to acquire pursuant to warrants that were exercisable on or within 60 days of July 1, 2005, (iv) 168 shares of Series A preferred that are convertible into 84,000 shares of common stock, and (v) an aggregate of 29,507 shares that affiliates of Mr. Cagan, Chadbourn Securities and Cagan Capital - Private Equity Fund II, LLC, have the right to acquire pursuant to warrants that were exercisable on or within 60 days of July 1, 2005. Address: c/o Cagan McAfee Capital Partners, LLC, 10600 N. De Anza Blvd., Suite 250, Cupertino, California 95014.
 
7.   Includes: (i) 2,525 shares of Series A preferred that are convertible into 1,262,500 shares of common stock, which are held by Toibb Investment LLC, (ii) 706,250 shares of common stock that Toibb Investment LLC has the right to acquire pursuant to warrants that are exercisable within 60 days of July 1, 2005, (iii) 300 shares of Series A preferred that are convertible into 150,000 shares of common stock, which are held by HLTGT LLC, and (iv) 75,000 shares of common stock that HLTGT LLC has the right to acquire pursuant to the exercise of warrants that are exercisable within 60 days of July 1, 2005.  Harris Toibb has sole voting and investment power with respect to all of our shares that held by Toibb Investment LLC and HLTGT LLC.
 
8.   Includes (i) 1,000,000 shares of common stock that are issuable upon conversion of Series A Preferred, and (ii) 575,000 shares of common stock that Crestview Capital LLC has the right to acquire pursuant to warrants that are exercisable within 60 days of July 1, 2005.
 
9. Includes (i) 1,410,000 shares held by Mr. Burns and (ii) 448,001 shares that Mr. Burns has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005.

 

10.   Includes 25,000 shares that Mr. DiGiacinto has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005. Mr. DiGiacinto is a Senior Managing Director of Spencer Trask Specialty Group, LLC. Does not include, and Mr. DiGiacinto disclaims beneficial ownership of, the 6,581,742 shares identified as being beneficially owned by Spencer Trask Specialty Group in footnote (2) above.

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11.   Includes 25,000 shares that Mr. Donaldson has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005.
 
12.   Includes (i) 246,667 shares held by Mr. Farley, (ii) 22,072 shares that Mr. Farley has the right to acquire pursuant to outstanding warrants that were exercisable on or within 60 days after July 1, 2005, and (iii) 30,000 shares that Mr. Farley has the right to acquire pursuant to outstanding options that were exercisable on or within 60 days after July 1, 2005. Mr. Farley is a principal and the Chief Executive Officer of Spencer Trask Specialty Group. Does not include, and Mr. Farley disclaims beneficial ownership of, the 6,581,742 shares identified as being beneficially owned by Spencer Trask Specialty Group in footnote (2) above.
 
13.   Includes (i) 84,675 shares held by Mr. Hopper and (ii) 25,000 shares has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005.
 
14.   Includes (i) 607,881 shares held by Dr. Lifeso and (ii) 30,000 shares that Dr. Lifeso has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005.
 
15. Includes 25,000 shares that Mr. Rousseau has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005. Does not include the 3,980,392 shares described in footnote (3) above, with respect to which Mr. Rousseau, as a Managing General Partner of NEP, exercises voting and investment power.
 
16.   Includes (i) 78,248 shares held by Mr. McNeirney and (ii) 97,000 shares that Mr. McNeirney has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005.
 
17. Includes (i) 4,056 shares held by Mr. Kamsler and (ii) 96,250 shares that Mr. Kamsler has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005.

 

18.   Includes 67,500 shares that Mr. Tamulski has the right to acquire pursuant to options that were exercisable on or within 60 days after July 1, 2005.
 
19.   Includes options to purchase 868,751 shares that were exercisable by members of the group on or within 60 days after July 1, 2005.
 

 

MARKET FOR OUR CAPITAL STOCK

Market Information

          Our common stock is quoted under the symbol, "MNRD.OB" on the OTC Bulletin Board, a service maintained by the National Association of Securities Dealers, Inc. Trading in the common stock in the over-the-counter market has been limited and sporadic and the quotations set forth below are not necessarily indicative of actual market conditions. All prices prior to the quarter ended September 30, 2004 reflect activity in our common stock prior to the announcement of our agreement to acquire Minrad Inc. Further, all prices reflect inter-dealer prices without retail mark-up, mark-down, or commission and

-67-

may not necessarily reflect actual transactions. The high and low sales prices for the periods presented have been adjusted to reflect stock splits:

     
     
     
     
 

High

Low

2003    
March 31, 2003

*

*

June 30, 2003

.04

.01

September 30, 2003

.06

.04

December 31, 2003

.06

.05

     
2004    
March 31, 2004

.11

.06

June 30, 2004

.11

.11

September 30, 2004

10.05

.11

 December 31, 2004

4.25

2.50

     
2005    
March 31, 2005

7.00

3.00

June 30, 2005

4.40

2.00

 
*no available quoted prices during these periods

Holders

          As of July 1, 2005, there were approximately 544 stockholders of record of our common stock.

Dividends

          We have not paid any dividends since inception and do not anticipate paying any dividends in the foreseeable future. Additionally, one of our loan agreements prohibits us from paying or declaring a dividend until the loan is paid in full. We currently intend to retain all available funds and any future earnings of our business for use in the operation of our business. The declaration, payment and amount of future dividends, if any, will depend upon our future earnings, results of operations, financial position and capital requirements, among other factors, and will be at the sole discretion of our Board of Directors.

Securities authorized for issuance under equity compensation plan

          As of December 31, 2004, our only equity compensation plan was our 2004 Stock Option Plan, which was previously approved by our stockholders. The following table provides information about the plan as of that date.

 

Equity Compensation Plan Information

-68-

           
 

(a)

 

(b)

 

(c)

 

Number of securities to be issued upon exercise of outstanding options, warrants and rights

 

Weighted-average exercise price of outstanding options, warrants and rights

 

Number of Securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a))

           
Plan Category          
Equity compensation plans approved by security
     holders ..............................................................

2,360,917

 

$1.50

 

4,794,583

           
           

 

(1) Reflects shares issuable upon exercise of options issued and issuable under the Company's 2004 Stock Option Plan.

Purchase of shares

          During the six-month period ended June 30, 2005, we have not purchased any of our shares.

DESCRIPTION OF CAPITAL STOCK

          We are authorized to issue 100,000,000 shares of common stock, par value $.01 per share and 5,000,000 shares of preferred stock, par value $.25 per share. As of July 1, 2005 we have approximately 28,430,000 shares of our common stock issued and outstanding and 11,260 shares of our Series A convertible preferred stock outstanding.

Warrants

          As of July 1, 2005, there are outstanding warrants exercisable to purchase our common stock as follows:

  • warrants to purchase 450,000 shares of common stock at $.075 per share;

  • warrants to purchase 2,975,000 shares of common stock at $1.00 per share;

  • warrants to purchase 1,339,587 shares of common stock at $1.15 per share;

  • warrants to purchase 320,108 shares of common stock at $1.25 per share;

  • -69-

  • warrants to purchase 465,697 shares of common stock at $1.75 per share;

  • warrants to purchase 563,000 shares at $2.00 per share; and

  • warrants to purchase 2,815,000 shares at $3.85 per share.

  •           The warrants are subject to anti-dilution adjustments, are exercisable for periods ranging from 3 to 7 years, and in certain cases contain cashless exercise provisions.

    Options

              There are outstanding options under our 2004 Employee Stock Option Plan for participants to purchase up to 2,644,688 shares of common stock at an average exercise price of $1.51 per share and of which 996,425 are fully vested.

    Convertible Promissory Notes

              There are outstanding $2.5 million face amount of convertible promissory notes that mature on October 7, 2005. The convertible promissory notes bear interest at the rate of 6% per annum, payable at maturity. If, at any time while the convertible notes are outstanding, we have $5 million of bank borrowing outstanding, then the outstanding principal and interest of the convertible promissory notes will become convertible into common stock at $1.75 per share (subject to adjustments).

    Preferred Stock

              Our Articles of Incorporation permit our Board of Directors to fix the rights, preferences and privileges of, and issue up to 5,000,000 shares of, preferred stock with voting, conversion, dividend and other rights and preferences that could adversely affect the voting power or other rights of our shareholders. The issuance of preferred stock or rights to purchase preferred stock could have the effect of delaying or preventing a change in control of the Company. In addition, the possible issuance of additional preferred stock could discourage a proxy contest, make more difficult acquisition of a substantial block of Company's common stock or limit the price that investors might be willing to pay for shares of the Company's common stock.

              Effective June 8, 2005, we amended our Certificate of Incorporation by filing a Certificate of Designations with the Secretary of State of the State of Delaware. The Certificate of Designations authorizes us to issue 15,000 shares of Series A convertible preferred stock, par value $0.25 per share. During the period from June 10 through July 1, 2005, we issued a total of 11,260 shares of Series A convertible preferred stock. The rights, preferences, and limitations of the Series A convertible preferred stock are summarized as follows:

    • Stated Value: $1,000 per share (subject to anti-dilution and other adjustments)

    • Dividends: 6% per annum, compounded continuously, payable quarterly in cash, or at the option of the company and subject to certain limitations, in shares of common stock. In addition, the Series A preferred participates with the common stock in any dividends payable to the holders of the common stock as if the Series A preferred had been converted into common stock. Without the express

      -70-

      written consent of the holders of Series A preferred, Minrad may not declare or pay any cash dividend or distribution on its common stock.

    • Convertible: at any time at the election of the holder into common stock at a rate of 500 shares of common stock per share(subject to anti-dilution and other adjustments); subject to certain conditions, at the election of Minrad if the company's common stock maintains a trading price of $5.00 or more for 20 consecutive trading days; and subject to mandatory conversion after 4 years, unless redeemed by the company at that time.

    • Redemption: redeemable at Stated Value at the option of the holder if Minrad fails to maintain registration under the Securities Act of the resale of conversion shares of common stock as required, or in the event of a change of control; or at the option of Minrad in lieu of mandatory conversion after 4 years.

    • Preferences: shares are preferred over the common stock as to dividends, distributions and payments upon liquidation, dissolution or winding up of the company.

    • Voting: the Series A preferred has no voting rights except as required by law or in limited circumstances as described in the Certificate of Designations.

    • Other rights: Minrad may not engage in any recapitalization, reclassification, consolidation, merger, or sale of all or substantially all of its assets to another person if Minrad will not be the surviving entity unless the acquiring entity agrees in a manner satisfactory to the holders of a majority of the Series A preferred to exchange for the Series A Preferred securities of the other entity that are substantially similar in form and substance to the Series A preferred.

              The foregoing is only a summary of certain material terms of the Series A preferred. For a complete description of the rights and preferences of the Series A preferred, reference is made to the Certificate of Designations.

    Common Stock

            The following statement is a brief summary of certain provisions relating to our common stock:

            Dividends. The holders of common stock are entitled to receive, ratably, dividends when, as and if declared by the Board of Directors out of funds legally available therefore.

            Liquidation Preference. In the event of our liquidation, dissolution or winding up, the holders of common stock are entitled, subject to the rights of holders of our preferred stock, if any, to share ratably in all assets remaining available for distribution to them after payment of liabilities and after provision is made for each class of stock, if any, having preference over the common stock.

            Conversion. The holders of common stock have no conversion rights and they are not subject to further calls or assessments by us.

    -71-

            Preemption. The holders of common stock have no preemptive rights and they are not subject to further calls or assessments by us.

            Voting Rights. The holders of common stock are entitled to one vote for each share held of record on all matters on which the holders of common stock are entitled to vote.

            Redemption. There are no redemption or sinking fund provisions applicable to the common stock. The outstanding shares of common stock are fully paid and nonassessable.

    LEGAL MATTERS

            Hodgson Russ LLP, One M&T Plaza, Suite 2000, Buffalo, New York, will opine on the validity of the common stock offered in this prospectus.

    EXPERTS

            Our financial statements as of December 31, 2004, September 30, 2004 and 2003, for the three months ended December 31, 2004, and for each of the two years in the period ended September 30, 2004 have been included in reliance upon the report of Freed Maxick & Battaglia, CPAs, PC, and upon the authority of said firm as experts in accounting and auditing.

    CHANGE OF ACCOUNTANTS

            On December 16, 2004, our Board of Directors determined that upon completion of our merger with Minrad, we would change our certifying accountant and auditor to Minrad's auditor, Freed Maxick & Battaglia, CPAs, PC ("Freed") of Buffalo, New York.  On December 20, 2004, we orally notified and dismissed our prior auditor, Clancy and Co., P.L.L.C. ("Clancy and Co.") of Phoenix, Arizona. Minrad previously engaged Freed on January 21, 2004 to audit its financial statements for the fiscal years ended September 30, 2002, 2003, and 2004. 

            The reports of Clancy and Co. on our financial statements for each of the fiscal years ended March 31, 2003 and 2004 did not contain any adverse opinion or disclaimer of opinion and were not modified as to uncertainty, audit scope or accounting principles, other than an explanatory paragraph regarding the substantial doubt about our ability to continue as a going concern.

            Neither we nor anyone on our behalf consulted with Freed during our two most recent fiscal years ended March 31, 2003 or 2004 or during the subsequent interim period through December 16, 2004 preceding the dismissal of Clancy and Co., with respect to any of the matters set forth in Item 304(a)(2)(i) or (ii) of Regulation S-B.

            None of the reportable events listed in Item 304(a)(1)(iv)(B) of Regulation S-B occurred with respect to our two most recent fiscal years ended March 31, 2003 and 2004 or the subsequent interim period through December 16, 2004 preceding the dismissal of Clancy and Co.

    -72-

            At no time during our two most recent fiscal years ended March 31, 2003 and 2004, or during the subsequent interim period through December 16, 2004, were there any disagreements with Clancy and Co. on any matter of accounting principles or practices, financial statement disclosure or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of Clancy and Co. would have caused Clancy and Co. to make reference to the subject matter of the disagreements in its reports on the our financial statements.

            We provided Clancy and Co. with a copy of our Form 8-K/A announcing our change in certifying accountant prior to filing it with the SEC on January 19, 2004 and requested a response thereto from Clancy and Co.  A copy of the letter from Clancy and Co. stating its agreement with the statements in Item 4.01 thereof was filed as Exhibit 16.1 to that Form 8-K/A.

     

    -73-

     

    INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

    Table of Contents

    INDEX TO MINRAD INTERNATIONAL INC. CONSOLIDATED FINANCIAL
    STATEMENTS

    Independent Auditors Report F-2
    Consolidated Balance Sheets as of December 31, 2004 and September 30, 2004 and 2003 F-3
    Consolidated Statements of Operations for three months ended December 31, 2004  
      and years ended September 30, 2004 and 2003 F-4
    Consolidated Statements of Changes in the Stockholders' Deficit for the three months ended December 31,2004  
      and the years ended September 30, 2004 and 2003 F-5
    Consolidated Statements of Cash Flows for the three months ended December 31, 2004  
      and the years ended September 30, 2004 and 2003 F-6
    Notes to Consolidated Financial Statements F-7
       
    Unaudited Interim Financial Statements:  
    Consolidated Balance Sheets as of March 31, 2005 (Unaudited) and  
      December 31, 2004 (Audited) F-33
    Consolidated Statements of Operations for three months ended  
      March 31, 2005 and 2004 (Unaudited) F-34
    Consolidated Statements of Changes in the Stockholders' Deficit for the Quarter ended  
      March 31, 2005 F-35
    Consolidated Statements of Changes in the Stockholders' Deficit for the Quarter ended  
      March 31, 2004 F-36
    Consolidated Statements of Cash Flows for the three months ended  
      March 31, 2005 and 2004 (Unaudited) F-37
    Notes to Consolidated Financial Statements (Unaudited) F-38

    F-1

    REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

     

    Board of Directors
    Minrad International, Inc. and Subsidiary

     

            We have audited the accompanying consolidated balance sheets of Minrad International, Inc. and Subsidiary (Minrad) as of December 31, 2004 and September 30, 2004 and 2003, and the related consolidated statements of operations, changes in stockholders' deficit, and cash flows for the three-month period ended December 31, 2004 and years ended September 30, 2004 and 2003. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits.

            We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. Minrad is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. Our audits included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of Minrad's internal control over financial reporting. Accordingly, we express no such opinion. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

            In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of Minrad as of December 31, 2004 and September 30, 2004 and 2003, and the results of its operations and its cash flows for the three-month period ended December 31, 2004 and years ended September 30, 2004 and 2003 in conformity with accounting principles generally accepted in the United States of America.

     

    Freed Maxick & Battaglia, CPAs, PC

    Buffalo, New York
    March 23, 2005

    See accompanying notes.

    F-2

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    CONSOLIDATED BALANCE SHEETS

     

     

    December 31,

    September 30,

    ASSETS

    2004

    2004

    2003

                 

    Current assets:

               

    Cash

    $

    2,930

      $

    587

      $

    750

     

    Accounts receivable, net

    606,229

     

    529,759

     

    819,446

     

    Inventories, net

    1,069,565

     

    1,108,692

     

    1,328,935

     

    Prepaid expenses

    472,049

     

    131,181

     

    45,765

     

    Total current assets

    2,150,773

     

    1,770,219

     

    2,194,896

     
                 
    Property and equipment:            

    Machinery and equipment

    721,501

     

    721,501

     

    716,973

     

    Computers

    128,949

     

    128,949

     

    108,254

     

    Furniture and fixtures

    22,641

     

    22,641

     

    10,670

     

    Construction in progress

    300,241

     

    255,019

     

    -

     

     

    1,173,332

     

    1,128,110

     

    835,897

     

    Less accumulated depreciation

    674,126

     

    649,422

     

    509,811

     
     

    499,206

     

    478,688

     

    326,086

     
                 
    Other assets

    112,798

     

    101,127

     

    55,475

     
                 
      $

    2,762,777

      $

    2,350,034

      $

    2,576,457

     

    LIABILITIES AND STOCKHOLDERS' DEFICIT

    Current liabilities:

         

    Demand notes payable:

           

    Shareholders and affiliates

    $

    325,000

      $

    226,000

      $

    3,057,860

     

    Other

    1,146,125

     

    1,161,467

     

    1,111,398

     

    Accounts payable

    2,433,859

     

    1,895,090

     

    1,743,150

     

    Accrued expenses

    824,812

     

    644,142

     

    854,970

     

    Due to affiliates

    374,740

     

    403,905

     

    423,659

     

    Current portion of long-term debt,
        including default reclassifications

    1,022,309

     

    1,025,483

     

    1,272,362

     

    Total current liabilities

    6,126,845

     

    5,356,087

     

    8,463,399

     
                 

    Stockholders' deficit

    (3,364,068)

     

    (3,006,053)

     

    (5,886,942)

     
                 
      $

    2,762,777

      $ 2,350,034   $

    2,576,457

     

    See accompanying notes.

    F-3

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    CONSOLIDATED STATEMENTS OF OPERATIONS

     

     

    Three Months

    Years Ended

     

    Ended December 31,

    September 30,

     

    2004

    2004

    2003

           
    Revenue $

    460,276

      $

    4,116,995

      $

    3,514,963

     
                 
    Cost of goods sold

    616,391

     

    3,150,479

     

    2,091,983

     
                 
    Gross profit (loss)

    (156,115)

     

    966,516

     

    1,422,980

     
                 
    Operating expenses:            

    Sales and marketing

    230,348

     

    736,266

     

    645,805

     

    Research and development

    308,670

     

    1,175,570

     

    1,269,842

     

    Finance and administrative

    486,970

     

    2,097,288

     

    1,550,259

     

    Total operating expenses

    1,025,988

     

    4,009,124

     

    3,465,906

     
                 
    Operating loss

    (1,182,103)

     

    (3,042,608)

     

    (2,042,926)

     
                 
    Non-operating expenses:            

    Interest expense:

               

    Shareholders and affiliates

    (130,715)

     

    (316,271)

     

    (503,268)

     

    Other

    (67,565)

     

    (473,172)

     

    (249,323)

     
    Debt conversion costs - shareholders

    -

     

    (713,000)

     

    -

     
     

    (198,280)

     

    (1,502,443)

     

    (752,591)

     
                 
    Net loss $

    (1,380,383)

      $

    (4,545,051)

      $

    (2,795,517)

     
                 
    Net loss per share, basic and diluted $

    (.06)

      $

    (.25)

     

    $

    (.21)

     
                 
    Weighted average common shares            

    outstanding, basic and diluted

    23,286,384

     

    17,974,769

     

    13,376,543

     

    See accompanying notes.

    F-4

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' DEFICIT
    For the Three Month Period Ended December 31, 2004 and
    the Years Ended September 30, 2004 and 2003

     

     

    Series A

    Convertible

    Preferred

    Stock

    Series B

    Convertible

    Preferred

    Stock

    Common

    Stock

    Additional

    Paid-in

    Accumulated

     

     

    Shares

    Amount

    Shares

    Amount

    Shares

    Amount

    Capital

    Deficit

    Total

    Balance at September 30, 2002

    607,251

     

    $4,858,008

     

    4,860,325

     

    $ 5,267,555

     

    8,687,909

     

    $ 86,879

     

    $ 1,656,644

     

    $ (15,435,511)

     

    $ (3,566,425)

     

    Issuance of series B preferred stock

    -

     

    -

     

    950,000

     

    475,000

     

    -

     

    -

     

    -

     

    -

     

    475,000

     

    Conversion of series A preferred

      stock to common stock

    (607,251)

     

    (4,858,008)

     

    -

     

    -

     

    607,251

     

    6,073

     

    4,851,935

     

    -

     

    -

     

    Conversion of series B preferred

      stock to common stock

    -

     

    -

     

    (4,860,325)

     

    (5,267,555)

     

    4,860,325

     

    48,603

     

    5,218,952

     

    -

     

    -

     

    Net loss

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    (2,795,517)

     

    (2,795,517)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Balance at September 30, 2003

    -

     

    -

     

    950,000

     

    475,000

     

    14,155,485

     

    141,555

     

    11,727,531

     

    (18,231,028)

     

    (5,886,942)

     

    Sale of common stock, net of

      offering costs

    -

     

    -

     

    -

     

    -

     

    3,211,084

     

    32,111

     

    3,517,936

     

    -

     

    3,550,047

     

    Conversion of debt to equity

    -

     

    -

     

    -

     

    -

     

    3,797,533

     

    37,975

     

    2,975,668

     

    -

     

    3,013,643

     

    Debt conversion costs

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    713,000

     

    -

     

    713,000

     

    Beneficial conversion feature of

      demand notes payable

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    123,000

     

    -

     

    123,000

     

    Conversion of series B preferred

      stock to common stock

    -

     

    -

     

    (950,000)

     

    (475,000)

     

    1,140,000

     

    11,400

     

    463,600

     

    -

     

    -

     

    Options exercised

    -

     

    -

     

    -

     

    -

     

    15,000

     

    150

     

    26,100

     

    -

     

    26,250

     

    Warrants converted to equity

    -

     

    -

     

    -

     

    -

     

    44,794

     

    448

     

    (448)

     

    -

     

    -

     

    Net loss

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    (4,545,051)

     

    (4,545,051)

     

     

     

     

    -

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Balance at September 30, 2004

    -

     

    -

     

    -

     

    -

     

    22,363,896

     

    223,639

     

    19,546,387

     

    (22,776,079)

     

    (3,006,053)

     

    Sale of common stock

    -

     

    -

     

    -

     

    -

     

    20,000

     

    200

     

    34,800

     

    -

     

    35,000

     

    Value of warrants issued with debt

      and for services

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    121,038

     

    -

     

    121,038

     

    Equity acquired in reverse

      acquisition

    -

     

    -

     

    -

     

    -

     

    5,635,257

     

    56,353

     

    809,977

     

    -

     

    866,330

     

    Net loss

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    -

     

    (1,380,383)

     

    (1,380,383)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Balance at December 31, 2004

    -

     

    $ -

     

    -

     

    $ -

     

    28,019,153

     

    $ 280,192

     

    $ 20,512,202

     

    $ (24,156,462)

     

    $ (3,364,068)

     

    See accompanying notes.

    F-5

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY
    CONSOLIDATED STATEMENTS OF CASH FLOWS

     

     

    Three Months

    Ended December

    Years Ended

    September 30,

     

    31, 2004

    2004

    2003

    Cash flows from operating activities:

     

     

     

     

     

     

    Net loss

    $

    (1,380,383)

     

    $

    (4,545,051)

     

    $

    (2,795,517)

     

    Adjustments to reconcile net loss to

     net cash used by operating activities:

     

     

     

     

     

     

      Depreciation

    24,704

     

    139,611

     

    146,330

     

      Increase (decrease) in allowance

        for doubtful accounts

    (103,000)

     

    65,000

     

    200,000

     

      Expenses satisfied with equity  instruments  

    121,038

     

    -

     

    -

     

      Debt conversion costs

    -

     

    713,000

     

    -

     

      Amortization of note discount

    -

     

    123,000

     

    205,218

     

      Decrease in inventory reserve

    -

     

    -

     

    (125,000)

     

      (Increase) decrease in assets:

     

     

     

     

     

     

       Accounts receivable

    26,530

     

    224,687

     

    (748,893)

     

       Inventory

    39,127

     

    220,243

     

    891,969

     

       Prepaid expenses

    (340,868)

     

    (85,416)

     

    8,700

     

      Increase (decrease) in liabilities:

     

     

     

     

     

     

       Accounts payable

    534,569

     

    168,432

     

    266,821

     

       Accrued expenses

    179,286

     

    (20,994)

     

    250,712

     

    Net cash used by operating activities

    (898,997)

     

    (2,997,488)

     

    (1,699,660)

     

     

     

     

     

     

     

     

    Cash flows from investing activities:

     

     

     

     

     

     

    Purchases of property and equipment

    (45,222)

     

    (241,233)

     

    (63,476)

     

    Patent costs

    (6,402)

     

    (57,805)

     

    -

     

    Proceeds from liquidation of investment 

    -

     

    -

     

    475,000

     

    Net cash provided (used) by investing activities

    (51,624)

     

    (299,038)

     

    411,524

     

     

     

     

     

     

     

     

    Cash flows from financing activities:

     

     

     

     

     

     

    Net decrease (increase) in restricted deposits 

    (5,269)

     

    12,153

     

    4,798

     

    Repayments from affiliates

    (29,165)

     

    (2,333)

     

    (131,677)

     

    Borrowings under demand notes

      payable

    971,500

     

    872,467

     

    2,950,000

     

    Repayments under demand notes

      payable

    (15,928)

     

    (915,342)

     

    (1,517,140)

     

    Principal payments on long-term debt

    (3,174)

     

    (246,879)

     

    (17,845)

     

    Issuance of common stock, net of

      offering costs

    35,000

     

    3,550,047

     

    -

     

    Proceeds from options exercised

    -

     

    26,250

     

    -

     

    Net cash provided by financing activities

    952,964

     

    3,296,363

     

    1,288,136

     

     

     

     

     

     

     

     

    Net change in cash

    2,343

     

    (163)

     

    -

     

     

     

     

     

     

     

     

    Cash - beginning of period

    587

     

    750

     

    750

     

     

     

     

     

     

     

     

    Cash - end of period

    $

    2,930

     

    $

    587

     

    $

    750

     

    See accompanying notes.

    F-6

     

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 1. - NATURE OF BUSINESS

            Business Description - Minrad International, Inc. and Subsidiary (the Company) is an acute care company with two product lines: (1) real-time image guidance and (2) anesthesia and analgesia. The Company's products are sold throughout the world, primarily in North America, Europe and Asia. The Company's real-time image guidance products are used in the hospital acute care and operating room market. The Company is in the process of redesigning these products, resulting in minimal revenue during the period ended December 31, 2004 and the years ended September 30, 2004 and 2003. The anesthesia and analgesia business is engaged currently in the manufacture and sale of generic inhalation anesthetics that are primarily used for human and veterinary surgical interventions. Approximately 98% of the Company' sales revenue for the three-month period ended December 31, 2004 was generated from the sale of inhalation anesthetics (99% and 94% respectively for fiscal 2004 and 2003).

            Merger - On July 15, 2004, Minrad Inc. entered into a Merger Agreement and Plan of Exchange (the Agreement) with Technology Acquisition Corporation (TAC), Technology Acquisition Subsidiary, Inc. (AS) and certain majority shareholders of TAC, which was consummated on December 16, 2004. TAC was a relatively inactive public company shell listed for quotation on the Over The Counter Bulletin Board. Under the terms of the Agreement, all outstanding stock of Minrad Inc. was exchanged for an 83% beneficial ownership of TAC stock. Minrad Inc. was merged with AS, with Minrad Inc. surviving and becoming a wholly owned subsidiary of TAC. TAC's name was changed immediately to Minrad International, Inc. As a result of the transaction, the former stockholders of Minrad Inc. own approximately 80% of the outstanding shares of TAC and have control of the Board of Directors. Accordingly, the transaction will be accounted for in accordance with Securities and Exchange Commission, Staff Accounting Bulletin Topic 2:A:2, whereby Minrad Inc. is deemed to be the accounting acquirer of TAC, followed by a recapitalization. The assets and liabilities of TAC as of the date of acquisition were nominal with the exception to their receivable from Minrad Inc., amounting to $879,557, which is eliminated upon consolidation and equity of $866,330. These assets and liabilities were recorded at their fair value and the 5,635,357 previously outstanding TAC shares were recorded as issued for the net equity of TAC as of December 16, 2004. The operations of the consolidated financial statements will include the activities of TAC, now Minrad International, Inc., starting with the date of the acquisition. The financial statements presented prior to December 16, 2004 reflect the operations of only Minrad Inc.

            On August 25, 2004, the Agreement was amended to permit TAC to sell up to 2.5 million shares of its common stock at a price not less than $1.75 per share, provided that the proceeds from the transaction, net of related expenses, are loaned to Minrad Inc. to finance its operations. As of the date of the consummation of the merger, 585,257 shares had been sold for net proceeds of $921,781. From this, loans amounting to $872,500 had been made to Minrad Inc. from TAC, which eliminate upon consolidation. These loans bear interest at the rate of 6%, originally matured in March 2005, and hold a subordinated collateral interest in the assets of Minrad Inc. On March 15, 2005 an amendment was signed extending the maturity date to June 15, 2005. The sale of these shares included the issuance of warrants (see Note 9).

    F-7

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

     

    NOTE 1. - NATURE OF BUSINESS (CONTINUED)

            Information on TAC prior to the merger can be found on their last 10K filed with the Securities and Exchange Commission for their year ended March 31, 2004. The consolidated balance sheet of TAC as of December 16, 2004 and its results of operations for the period April 1, 2004 through December 16, 2004 are as follows:

    TECHNOLOGY ACQUISITION CORPORATION
    Consolidated Balance Sheet
    December 16, 2004

     

    ASSETS

         
    Current assets $

    880,922

         

    Total assets

    $

    880,922

         

    LIABILITIES AND STOCKHOLDERS' EQUITY

         
    Current liabilities $

    14,593

    Total stockholders' equity  

    866,329

         

    Total liabilities and stockholders' equity

    $

    880,922

         

    Consolidated Statement of Operations

    For the period from April 1, 2004 through December 16, 2004

         
    Revenues $

    -

    General and administrative expenses  

    96,511

    Operating loss  

    (96,511)

    Other income  

    7,057

         
    Net loss available to common stockholders $

    (89,454)

         
    Basic net loss per share of common stock $

    (0.02)

         
    Weighted average number of common shares outstanding  

    4,582,052

    See accompanying notes.

    F-8

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 1. - NATURE OF BUSINESS (CONTINUED)

            Year End Change - As a result of the merger, the Company adopted the fiscal year end of Minrad Inc., which was September 30th. Subsequently, the Company has decided to change its year end to December 31st. Accordingly, the accompanying financial statements present the transitional period from October 1, 2004 to December 31, 2004. See Note 17 for unaudited financial statements of Minrad Inc. for the comparative three-month period ended December 31, 2003.

    NOTE 2. - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

            Accounts Receivable - The Company carries its accounts receivable at cost less an allowance for doubtful accounts. An account receivable is considered to be past due if any portion of the receivable balance is outstanding beyond its scheduled due date. On a monthly basis, the Company evaluates its accounts receivable and establishes an allowance for doubtful accounts, based on its history of past write-offs and collections, and current credit conditions. No interest is accrued on past due accounts receivable. The allowance for doubtful accounts was $317,000 as of December 31, 2004 ($420,000 and $355,000 as of September 30, 2004 and 2003, respectively).

            Sale of Certain Accounts Receivable - The Company has adopted Statement of Financial Accounting Standards Board (SFAS) Statement No. 140, "Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities". SFAS 140 provides consistent standards for distinguishing transfers of financial assets that are sales from transfers that are secured borrowings. During the year ended September 30, 2004, the Company established a factoring line with a financial institution (the Purchaser), which enables the Company to sell selected accounts receivable invoices to the Purchaser with full recourse against the Company. These transactions qualify for a sale of assets since (1) the Company has transferred all of its right, title and interest in the selected accounts receivable invoices to the bank, (2) the Purchaser may pledge, sell or transfer the selected accounts receivable invoices, and (3) the Company has no effective control over the selected accounts receivable invoices since it is not entitled to or obligated to repurchase or redeem the invoices before their maturity and it does not have the ability to unilaterally cause the Purchaser to return the invoices. Under SFAS 140, after a transfer of financial assets, an entity recognizes the financial and servicing assets it controls and the liabilities it has incurred, derecognizes financial assets when control has been surrendered, and derecognizes liabilities when extinguished.

            Pursuant to the provisions of SFAS 140, the Company reflects the factoring transactions as a sale of assets and establishes an accounts receivable from the Purchaser for the retained amount less the costs of the transaction and less any anticipated future loss in the value of the retained asset. The retained amount is generally equal to 30% of the total accounts receivable invoice sold to the Purchaser, less 5% of the total invoice as a factoring fee. Further, the Purchaser charges the Company late charges of 24% in the event a payment by the Company's customer to the Purchaser is made 30 days past its due date. The estimated future loss reserve for each receivable included in the estimated value of the retained asset is based on the payment history of the accounts receivable customer and is included in the allowance for doubtful accounts. In connection with the agreement, the Company also has the ability to request advances from the Purchaser against the retained interests. These advances bear interest at the rate of 24%.

    F-9

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 2. - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

                During the period ended December 31, 2004, the Company sold approximately $300,000 ($4.1 million in the fiscal year ended September 2004 and zero in fiscal 2003) of its accounts receivable to the Purchaser under the factoring agreement. As of December 31, 2004, approximately $1.01 million ($1.26 million at September 30, 2004) of these receivables remain outstanding. After deducting estimated fees and advances from the factor, the net receivable from the purchaser amounted to $515,415 at December 31, 2004 ($510,514 at September 30, 2004), and is included in accounts receivable in the accompanying balance sheets. Further, the Company has requested and received an advance from the Purchaser against this retained interest, which amounted to $148,592 as of December 31, 2004 ($161,467 as of September 30, 2004). These amounts have been reflected as a demand note payable as of December 31, 2004 and September 30, 2004 (see Note 6).

                Inventories - Inventories are stated at the lower of cost (first-in, first-out) or market. A reserve for slow-moving and obsolete inventory is established for all inventory deemed potentially non-saleable by management in the period in which it is determined to be potentially non-saleable.

            Property and Equipment - Property and equipment are carried at cost. All assets that require a period of time to prepare for their intended use are classified as contracts in progress until placed in service. If material, interest is capitalized during this period. For the period ended December 31, 2004 approximately $17,000 of interest was capitalized. There was no interest capitalized during the years ended September 30, 2004 or 2003. Depreciation is provided on the straight-line method over the estimated useful lives of the assets ranging from three to five years. Depreciation expense amounted to approximately $25,000 for the period ended December 31, 2004 ($140,000 and $146,000 for the years ended September 30, 2004 and 2003, respectively).

            The Company owns land and a manufacturing facility located in Bethlehem, Pennsylvania, acquired in a business combination during the year ended September 30, 2001. The facility, as well as related machinery and equipment, are used in the Company's anesthesia and analgesia business. At the date of acquisition, the fair value of the assets exceeded the consideration paid. Accordingly, in accordance with SFAS 141 "Business Combinations," there was no value assigned to these assets at the date of acquisition and they have a zero recorded value at December 31, 2004 and September 30, 2004 and 2003.

            Patents - Patents and patent acquisition costs are recorded at cost and amortized over their remaining useful life, not to exceed the legal life. There has been no amortization expense relating to these patents during the periods presented since the patents have yet to be issued and the Company has yet to place the related technology in service.

            Income Taxes - The Company accounts for income taxes in accordance with the provisions of SFAS No. 109, "Accounting for Income Taxes." The standard requires the asset and liability method of accounting for income taxes and the recognition of future tax benefits, measured by enacted tax rates, attributed to deductible temporary differences, and net operating loss carryforwards to the extent that realization of such benefits is more likely than not, as well as future tax obligations attributed to taxable temporary differences.

     

    F-10

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 2. - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

            Revenue Recognition - The Company recognizes revenue from product sales when the goods are shipped to the customer, resulting in the transfer of title and risk of loss.

            Earnings Per Share - The Company has adopted the provisions of SFAS No. 128, "Earnings Per Share." Basic earnings/loss per share is computed by dividing income/loss (numerator) applicable to common stockholders by the weighted number of common shares outstanding (denominator) for the period. Diluted earnings/loss per share assumes the exercise or conversion of all dilutive securities. Diluted loss per share does not differ from basic loss per share for all periods presented due to the net loss and the impact of including potential common shares would be anti-dillutive.

            If the Company had generated earnings during the period ended December 31, 2004, 723,312 common stock equivalent shares would have been added to the weighted averages shares outstanding (none for the years ended September 30, 2004 and 2003). These additional shares represent the assumed conversion of convertible debt and the assumed exercise of common stock options and warrants whose exercise price is less than the average fair value of the Company's stock during the period. The proceeds of the exercise are assumed to be used to purchase common shares for treasury and the incremental shares are added to the weighted average shares outstanding.

            Research and Development Costs - All costs related to research and development are expensed as incurred. These costs include labor and other operating expenses related to product development, as well as costs to obtain regulatory approval.

            Advertising - The Company expenses advertising as incurred. These amounts were not significant for the periods presented.

            Stock Based Compensation - The Company accounts for its stock option plans utilizing the intrinsic value method specified under Accounting Principles Board (APB) Opinion No. 25, "Accounting for Stock Issued to Employees". Accordingly, no compensation expense is recognized for stock options issued to employees as long as the exercise price is greater than or equal to the market value of the common stock at the date of grant. In accordance with SFAS 123, "Accounting for Stock-Based Compensation," the Company discloses the summary of proforma effects to reported net loss as if the Company had elected to recognize compensation costs based on the fair value of the employee options at the grant date (see Recent Accounting Pronouncements below). Stock options and warrants issued to non-employees are recognized as compensation expense based upon the fair value of the consideration received or the fair value of the equity instruments issued, whichever is more reliably measurable.

            Recent Accounting Pronouncements - Subsequent to December 31, 2004, the Financial Accounting Standards Board (FASB) issued a revision to SFAS 123 entitled SFAS 123 R - "Share-Based Payment", requiring companies to include the fair value of stock options granted as an expense in the statement of operations. This revision will become effective for the Company commencing January 1, 2006. See Note 10 for the impact of recording the fair value of options granted.

    F-11

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 2. - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

            Subsequent to December 31, 2004, the FASB issued SFAS 151, "Inventory Costs". This Statement amends the guidance in Accounting Research Bulletin (ARB) No. 43, Chapter 4, "Inventory Pricing", to clarify the accounting for abnormal amounts of idle facility expense, freight, handling costs, and wasted material (spoilage). SFAS 151 requires that those items be recognized as current-period charges regardless of whether they meet the criterion of "so abnormal". In addition, this Statement requires that allocation of fixed production overheads to the costs of conversion be based on the normal capacity of the production facilities. Statement 151 is effective for inventory costs incurred during fiscal years beginning after June 15, 2005, with earlier application permitted in certain circumstances. The Company will adopt this new standard January 1, 2005. Adopting this new standard is not expected to have a significant impact on the Company's financial statements.

            Accounting Estimates - The process of preparing financial statements in conformity with accounting principles generally accepted in the United States of America requires the use of estimates and assumptions regarding certain types of assets, liabilities, revenues, and expenses. Such estimates primarily relate to unsettled transactions and events as of the date of the financial statements. Accordingly, actual results may differ from estimated amounts.

            Segment Reporting - In applying the provisions of SFAS 131 "Segment Reporting", management has determined that the Company is organized, managed and internally reported as one business segment (see Note 16).

            Fair Value of Financial Instruments - The carrying amount of cash and cash equivalents, accounts receivable, inventories, accounts payable and accrued expenses are reasonable estimates of their fair value due to their short maturity. Based on the borrowing rates currently available to the Company for loans similar to its term debt and notes payable, the fair value approximates its carrying amount.

            Concentration of Credit Risk - Financial instruments that potentially subject the Company to concentration of credit risk consist of cash accounts in financial institutions. Although the cash accounts exceed the federally insured deposit amount, management does not anticipate nonperformance by the financial institutions.

            Reclassifications - Certain amounts included in the year ended September 30, 2004 and 2003 financial statements have been reclassified to conform with the December 31, 2004 presentation.

    F-12

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

     

    NOTE 3. - CONTINUING OPERATIONS

            The Company has incurred substantial operating losses since inception. At December 31, 2004, the Company had a working capital deficit of approximately $4.0 million and a stockholders' deficit of approximately $3.4 million. The Company expects to and has devoted substantial capital resources for research and development of new products and for expanding its operations through internal growth and strategic acquisitions as in the past. The Company anticipates that the introduction of a new-FDA approved inhalation anesthetic and the Company's second-generation real-time image guidance system in fiscal 2005 will have a positive impact on revenue growth and cash flows in 2005 and beyond.

            The Company's business plan anticipates such activities described above will be funded from the issuance of additional equity or debt securities. There can be no assurance that such additional financing, if necessary, will be available on terms acceptable to the Company or at all. Failure to raise the funds necessary to finance future cash requirements could adversely affect the Company's ability to pursue its strategy and could negatively affect operations in future periods. The accompanying financial statements do not reflect any adjustments that may be necessary in the event the Company is unsuccessful in its fundraising efforts.

            See Note 18 for details related to $2.5 million in convertible promissory notes that were issued in February 2005.

     

    NOTE 4. - INVENTORIES

            Inventories consist of the following at:

       

    December 31,

    September 30,

       

    2004

    2004

    2003

                   
     

    Raw materials

    $

    383,355

      $

    456,119

      $

    460,312

     
     

    Work-in-progress

    466,421

     

    365,981

     

    522,610

     
     

    Finished goods

    944,789

     

    1,011,592

     

    1,071,013

     
       

    1,794,565

     

    1,833,692

     

    2,053,935

     
                   
     

    Less reserve for slow moving and obsolete inventory

    725,000

     

    725,000

     

    725,000

     
                   
        $

    1,069,565

      $

    1,108,692

      $

    1,328,935

     

    F-13

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 5. - OTHER ASSETS

            Other assets consist of the following at:

       

    December 31,

     

    September 30,

     
       

    2004

     

    2004

     

    2003

     
      Patent applications $

    64,207

      $

    57,805

      $

    -

     
      Restricted deposits (A)

    48,591

     

    43,322

     

    55,475

     
                   
        $

    112,798

      $

    101,127

      $

    55,475

     

            (A) In connection with the Bayview promissory note (see Note 7) the Company was required to maintain two restricted deposit accounts. Under the holdback agreement, the lender retained $68,182 of the original proceeds as a reserve to ensure payment of monthly loan payments. This balance less amounts applied against principal and interest payments amounted to $35,417 at December 31, 2004 ($35,417 and $54,530 at September 30, 2004 and 2003, respectively). In addition, the Company is also required to maintain a restricted deposit account for the payment of taxes that amounted to $13,174 at December 31, 2004 ($7,905 and $945 at September 30, 2004 and 2003, respectively).

     

    F-14

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 6. - DEMAND NOTES PAYABLE

     

    December 31,

    September 30,

     

    2004

    2004

    2003

           
    Wachovia Bank, N.A. - a demand note with interest payable monthly at 1.25% above the Lender's monthly LIBOR Index rate (2.28% at December 31, 2004). The note is secured by all assets of the Company and is guaranteed by Kevin Kimberlin Partners L.P. (KKP). Kevin Kimberlin is an officer of Spencer Trask Specialty Group. As consideration for this guarantee, the Company issued warrants to KKP to purchase 2,500,000 million shares of common stock, of which, 1,000,000 shares were granted in August 2001 and 1,500,000 were granted in December 2001. The warrants are exercisable for $1 per share, vested immediately and expire December 2008. An agreement was entered into to extend the KKP guarantee. This agreement calls for an additional grant of 50,000 common stock warrants at the beginning of each month that the debt is not repaid, beginning in October 2004. The warrants entitle KKP to purchase shares of common stock at $ 0.75 per share and will expire on varying dates through February 28, 2010. During the period ended December 31, 2004, 150,000 warrants were issued under this agreement. These warrants were valued utilizing the Black-Scholes pricing model, resulting in $116,888 being recorded and included in interest expense for the three months ended December 31, 2004. As of the date of this report, the debt continued to remain outstanding, resulting in the grant of an additional 150,000 warrants subsequent to December 31, 2004.

    $ 997,533

    $ 1,000,000

    $ 1,000,000

    F-15

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 6. - DEMAND NOTES PAYABLE (CONTINUED)

     

    December 31,

    September 30,

     

    2004

    2004

    2003

    Stockholder loans - $325,000 was advanced to the Company through unsecured notes from various stockholders bearing interest at a rate of 6.0%. There were no repayment terms. In connection with these unsecured agreements, the Company granted the shareholders options to purchase an aggregate of 50,000 shares of common stock at an exercise price of $1.95 per share. These options vest on January 1, 2006 and expire on December 31, 2010. The value of these detachable options, recorded as interest expense, amounted to $4,150 during the period ended December 31, 2004. Subsequent to December 31, 2004 the entire balance was repaid.

    325,000

    -

    -

           
    Advance payable - factor, bearing interest at 24% (see Note 2).

    148,592

    161,467

    -

           
    Technology Acquisition Corp. - In connection with the Company's merger with TAC, as of September 30, 2004 TAC has loaned the Company $226,000 under short term notes that bear interest at 6% and are payable in March of 2005. These loans eliminate upon consolidation effective December 16, 2004 (see Note 1).

    -

    226,000

    -

           
    Spencer Trask Specialty Group, LLC (STSG) - A $750,000 convertible promissory note, which accrued interest at a rate of 8.0%. Total principal and interest was due in March 2004. STSG had the election to convert the note into a series of preferred stock to be created with terms acceptable to STSG. During the year ended September 30, 2004, $457,482 of this note was repaid. The remaining $292,518 was sold by STSG to a third party, who converted the amount into 390,024 shares of common stock at a rate of $.75 per share.

    -

    -

    750,000

    F-16

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 6. - DEMAND NOTES PAYABLE (CONTINUED)

     

    December 31,

    September 30,

     

    2004

    2004

    2003

    STSG - A $75,000 convertible promissory note, which accrued interest at a rate of 10.0%. Total principal and interest was due in May 2003. STSG had the election to convert the note into Series B Preferred Stock at a conversion rate of $1.15 per share. In connection with this note agreement, the Company granted STSG warrants to purchase 6,522 shares of common stock at an exercise price of $1.15 per share. These warrants vested immediately and expire in March 2009. The value of the detachable warrants, recorded as a note discount and interest expense, amounted to $1,216 during the year ended September 30, 2003 (B). The value of the beneficial conversion feature of the note amounted to $1,216, resulting in additional interest expense (C). As of September 30, 2003 the outstanding amount was past due. During the year ended September 30, 2004, the entire note was repaid, prior to conversion.

    -

    -

    75,000

           
    STSG - A $250,000 convertible promissory note, which accrued interest at a rate of 10.0%. Total principal and interest was due on March 2003. The outstanding principal was convertible into Series B preferred stock at a conversion rate of $1.15 per share. In connection with this note agreement, the Company granted STSG warrants to purchase 21,739 shares of common stock at an exercise price of $1.15 per share. These warrants vested immediately and expire in March 2009. The value of the detachable warrants, recorded as a note discount, amounted to $4,054, resulting in interest expense of $3,604 during the year ended September 30, 2003. (B). The value of the beneficial conversion feature of the note amounted to $4,054, resulting in additional interest expense. (C). As of September 30, 2003, the outstanding amount was past due. During the year ended September 30, 2004, the entire note was repaid, prior to conversion.

    -

    -

    250,000

    F-17

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 6. - DEMAND NOTES PAYABLE (CONTINUED)

     

    December 31,

    September 30,

     

    2004

    2004

    2003

    STSG - A $500,000 convertible promissory note, which accrued interest at a rate of 10.0%. Total principal and interest was due on March 2003. The outstanding principal was convertible into Series B preferred stock at a conversion rate of $1.15 per share. In connection with this note agreement, the Company granted STSG warrants to purchase 434,783 shares of common stock at an exercise price of $1.15 per share. These warrants vested immediately and expire in March 2009. The value of the detachable warrants, recorded as a note discount, amounted to $95,429, resulting in interest expense of $56,197 during the year ended September 30, 2003. (B). The value of the beneficial conversion feature of the note amounted to $95,429, resulting in additional interest expense. (C). As of September 30, 2003, the outstanding amount was past due. During the year ended September 30, 2004, the entire note was repaid, prior to conversion.

    -

    -

    57,860

     

     

     

     

    New England Partners Capital, LP (NEP) - A $75,000 promissory note which accrued interest at a rate of 8%. Principal and interest was due on demand. During the year ended September 30, 2004, the entire note was repaid.

    -

    -

    75,000

           
    NEP - A $750,000 convertible promissory note, which accrued interest at a rate of 8.0%. Total principal and interest was due in March 2004. NEP had the election to convert the note into a series of preferred to be created which is acceptable to NEP. During the year ended September 30, 2004, the note, as well as accrued interest of $57,611, was converted into 1,076,814 shares of common stock at a rate of $.75 per share.

    -

    -

    750,000

           
    NEP - A $800,000 convertible promissory note, which accrued interest at a rate of 8.0%. Total principal and interest was due on demand. NEP had the election to convert the note into Series B Preferred Stock at a conversion rate of $1.50 per share. During the year ended September 30, 2004, the note, as well as accrued interest of $83,463, was converted into 911,285 shares of common stock at a rate of $1.00 per share ($.75 per share for accrued interest).

    -

    -

    800,000

    F-18

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 6. - DEMAND NOTES PAYABLE (CONTINUED)

     

    December 31,

    September 30,

     

    2004

    2004

    2003

    Lincoln Associates, LLC - A $200,000 demand note to a subsidiary of a stockholder, with interest payable monthly at 8% per annum. In connection with this note payable, the Company issued warrants to purchase common shares equal to $200,000 at a per share price equal to the first private or public offering of the Company's common stock subsequent to the grant of the warrants. The warrants vested immediately and expired in May 2004 unexercised. (A) During the year ended September 30, 2004, the note, as well as accrued interest of $18,762 as of March 15, 2004, was converted into 291,683 shares of common stock at a rate of $.75 per share.

    -

     

    -

     

    200,000

     
                 
    Donald F. Farley (Farley) - A $100,000 convertible promissory note, which accrued interest at a rate of 10.0%. Total principal and interest was due in December 2003. Farley had the election to convert the note into a series of preferred to be created which is acceptable to Farley. Farley is an officer of STSG and is on the board of directors of the Company. During the year ended September 30, 2004, the note, as well as accrued interest of $10,000 as of March 15, 2004, was converted into 146,667 shares of common stock at a rate of $.75 per share.

    -

     

    -

     

    100,000

     
                 
    Other individuals - An aggregate of $111,398 non-interest bearing convertible promissory notes due in December 2002. During the year ended September 30, 2004, the notes were converted into 89,118 shares of common stock at a rate of $1.25 per share.

         -

     

         -

     

    111,398

     
                 
     

    $ 1,471,125

     

    $ 1,387,467

     

    $ 4,169,258

     

            (A) Management has valued the common stock warrants at their date of grant utilizing the Black Scholes pricing model. In arriving at their fair market value at the date of grant, the Company considered, among other things, historic equity transactions for all classes of its stock, the liquidity of the common stock, volatility and the liquidation preference of the Series A and B preferred shares. As a result of this analysis, the assumed value of the underlying common stock at the date of grant was substantially less than its exercise price, resulting in no value being assigned to the common stock warrants.

    F-19

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 6. - DEMAND NOTES PAYABLE (CONTINUED)

            (B) A portion of the proceeds from the issuance of the note has been allocated to the detachable warrants and has been classified as a note discount and additional paid-in capital. Management determined the value of the warrants and note discount utilizing the Black Scholes pricing model. The assumed fair value of the underlying Series B Preferred Stock used in the model was determined to be the par value of $1.15, based on past transactions involving this series of stock. The note discount was classified as a reduction of the note amount in the balance sheet and amortized into income over the term of the note as additional interest expense.

            (C) Based on the reduction of the note-carrying amount as a result of the detachable warrant note discount, the effective conversion rate per share of the notes results in a beneficial conversion feature. The value of this beneficial conversion feature is determined at issuance by comparing the effective conversion price to the fair value of the underlying stock, multiplied by the number of shares into which the debt is convertible. The portion of the proceeds attributed to the beneficial conversion feature is allocated to paid in capital with a corresponding charge to interest expense.

    NOTE 7. - LONG-TERM DEBT

            Long-term debt consists of the following at:

     

    December 31,

    September 30,

     

    2004

    2004

    2003

    Buffalo and Erie County Regional Development Corporation (RDC) - A $300,000 seven-year term loan payable in monthly installments of $3,571 plus interest at 8% through March 2006. Additional annual mandatory principal payments are required in the event the Company generates net income, as defined by the agreement. The loan is collateralized by substantially all assets. As of December 31, 2004 and September 30, 2004 and 2003, the Company was in violation of certain provisions of this agreement, which have not been waived. As a result, the lender has the right and has demanded payment in full. Accordingly, the entire balance has been classified as current.

    $ 214,160

    $ 214,160

    $ 221,429

    F-20

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY
    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 7. - LONG-TERM DEBT (CONTINUED)

     

    December 31,

    September 30,

     

    2004

    2004

    2003

           
    Bayview Loan Servicing - A $875,000 promissory note, secured by a mortgage on certain property. The loan is payable in monthly installments of $11,360, including interest at the rate of 13.5% through November 2016. As of December 31, 2004, and September 30, 2004 and 2003 the Company was delinquent with respect to certain payments, resulting in a default, as defined by the agreement. Accordingly, the entire balance has been classified as current. Subsequent to December 31, 2004, the Company became current on these payments.

    808,149

     

    811,323

     

    841,198

     
                 
    Buffalo Economic Renaissance Corporation (BERC) - A seven-year term loan with interest payable at a rate of 8.25% per annum (14% from the time of default - April 1, 2002). Monthly principal and interest payments of $4,713 begin when certain criteria are met. The note was collateralized by substantially all corporate assets. As of September 30, 2003, the Company was in violation of certain provisions of this agreement, including failure to make timely payments, which have not been waived. As a result, the lender demanded payment in full. Accordingly, the entire balance had been classified as current. During the year ended September 30, 2004, a settlement was reached and all outstanding principal and interest, including legal fees of approximately $81,000, were repaid.

         -

     

         -

     

    209,735

     
     

    1,022,309

     

    1,025,483

     

    1,272,362

     
    Less current maturities, including default reclassifications.

    1,022,309

     

    1,025,483

     

    1,272,362

     
                 
      $

    -

      $

    -

      $

    -

     

            Scheduled aggregate maturities required on long-term debt are as follows:

     

    2005

    $

    244,459

     

    2006

     

    33,508

     

    2007

     

    38,322

     

    2008

     

    43,828

     

    2009

     

    50,125

     

    Thereafter

     

    612,067

       

    $

    1,022,309

    F-21

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 8. - INCOME TAXES

            The deferred tax asset consists of the following components:

     

    December 31,

     

    September 30,

     

    2004

     

    2004

     

    2003

                     
    Federal net operating loss carryforward $

    9,130,000

      $

    8,596,000

      $

    7,132,000

    Research and development credit carryforward  

    252,000

       

    238,000

       

    207,000

    Non-deductible reserves  

    416,800

       

    458,000

       

    432,000

    Unrealized loss on investments  

    240,000

       

    240,000

       

    240,000

    Other temporary differences  

    94,000

       

    83,000

       

    100,000

       

    10,132,800

       

    9,615,000

       

    8,111,000

                     
    Valuation allowance  

    (10,132,800)

       

    (9,615,000)

       

    (8,111,000)

                     
    Net deferred tax asset $

    -

      $

    -

      $

    -

            At December 31, 2004, the Company has operating loss carryforwards (NOL's) of approximately $22,823,000 ($21,500,000 and $17,830,000 at September 30, 2004 and 2003 respectively) and research and development tax credits of approximately $252,000 ($238,000 and $207,000 at September 30, 2004 and 2003, respectively) which begin to expire in the year 2011 through 2024. The utilization of the operating loss and tax credit carry forwards may be limited as a result of ownership changes which have occurred. Due to the uncertainty as to the Company's ability to generate sufficient taxable income in the future to utilize the NOL's before they expire, the Company has recorded a valuation allowance to reduce the gross deferred tax assets to zero.

            The differences between the United States statutory federal income tax rate and the effective income tax rate in the accompanying statements of operations are as follows:

     

    December 31,

     

    September 30,

     

    2004

     

    2004

     

    2003

               
    Statutory United States federal rate

    (34)%

     

    (34)%

     

    (34)%

    State income taxes net of federal benefit

    (6)

     

    (6)

     

    (6)

    Nondeductible debt inducement costs and guarantee fee

    3

     

    6

     

    -

    Change in valuation reserves

    37

     

    34

     

    40

    Effective tax rate

    - %

     

    - %

     

    - %

    F-22

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 9. - EQUITY

            The number of shares authorized for all classes of stock are as follows:

     

    December 31,

     

    September 30,

     

    2004

     

    2004

     

    2003

               
    Common, $.01 par value

    100,000,000

     

    100,000,000

     

    30,000,000

    Preferred, $0.25 par value

    5,000,000

     

    -

     

    -

    Series B Convertible Preferred

    -

     

    -

     

    1,800,000

    Series C Convertible Preferred

    -

     

    -

     

    7,440,000

               
    Total

    105,000,000

     

    100,000,000

     

    39,240,000

            Preferred Stock - Minrad International, Inc. has 5,000,000 shares of preferred stock, each with a $0.25 par value. Pursuant to the Nevada Articles of Incorporation, the board of directors is authorized to fix and determine in a resolution the classes, series and numbers of each class or series. None of the preferred shares have been issued.

            Series B Convertible Preferred Stock - Minrad Inc. Series B Convertible Preferred Stock had a par value of $1.50 per share and was convertible at the option of the holder into common stock at a conversion price of $1.50 per share. The conversion ratio may be adjusted in the event Minrad Inc. issues common stock without consideration or for consideration less than $1.50 per share. Conversion may occur at any time at the option of the holder or is automatic upon completion by Minrad Inc. of an initial public offering of the Company's common stock with gross proceeds of at least $15,000,000 at a price of $4.50 per share. Series B Convertible Preferred Stock will be entitled to receive, when, and if declared by the Board of Directors, non-cumulative dividends at the rate of 8% of $1.50 ("Series B Liquidation Preference") per share before any dividends are declared or paid or set aside for payment on the common stock for that fiscal year. Series B Convertible Preferred Stock had full voting rights and powers and shall be entitled to one vote for each share of common stock to which the shares are convertible into. Effective with the amendment to Minrad Inc.'s articles of incorporation during the year ended September 30, 2004, Series B shares are no longer authorized for issuance of Minrad Inc. and all outstanding Series B convertible preferred stock were converted into common stock.

            Series C Convertible Preferred Stock - Minrad Inc. Series C Convertible Preferred Stock had a par value of $.01 per share and is convertible at the option of the holder into common stock at a conversion price of $1.50. The conversion ratio maybe adjusted in the event Minrad Inc. issues common stock without consideration or for consideration less than $1.50 per share. Conversion may occur at any time at the option of the holder or is automatic upon completion by Minrad Inc. of an initial public offering of the Company's common stock with gross proceeds of at least $15,000,000 at a price of $4.50 per share. Series C Convertible Preferred Stock is not entitled to receive dividend payments. Series C Convertible Preferred Stock has full voting rights and powers and shall be entitled to one vote for each share of common stock to which the shares are convertible into. No Series C Preferred Stock have been issued. Effective with the amendment to Minrad Inc.'s articles of incorporation, during the year ended September 30, 2004, Series C shares are no longer authorized for issuance and all outstanding Series C convertible preferred stock were converted into common stock.

    F-23

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 9. - EQUITY (CONTINUED)

            Stock Transactions - Period Ended December 31, 2004: The Company issued 5,635,257 shares of common stock in connection with the reverse merger on December 16, 2004 (see Note 1). Also, the Company raised $35,000 through the issuance of 20,000 shares of common stock in connection with a private placement to one of its employees for $1.75 per share. There were no related expenses.

            Stock Transactions - Year Ended September 30 2004: The Company raised approximately $4,012,500 through the issuance of 3,211,084 shares of common stock in connection with a private placement for $1.25 per share. Related expenses amounted to $462,500, resulting in net proceeds of $3,550,047. In connection with this private placement the Company granted 320,108 common stock warrants with an exercise price of $1.25. A portion of the proceeds, amounting to $67,370, was allocated to these warrants.

            The Company converted various demand notes payable outstanding as of September 30, 2003 (see Note 6) aggregating $2,253,916 and accrued interest of $173,547 into 2,910,538 shares of common stock. The holders of certain of these notes were offered conversion terms that resulted in the issuance of shares of common stock in excess of the amount stated in the original agreement, as well as 475,000 warrants to purchase common stock. These warrants have an exercise price of $1 per share and expire in December 2007. Accordingly, the conversion was considered to be induced by the Company, resulting in the fair value of the shares issued in excess of the original terms being recorded as a debt conversion cost in the statement of operations. This induced conversion cost amounted to $713,000.

            The Company issued additional convertible demand notes payable to STSG, NEP, and another lender aggregating $485,000. These notes accrued interest at the rate of 8%. There was a beneficial conversion feature included in $185,000 of these notes as a result of a conversion price that was less than the fair value of the Company's common stock. The beneficial conversion feature amounted to $123,000, calculated as the fair value of the excess shares to be issued as a result of the beneficial conversion feature. This amount has been recorded as interest expense in the accompanying statement of operations. All notes were subsequently converted, along with accrued interest of $16,287, into 668,383 shares of common stock.

            The Company converted certain vendor accounts payable, accrued expenses and related party advances, aggregating $84,893, into 67,915 shares of common stock.

            The Series B preferred shareholders converted the 950,000 shares outstanding into 1,140,000 common shares.

            The Company offered all warrant holders one share of common stock in exchange for the retirement of three common stock warrants. As a result of this offer, 44,794 shares of common stock were issued.

            Stock Transactions - Year Ended September 30, 2003: 950,000 Series B Convertible Preferred shares were issued to NEP (see Note 6) in exchange for NEP's investment in Theracardia, Inc., valued at $475,000. Theracardia, Inc. was dissolved in fiscal 2003 resulting in cash proceeds of approximately $460,000 and a loss of $15,000.

    F-24

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 9. - EQUITY (CONTINUED)

            All outstanding Series A Preferred and all but 950,000 Series B Preferred were converted into common stock on a one-to-one basis. This transaction was done in connection with the issuance of the NEP promissory notes (see Note 6).

            Stock Warrants - The following is a summary of the warrant activity:

     

    Number

     

    Weighted

     

    of Warrants

     

    Average

     

    Outstanding

     

    Exercise Price

           
    Outstanding at September 30, 2002 and 2003

    4,017,295

    $

    1.07

    Granted - Year Ended September 30, 2004

    795,108

    $

    1.10

    Forfeited/converted to common stock - 2004

    (177,708)

    $

    1.41

           
    Outstanding at September 30, 2004

    4,634,695

    $

    1.06

    Granted - 10/01/04 - 12/31/04

    208,526

    $

    1.03

           
    Outstanding at December 31, 2004

    4,843,221

    $

    1.06

            The warrants have exercise prices ranging from $.75 to $1.75. All are exercisable as of December 31, 2004 and the years ended September 30, 2004 and 2003. In connection with the pre-merger sale of TAC stock (see Note 1), investment warrants were issued to Cagan McAfee Capital Partners and Associates (CMCP) in accordance with an agreement dated December 31, 2003. Minrad Inc. granted CMCP investment warrants of 10% of the number of shares sold in any equity funding. During the period ended December 31, 2004 there were a total of 58,526 warrants to CMCP included in the total above.

    NOTE 10. - STOCK OPTIONS

            The Company has adopted an incentive stock option plan, which authorizes the grant of up to 7,170,500 options to officers and other employees. Grants under this plan made at an exercise price of not less than 110% of the market value on the date of grant. The options may be exercised in specified increments usually beginning one or two years after the date of grant, and generally expire two to five years from their respective vesting dates or earlier if employment is terminated.

    F-25

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 10. - STOCK OPTIONS (CONTINUED)

            A summary of the status of options granted under the incentive stock option plan is presented below:

       

    Number of Shares Subject to Options

       

    Weighted Average Exercise Price

               
    Outstanding as of September 30, 2002  

    545,750

      $

    1.87

    Granted in fiscal 2003  

    190,000

      $

    1.65

    Forfeited in fiscal 2003  

    (65,000)

      $

    1.70

               
    Outstanding as of September 30, 2003  

    670,750

      $

    1.82

    Granted in fiscal 2004  

    1,876,750

      $

    1.42

    Forfeited in fiscal 2004  

    (279,750)

      $

    1.98

    Exercised in fiscal 2004  

    (15,000)

      $

    1.75

               
    Outstanding as of September 30, 2004  

    2,252,750

      $

    1.47

    Granted to employees 10/1-12/31/04  

    71,667

      $

    1.95

    Granted to non-employees 10/1-12/31/04  

    60,000

      $

    1.95

    Forfeited in period 10/1-12/31/04  

    (23,500)

      $

    1.73

    Exercised in period 10/1-12/31/04  

    -

      $

    -

               
    Outstanding as of December 31, 2004  

    2,360,917

      $

    1.50

               
    Exercisable as of December 31, 2004  

    527,470

      $

    1.60

            Options outstanding as of December 31, 2004 had exercise prices ranging from $1.40 to $2.40. The weighted average remaining contractual life of the options outstanding was 5.7 as of December 31, 2004 (5.5 and 1.7 years as of September 30, 2004 and 2003, respectively).

            The Company applies APB Opinion No. 25 in accounting for its stock option plan. Accordingly, no compensation expense has been charged to earnings for options granted to employees for the period ended December 31, 2004 and the years ended September 30, 2004 or 2003 since all such options have an exercise price greater than the market value on the date of grant. During the period ended December 31, 2004 a total of 60,000 options at a value of $4,150 were granted to non-employees at an exercise price of $1.95, which all have an exercise price greater than the market value at the date of grant.

            The weighted average fair value of the options granted to employees during the period ended December 31, 2004 was $.14 per share ($.12 per share during the year ended September 30, 2004.)

            If the Company had elected to recognize compensation cost based on the fair value of the options granted at grant date as prescribed by SFAS No. 123, net loss would have increased as follows. Proforma earnings per share does not change from the amounts reported as a result of fair value compensation.

    F-26

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 10. - STOCK OPTIONS (CONTINUED)

     

    Three -Month Period Ended December 31,

     

    Year Ended
    September 30,

     

    2004

     

    2004

     

    2003

    Net loss-as reported (000's) $

    (1,380)

    $

    (4,545)

    $

    (2,796)

                 
    Total stock based employee compensation expense
    determined under fair value method for all awards (000s)
     

    (28)

     

    (47)

     

    -

                 
    Net loss- pro forma (000's) $

    (1,408)

    $

    (4,592)

    $

    (2,796)

            Management has valued the options at their date of grant utilizing the Black Scholes pricing model. The assumed value of the underlying common stock for the year ended September 30, 2003 was not significant in relation to the exercise price, resulting in no value being assigned to the options. The following weighted-average assumptions were utilized in the fair value calculations:

     

    December 31,

     

    September 30,

     

    2004

     

    2004

    Expected dividend yield

    0%

     

    0%

    Expected stock price volatility

    0%

     

    0%

    Risk-free interest rate

    3.96%

     

    4.02%

    Expected life of options

    6.0 years

     

    6.5 years

    NOTE 11. - RELATED PARTY TRANSACTIONS

            A related party is generally defined as (i) any person that holds 10% or more of the Company's securities and their immediate families, (ii) the Company's management, (iii) someone that directly or indirectly controls, is controlled by or is under common control with the Company, or (iv) anyone who can significantly influence the financial and operating decisions of the Company. A transaction is considered to be a related party transaction when there is a transfer of resources or obligations between related parties.

            Minrad is indebted to Biosight, Inc., a healthcare consulting firm currently inactive, and Biovision, Inc., a medical products firm also currently inactive. Stockholders of the Company are also stockholders in these companies and Kevin Kimberlin Partners, L.P. The amounts outstanding are unsecured.

            Due to affiliates is comprised of the following:

     

    December 31,

       

    September 30,

     

    2004

       

    2004

       

    2003

    Biosight, Inc. $

    187,809

      $

    222,309

      $

    248,545

    Biovision, Inc.  

    88,600

       

    85,981

       

    77,965

    Employee advances and notes  

    73,774

       

    76,512

       

    92,890

    Kevin Kimberlin Partners LP  

    24,557

       

    19,103

       

    4,259

                     
      $

    374,740

      $

    403,905

      $

    423,659

    F-27

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 11. - RELATED PARTY TRANSACTIONS (CONTINUED)

            In addition, interest expense on debt owed to stockholders and affiliates of the Company (STSG, NEP, Farley, Lincoln Associates - see Note 6) amounted to approximately $131,000 for the period ended December 31, 2004 ($316,000 and $503,000 for the years ended September 30, 2004 and 2003, respectively). Debt conversion costs of $713,000 for the year ended September 30, 2004 were also attributed to the stockholders.

    NOTE 12. - MAJOR CUSTOMERS

            Revenue for the period ended December 31, 2004 and years ended September 30, 2004 and 2003 included sales to the following major customers (which each individually accounted for 10% or more of the total net sales of the Company during any one period or more) as follows.

       

    Three-Month Period Ended December 31, 2004

     

    Year Ended

    September 30, 2004

     

    Year Ended

    September 30, 2003

    Customer

     

    Revenues

     

    Percentage of Revenues

     

    Revenues

     

    Percentage of Revenues

     

    Revenues

     

    Percentage of Revenues

    A $

    91,464

     

    20%

    $

    403,750

     

    10%

    $

    -

     

    -%

    B  

    87,000

     

    19

     

    539,600

     

    13

     

    279,000

     

    8

    C  

    50,000

     

    11

     

    255,875

     

    6

     

    136,900

     

    4

    D  

    35,633

     

    8

     

    402,170

     

    10

     

    464,995

     

    13

    E  

    -

     

    -

     

    442,498

     

    11

     

    212,670

     

    6

    F  

    -

     

    -

     

    329,287

     

    8

     

    484,891

     

    14

     

    $

    264,097

     

    58%

    $

    2,373,180

     

    58%

    $

    1,578,456

     

    45%

    NOTE 13. - RETIREMENT PLAN

            The Company has a 401(k) plan providing retirement benefits for its employees. All employees who complete six months of service and are twenty-one years of age are eligible to participate in the plan. The Company may elect to make discretionary contributions. Retirement plan expense amounted to approximately $12,000 for the period ended December 31, 2004 ($39,000 and $81,000 for the years ended September 30, 2004 and 2003, respectively).

    NOTE 14. - COMMITMENTS AND CONTINGENCIES

            The Company has a license agreement with the Research Foundation of the State University of New York at Buffalo (the Foundation), which requires the Company to pay the Foundation a royalty equal to 1% of the net revenue generated from sales of the DRTS platform until such time as the Company transacts a public offering or is acquired by a third party. There were no sales of the platform during the three-month period ended December 31, 2004 and the year ended September 30, 2004 ($29,000, for the year ended September 30, 2003).

            The Company currently rents office and warehouse space under a lease agreement which expires in December 2006 and calls for monthly rental payments of $16,165 per month over the term of the lease. The Company is also responsible for their proportional share of various shared costs of the landlord, which include taxes, utilities and operating expenses. Rental expense under the term of this lease agreement amounted to

    F-28

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 14. - COMMITMENTS AND CONTINGENCIES (CONTINUED)

    approximately $48,000 for the three-month period ended December 31, 2004 ($248,000 and $231,000 for the years ended September 30, 2004 and 2003, respectively).

    Approximate future minimum lease commitments are estimated as follows for the years ended December 31:

    2005 $

    194,000

    2006  

    194,000

      $

    388,000

            Various claims and actions against the Company considered normal to the Company's business, have been asserted and are pending against the Company. Management believes that the resolution of such claims and actions should not have any material adverse effect on the results of operations or the financial position of the Company.

            On February 16, 2003, a winter snowstorm shut down the Company's Pennsylvania manufacturing plant for a period of weeks, and limited subsequent production until mid-July 2003. A business interruption claim was filed against the insurance carrier. An initial payment of $500,000 was received in August 2003, which was recorded as a reduction to cost of sales in fiscal 2003. The remaining claim is pending and the ultimate results are undeterminable at this time.

    NOTE 15. - SUPPLEMENTAL CASH FLOW INFORMATION

            Cash paid for interest amounted to $70,380 for the three-month period ended December 31, 2004 ($729,217 and $378,943 for the years ended September 30, 2004 and 2003, respectively). There was no cash paid for income taxes during the three-month period ended December 31, 2004 and the years ended September 30, 2004 and 2003.

     

     

    Three-Month Period Ended December 31,

     

    Years Ended

    September 30,

     

     

    2004

     

    2004

     

    2003

    Noncash investing and finance activities:

     

     

     

     

     

     

    Conversion of demand notes and accrued interest into common stock

    $

    -

    $

    2,928,750

    $

    -

     

     

     

     

     

     

     

    Conversion of employee advances into common stock

    $

    -

    $

    17,421

    $

    -

     

     

     

     

     

     

     

    Conversion of accounts payable into common stock

    $

    -

    $

    67,472

    $

    -

     

     

     

     

     

     

     

    Series A and B preferred stock converted to common

    $

    -

    $

    475,000

    $

    10,125,563

     

     

     

     

     

     

     

    Equipment acquired by the assumption of current liabilities

    $

    -

    $

    50,980

    $

    -

     

     

     

     

     

     

     

    Investment received in exchange for Series B preferred stock

    $

    -

    $

    -

    $

    475,000

     

     

     

     

     

     

     

    Note discount for value of detachable warrants granted with demand note

    $

    -

    $

    -

    $

    225,476

     

     

     

     

     

     

     

    Beneficial conversion feature of demand demand notes

    $

    -

    $

    -

    $

    225,476

    F-29

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 16. - BUSINESS SEGMENT INFORMATION

            The Company operates its business in one reportable segment. The Company has two product lines as follows:

       • Anesthesia and Analgesia - We currently manufacture and sell two halogenated inhalation anesthetics, Isoflurane and Enflurane.
         
       • Real-Time Image Guidance - As of December 31, 2004, this product line of the Company is still in the engineering and development stage with the product launch scheduled for 2005.

            Currently, the Company does not separately manage these product lines due to the development stage and minor size of the of the Real-Time Image Guidance segment. There are no intersegment transactions.

       

    Three-Month Period Ended December 31,

     

    Years Ended
    September 30

       

    2004

     

    2004

     

    2003

    Revenues by geographic area (000's):            

    North America

    $

    201

    $

    1,155

    $

    909

    International

     

    259

     

    2,962

     

    2,606

                 

    Total revenues

    $

    460

    $

    4,117

    $

    3,515

            All of the Company's assets are physically located in the United States.

    F-30

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 17. - UNAUDITED COMPARATIVE FINANCIAL STATEMENTS

            Following is the unaudited condensed financial statements of Minrad Inc. as of and for the three month period ended December 31, 2003.

    Balance Sheet

    December 31, 2003

    UNAUDITED

     

     

     

    ASSETS

     

     

     

     

     

    Current Assets

    $

    1,783,979

    Net property and equipment

     

    373,395

    Other assets

     

    414,326

     

     

     

    Total assets

    $

    2,571,700

     

     

     

    LIABILITIES AND STOCKHOLDER'S DEFICIT

     

     

     

     

     

    Current liabilities

    $

    9,607,846

    Stockholder's deficit

     

    (7,036,146)

     

     

     

    Total liabilities & stockholder's deficit

    $

    2,571,700

     

     

     

    Statement of Operations

    For the Period Ended December 31, 2003

    UNAUDITED

     

     

     

    Revenue

    $

    1,049,362

    Cost of goods sold

     

    905,856

    Gross profit

     

    143,506

     

     

     

    Operating expenses

     

    1,016,229

    Operating loss

     

    (872,723)

    Interest expense

     

    276,481

     

     

     

    Net loss

    $

    (1,149,204)

    F-31

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARY

    NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

     

    NOTE 17. - UNAUDITED COMPARATIVE FINANCIAL STATEMENTS (CONTINUED)

    Statement of Cash Flows
    For the Period Ended December 31, 2003
    UNAUDITED

         
    Cash flows from operating activities:    
       Net loss $

    (1,149,204)

       Adjustments to reconcile net loss to net cash used by operating activities:  

    875,200

    Net cash used by operating activities  

    (274,004)

         
    Net cash used by investing activities  

    (434,810)

         
    Net cash provided by financing activities  

    784,682

         
    Net change in cash  

    75,868

         
    Cash - beginning of period  

    750

         
    Cash - end of year  

    76,618

    NOTE 18. - SUBSEQUENT EVENTS

            In February 2005, the Company obtained financing for $2.5 million, which includes (1) convertible promissory notes with an aggregate principal amount of $2.5 million and (2) warrants to purchase, at any time prior to January 30, 2007, an aggregate of 375,000 shares of the Company common stock at $1.75. The convertible promissory notes mature on October 7, 2005, but are subject to prepayment at the option of either the Company or the holders commencing seven business days after the Company has received $5 million or more of gross proceeds from sales of equity securities subsequent to January 1, 2005. Contingent on the receipts of not less than $5 million of gross proceeds from sales of equity securities by the Company subsequent to January 1, 2005, the holders may convert all or any portion of the convertible promissory notes, including any accrued interest thereon, at anytime or from time to time, into common stock at $1.75 per share. The convertible promissory notes will bear interest at a rate of 6% per annum payable at maturity, and will be secured by a second mortgage on the Company's production facility in Bethlehem, Pennsylvania.

            In 2005, 321,714 shares of the Company's stock were sold with net proceeds of $506,700. The Company granted 32,171 warrants in connection with this sale. These warrants vest immediately, expire after seven years and are exercisable for $1.75 per share.

    F-32

     

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARIES

    CONSOLIDATED BALANCE SHEETS (UNAUDITED)
     

     

       

    March 31,

     

    December 31,

    ASSETS  

    2005

     

    2004

             
    Current Assets:        
      Cash $

    134,557

    $

    2,930

    Accounts receivable, net

    1,661,965

    606,229

    Inventories, net

    1,004,192

    1,069,565

    Prepaid expenses

    405,392

    472,049

     

    Total current assets

     

    3,206,106

     

    2,150,773

             
    Property and Equipment:        
    Machinery and equipment

    1,080,530

    721,501

    Computers

    144,895

    128,949

    Furniture and fixtures

    22,641

    22,641

    Construction in progress

    -

    300,241

    1,248,066

    1,173,332

    Less accumulated depreciation

    712,688

    674,126

             

    Total property and equipment

     

    535,378

     

    499,206

             
    Other Assets  

    368,293

     

    112,798

             
      $

    4,109,777

    $

    2,762,777

             
    LIABILITIES AND STOCKHOLDERS' DEFICIT    
             
    Current Liabilities:        
    Demand notes payable        
      Stockholders' and affiliates $

    1,739,538

    $

    325,000

      Wachovia Bank and others  

    997,533

     

    1,146,125

    Accounts payable  

    1,800,385

     

    2,433,859

    Accrued expenses  

    811,179

     

    824,812

    Due to affiliates  

    307,465

     

    374,740

    Current portion of long-term debt,        
      including default reclassifications  

    842,976

     

    1,022,309

     

         Total current liabilities

     

    6,499,076

     

    6,126,845

             
    Stockholders' deficit  

    (2,389,299)

     

    (3,364,068)

             
      $

    4,109,777

    $

    2,762,777

     

    See accompanying notes.

    F-33

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARIES

    CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)
     

     

     

       
     

    Three Months Ended

    Three Months Ended

     

    March 31, 2005

    March 31, 2004

         
    Revenue

    $

    2,428,728

    $

    878,451

             
    Cost of goods sold  

    1,270,272

     

    659,613

             
    Gross profit  

    1,158,456

     

    218,838

             
    Operating expenses:        
      Sales and marketing  

    309,012

     

    180,482

      Research and development  

    338,316

     

    234,151

      Finance and administrative  

    652,443

     

    391,074

    Total operating expense

     

    1,299,771

     

    805,707

             
    Operating loss

    $

    (141,315)

    $

    (586,869)

             
    Non-operating expenses:        
      Interest expense:        
      Stockholders and affiliates  

    (692,344)

     

    (184,809)

      Other  

    (61,629)

     

    (44,759)

            Debt conversion costs  

    -

     

    (713,000)

    Total non-operating expense

     

    (753,973)

     

    (942,568)

             
    Net Loss

    $

    (895,288)

    $

    (1,529,437)

             
    Net Loss per share, basic and diluted

    $

    (.03)

    $

    (.10)

             
    Weighted average common shares outstanding, basic and diluted  

    28,236,653

     

    15,062,869

             
    See accompanying notes.

    F-34

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARIES

    CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' DEFICIT (UNAUDITED)
    For the Quarter Ended March 31, 2005
     

     

    Common

    Additional

    Stock

    Paid-In

    Accumulated

    Shares

    Amount

    Capital

    Deficit

    Total

    Balance at December 31, 2004

    28,019,153

    $

    280,192

    $

    20,512,202

    $

    (24,156,462)

    $

    (3,364,068)

    Sale of common stock, net of costs

    321,714

    3,217

    431,965

    -

    435,182

    Stock options exercised

    5,000

    50

    8,700

    -

    8,750

    Warrants issued with demand notes

    -

    -

    925,188

    -

    925,188

    Warrants issued on Wachovia guarantee

    -

    -

    500,937

    -

    500,937

    Net loss      

    (895,288)

    (895,288)

    Balance at March 31, 2005

    28,345,867

    $

    283,459

    $

    22,378,992

    $

    (25,051,750)

    $

    (2,389,299)

    See accompanying notes.

     F-35

     

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARIES

    CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' DEFICIT (UNAUDITED)
    For the Quarter Ended March 31, 2004
     

     

    Series B

    Convertible

    Preferred

    Common

    Additional

    Stock

    Stock

    Paid-In

    Accumulated

    Shares

    Amount

    Shares

    Amount

    Capital

    Deficit

    Total

    Balance at December 31, 2003

    950,000

    $

    475,000

    14,155,485

    $

    141,555

    $

    11,727,531

    $

    (19,380,232)

    $

    (7,036,146)

    Beneficial conversion feature of demand notes payable

    -

    -

    -

    -

    123,000

    -

    123,000

    Debt conversion costs

    -

    -

    -

    -

    713,000

    -

    713,000

    Conversion of liabilities to equity

    -

    -

    2,846,049

    28,460

    2,370,984

    -

    2,399,444

    Sale of common stock, net of costs

    -

    -

    1,216,084

    12,161

    1,303,092

    -

    1,315,253

    Conversion of series B preferred stock to common stock

    (950,000)

    (475,000)

    1,140,000

    11,400

    463,600

    -

    -

    Net loss

    -

    -

    -

    -

    -

    (1,529,437)

    (1,529,437)

                           
    Balance at March 31, 2004

    -

    $

    -

    19,357,618

    $

    193,576

    $

    16,701,207

    $

    (20,909,669)

    $

    (4,014,886)

    See accompanying notes.

     F-36

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARIES


    CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)

     

    Three Months

    Three Months

    Ended March 31

    Ended March 31,

    2005

    2004

    Cash flows from operating activities:
    Net loss

    $

    (895,288)

    $

    (1,529,437)

    Adjustments to reconcile net loss to net
        cash used by operating activities:
    Depreciation

    38,563

    31,389

    Decrease in allowance for doubtful accounts

    (50,000)

    -

    Debt conversion costs

    -

    713,000

    Amortization of note discount

    164,726

    123,000

    Warrants issued for guarantee

    500,937

    -

    (Increase) decrease in assets:
                 Accounts receivable- trade

    (1,005,737)

    30,879

                 Inventory

    65,373

    (11,374)

                 Prepaid expenses

    66,657

    114,718

    Increase (decrease) in liabilities:
                 Accounts payable

    (633,472)

    (144,894)

                 Accrued expenses

    (13,636)

    35,215

    Net cash used by operating activities

    (1,761,877)

    (637,504)

    Cash flows from investing activities:
    Purchases of property and equipment

    (74,734)

    (20,390)

    Acquisition of other assets

    (33,650)

    (5,035)

    Net cash used by investing activities

    (108,384)

    (25,425)

    Cash flows from financing activities:
    Net decrease (increase) in restricted deposits

    (3,634)

    13,620

    Net repayments to affiliates

    (67,275)

    (23,604)

    Borrowings under demand notes payable

    2,500,000

    402,474

    Repayments under demand notes payable

    (473,592)

    (1,259,480)

    Repayment under long term debt

    (179,333)

    (211,395)

    Proceeds from sale of common stock, net of costs

    435,182

    1,315,253

    Proceeds from options exercised

    8,750

    -

    Deferred financing costs

    (218,210)

    -

    Net cash provided by financing activities

    2,001,888

    236,868

    Net increase (decrease) in cash

    131,627

    (426,061)

    Cash-beginning of period

    2,930

    426,619

    Cash-end of period

    $

    134,557

    $

    558

    See accompanying notes.

     F-37

    MINRAD INTERNATIONAL, INC. AND SUBSIDIARIES
     

    NOTES TO THE FINANCIAL STATEMENTS

     

    NOTE 1: BASIS OF PRESENTATION

    The accompanying unaudited consolidated financial statements of MINRAD International, Inc. and its wholly owned Subsidiaries (the "Company") have been prepared in accordance with accounting principles generally accepted in the United States of America for interim financial information and with the instructions to Form 10-QSB. Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States of America for complete financial statements. In the opinion of management, all adjustments considered necessary for fair presentation have been included. All such adjustments are of a normal recurring nature. Operating results for the three-month period ended March 31, 2005 are not necessarily indicative of the results that may be expected for the year ended December 31, 2005. For further information, refer to the Company's consolidated financial statements and footnotes as of and for the periods ended December 31, 2004 and September 30, 2004 and 2003 as filed with the Securities and Exchange Commission on Form 10-KSB on March 31, 2005.

     

    NOTE 2: MERGER

    As fully disclosed in the December 31, 2004 Form 10-KSB, on December 16, 2004, MINRAD Inc. consummated a Merger Agreement with Technology Acquisition Corporation (TAC, now MINRAD INTERNATIONAL, INC.) and its subsidiary. As of that date, the operations of the consolidated financial statements include the activity of the merged entities. The financial statements presented for the three months ended March 31, 2004 reflect the operations of only MINRAD Inc.

     

    NOTE 3: MINRAD EU

    MINRAD EU, a wholly owned subsidiary of MINRAD, Inc., was formed in February 2005 to hold existing and obtain future European pharmaceutical or image guidance registrations.  Also, acting as a sales headquarters for several of our future international sales managers, the office will be used to support our various distribution partners. This includes E. Merck with whom the Company signed a pharmaceutical distribution agreement in February 2005 and various other current and future distributors.  MINRAD EU will set up a laboratory to conduct finished product testing of our pharmaceutical products according to the European requirements.

     

    NOTE 4: DEMAND NOTES PAYABLE

    In February 2005, the Company obtained financing of $2.5 million, which includes (1) convertible promissory notes with an aggregate principal amount of $2.5 million which bear interest at 6% and matures in October 2005; and (2) warrants to purchase, at any time prior to January 30, 2007, an aggregate of 375,000 shares of the

    F-38

    Company common stock at $1.75 per share. These warrants were valued using the Black Scholes pricing model at $925,188 which was recorded as a note discount and is being amortized into non cash interest over the life of the note. During the three months ended March 31, 2005 the amortization totaled $164,726.  The remaining unamortized balance of $760,462 is reflected as a reduction to the face value of the note on the accompanying balance sheet.

    On May 11, 2005, the parties amended provisions of the convertible notes relating to optional prepayment, optional acceleration, and optional conversion rights. As amended, each of these provisions, which were formerly triggered by the completion of $5 million of equity funding, is now triggered by the existence of aggregate outstanding indebtedness owed by the Company and its subsidiaries (on a consolidated basis) to one or more banks ("Bank Borrowing") in excess of $5 million. If Bank Borrowing in excess of $5 million occurs, then (1) commencing 7 business days thereafter the Company will have the option to prepay the notes, (2) commencing 7 business days thereafter the lenders will have the right to accelerate the maturity date of the notes, and (3) commencing on that date the lenders will have the right to convert all or any portion of the outstanding notes into shares of the Company's Common Stock at $1.75 per share.  In the event the lenders obtain the ability to convert their notes into shares of the Company's common stock based on the terms of the agreement, the Company will be required to record an interest charge of approximately $1.6 million attributed to the beneficial conversion feature at $1.75 per share.

    In connection with the continuing guarantee agreement related to the Wachovia Bank demand note, an additional 150,000 warrants to purchase common stock at $.75 per share were granted to Kevin Kimberlin Partners L.P. (KKP) in the three months ended March 31, 2005.  The warrants, which vest immediately and expire on various dates through May 2010, were valued using the Black Scholes pricing model, resulting in $500,937 being recorded and included in interest expense for the three months ended March 31, 2005.  As of the date of this report the debt continued to remain outstanding resulting in the grant of an additional 100,000 warrants subsequent to March 31, 2005.


    NOTE 5: EQUITY

    During the three months ended March 31, 2005 the Company sold 321,714 shares of the Company's stock at the price of $1.75 per share with the net proceeds of $435,182. The Company granted 32,171 warrants exercisable at $1.75 per share in connection with this sale which vested immediately and expire after seven years.


    NOTE 6: SUPPLEMENTAL CASH FLOW INFORMATION

    Cash paid for interest during the three-month period ended March 31, 2005 amounted to $61,629 (compared to $363,505 in 2004). There was no cash paid for income taxes during the three-month period ended March 31, 2005 and 2004.

       

    2005

     

    2004

    Noncash investing and financing activities:        
             
    Conversion of demand notes and accrued interest into common stock

    $

    -

    $

    2,347,592

             
    Conversion of accounts payable into common stock

    $

    -

    $

    51,852

             
    Series B preferred stock converted to common stock

    $

    -

    $

    475,000

             
    Note discount for value of detachable warrants granted with demand notes

    $

    925,188

    $

    -

    F-39

    NOTE 7: STOCK OPTIONS

    The Company adopted a 2004 Stock Option Plan, which authorizes the grant of up to 7,170,500 options to officers and other employees. To date, options granted under this plan have been incentive stock options with an exercise price of not less than 110% of the market value on the day of grant. The options may be exercised in specific increments usually beginning one or two years after the date of grant, and generally expire two to five years from their respective vesting dates or earlier if the employment is terminated.

    A summary of the status of options granted under the stock option plan for the three months ended March 31, 2005 is presented below:

     

         

    Weighted

     

    Number of

     

    Average

     

    Shares Subject

     

    Exercise

     

    To Options

     

    Price

           
    Outstanding as of December 31, 2004

    2,360,917

    $

    1.50

      Granted to employees 1/1-3/31/05

    352,000

    $

    3.86

      Forfeited in period 1/1-3/31/05

    (2,000)

    $

    1.52

      Exercised in period 1/1-3/31/05

    (5,000)

    $

    1.75

           
    Outstanding as of March 31, 2005

    2,705,917

    $

    1.80

           
    Exercisable as of March 31, 2005

    618,548

    $

    1.58

    Options outstanding as of March 31, 2005 had exercise prices ranging from $1.40 to $4.50

    The Company applies APB Opinion No. 25 in accounting for its stock option plan. Accordingly, no compensation expense has been charged to earnings for options granted to employees for the period ended March 31, 2005 since all such options have an exercise price greater than the market value on the date of grant.

    The weighted average fair value of the options granted to employees during the period ended March 31, 2005 was $2.34 per share ($.17 for 2004).

    If the Company had elected to recognize compensation cost based on the fair value of the options granted at grant date as prescribed by SFAS No. 123, net loss would have increased as follows.

    F-40

        Three-Month  

    Three-Month

        Period Ended  

    Period Ended

        March 31,  

    March 31,

        2005  

    2004

             
    Net loss as reported

    $

    (895,288)

    $

    (1,529,437)
             
    Total stock-based employee        
    compensation expense determined        
    under fair value method for all        
    awards

    $

    (61,647)

    $

    (1,462)
             
    Net loss- pro forma

    $

    (956,935)

    $

    (1,530,899)

     

    Management has valued the options at their date of grant utilizing the Black Scholes pricing model. The following weighted-average assumptions were utilized in the fair value calculations:

     

     

    March 31,
    2005

    March 31,
    2004

                 
    Expected dividend yield

    0

      % 0   %
    Expected stock price volatility

    34

      % 0   %
    Risk-free interest rate

    4

      % 4   %
    Expected life of options

    8

      years 6   years

     

    NOTE 8: RELATED PARTY TRANSACTIONS

    A related party is generally defined as (i) any person that holds 10% or more of the Company's securities and their immediate families, (ii) the Company's management, (iii) someone that directly or indirectly controls, is controlled by or is under common control with the Company, or (iv) anyone who can significantly influence the financial and operating decisions of the Company. A transaction is considered to be a related party transaction when there is a transfer of resources or obligations between related parties.

    The Company is indebted to Biosight, Inc., a currently inactive healthcare consulting firm, and Biovision, Inc., a medical products firm also currently inactive. Certain executive officers and greater than 10% stockholders of the Company are also stockholders in these companies, and certain greater than 10% stockholders of the Company are also stockholders of Kevin Kimberlin Partners, L.P. The amounts outstanding are unsecured.

    Due to affiliates is comprised of the following:

    F-41

       

    March 31

     

    December 31

       

    2005

     

    2004

             
    Biosight, Inc.

    $

    159,533

    $

    187,809

    Biovision, Inc.  

    91,300

     

    88,600

    Employee advances and notes  

    28,936

     

    73,774

    Kevin Kimberlin Partners, L.P.  

    27,696

     

    24,557

             
     

    $

    307,465

    $

    374,740

     

    NOTE 9: SUBSEQUENT EVENTS

    In April 2005, the Board of Directors and shareholders of the Company approved the Directors Compensation Plan effective April 21, 2005. The plan's purpose is to compensate the Outside Directors for attending meetings of the Board at the rate of $1,000 per meeting, and Committee meetings at the rate of $500. Payment will be made 50% in cash and 50% in Company stock. The aggregate number of shares that may be issued under the plan must not exceed 50,000.

    F-42

     

    PART II

    INFORMATION NOT REQUIRED IN PROSPECTUS

    Item 24. Indemnification of Directors and Officers

            Under Section 145(a) of the General Corporation Law of Delaware, we may indemnify any of our officers or directors in any action other than actions by or in the right of our company, whether civil, criminal, administrative or investigative, if such director or officer acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of our company, and, with respect to any criminal action or proceedings if such director or officer has no reasonable cause to believe his conduct was unlawful. Under Section 145(b), we may indemnify any of our officers or directors in any action by or in the right of our company against expenses actually and reasonably incurred by him in the defense or settlement of such action if such officer or director acted in good faith and in a manner he reasonably believed to be in or not opposed to our best interest, except where such director or officer shall have been adjudged to be liable for negligence or misconduct in the performance of his duty to us, unless, on application, the Court of Chancery or the court in which such action or suit was brought shall determine that, despite the adjudication of liability, such person in view of all the circumstances is fairly and reasonably entitled to indemnity for such expenses as the court shall deem proper. Section 145(c) provides for mandatory indemnification of officers or directors who have been successful on the merits or otherwise in the defense of any action, suit or proceeding referred to in subsections (a) and (b). Section 145(d) authorizes indemnification under subsections (a) and (b) in specific cases if approved by our board of directors or stockholders upon a finding that the officer or director in question has met the requisite statutory standards of conduct. Section 145(g) empowers us to purchase insurance coverage for any director, officer, employee or agent against any liability incurred by him in his capacity as such, whether or not we would have the power to indemnify him under the provisions of the Delaware General Corporation Law. The foregoing is only a summary of the described sections of the Delaware General Corporation Law and is qualified in its entirety by reference to such sections.

            Our bylaws provide that we shall indemnify each of our officers and directors to the fullest extent permitted by applicable law. Our certificate of incorporation also provides that, to the fullest extent permitted by the Delaware General Corporation Law, our directors shall not be liable to us or our stockholders for monetary damages for breach of fiduciary duty as a director.

    Item 25. Other Expenses of Issuance and Distribution

            The following table sets forth the various expenses expected to be incurred in connection with the sale and distribution of the securities being registered, all of which will be borne the Registrant (not including any underwriting discounts and commissions and expenses incurred by the selling securityholders for brokerage, accounting, tax, or legal services or any other expenses incurred by the selling securityholders in disposing of the shares). All amounts shown are estimates except the Securities and Exchange Commission registration fee.

     

    Securities and Exchange registration fee

    $ 7,734

     

    Printing expenses

    $500

     

    Legal fees and expenses

    $35,000

    -1-

     

    Accounting fees and expenses

    $5,000

     

    Blue sky fees and expenses

    $3,000

     

    Transfer Agent and Registrar fees and expenses

    $1,000

     

    Miscellaneous

    $1,776

     

               Total

    $54,000

    Item 26. Recent Sales of Unregistered Securities

    Item 3.02 Unregistered Sales of Equity Securities

              Information concerning all securities that we sold without registering them under the Securities Act is incorporated by reference to information contained as indicated in the following reports filed with the SEC:

      (1) Form 10-QSB for the period ended 9/30/02, filed on 11/14/02 -- Part II, Item 2.
      (2) Form 10-QSB/A for the period ended 12/31/02, filed on 1/17/03 -- Part II, Item 2.
      (3) Form 10-KSB for the fiscal year ended 3/31/03, filed on 7/1/03 -- Part II, Item 5(d).
      (4) Form 10-QSB/A for the period ended 6/30/03, filed on 11/21/03 -- Part II, Item 2.
      (5) Form 10-QSB for the period ended 9/30/03, filed on 11/13/03 -- Part II, Item 2.
      (6) Form 10-QSB for the period ended 12/31/03, filed on 2/17/04 -- Part II, Item 2.
      (7) Form 10-KSB for the fiscal year ended 3/31/04, filed on 7/1/04 -- Part II, Item 5(d).
      (8) Form 10-QSB for the period ended 6/30/04, filed on 8/23/04 -- Part II, Item 2.
      (9) Form 10-QSB for the period ended 9/30/04, filed on 11/22/04 -- Part II, Item 2.
      (10) Form 8-K/A dated 12/16/05, filed on 3/2/05 -- Item 3.02.
      (11) Form 8-K dated 2/8/05, filed on 2/14/05 -- Item 3.20.
      (12) Form 8-K, dated 6/8/05, filed on 6/14/05 -- Item 3.02.
      (13) Form 8-K, dated 6/17/05, filed on 6/21/05 -- Item 3.02.

            For information concerning the purchasers in our unregistered offerings and regarding commissions and fees paid to underwriters, see the information presented under the heading "Certain Relationships and Related Party Transactions" in the prospectus contained in this registration statement, which is incorporated by reference.

            During the period from June 10, 2005 through July 1, 2005, we sold 11,260 shares of Series A convertible preferred stock and warrants to purchase 2,815,000 shares of common stock for an aggregate price of $11.26 million. Each share of Series A preferred stock is convertible into 500 shares of common stock, and the related warrants are exercisable for a period of three years at $3.85 per share of common stock. The sales were made to 19 persons and entities, with substantially all of the shares being purchased by institutional investors and their related parties. The sales of Series A convertible preferred stock and warrants were made pursuant to an exemption from registration under Section 4(2) of the Securities Act and Rule 506 of Regulation D under the Securities Act in an offering made exclusively to accredited investors, as that term is defined in Rule 501 of Regulation D. In connection with the sales, we paid placement agent fees and/ or finders aggregate cash fees of $1,101,000 and warrants exercisable for a period of 7 years to purchase 563,000 shares of common stock at $2.00 per share. The principal placement agents for the sales were KeyBanc Capital Markets and Chadbourn Securities, Inc.

    Item 27. Exhibits and Financial Statement Schedules

    -2-

            The following exhibits are filed as part of this registration statement:

      2.1 Agreement and Plan of Exchange, dated as of July 15, 2004, by and among Technology Acquisition Corporation, Minrad Inc., and Technology Acquisition Subsidiary, Inc. (incorporated by reference to Exhibit 2.1 to Form 8-K filed on July 15, 2004).
         
      2.2 Amendment to Agreement and Plan of Exchange, dated as of August 24, 2004, by and among Minrad Inc., and Technology Acquisition Subsidiary, Inc. (incorporated by reference to Exhibit 99.1 to Form 8-K on August 30, 2004).
         
      3.1* Articles of Incorporation of Registrant.
         
      3.2 Bylaws of Registrant (incorporated by reference to Appendix E to definitive Proxy Statement as filed under Schedule 14A on April 6, 2005).
         
      4.1 Form of Warrant Agreement, dated December 15, 2004, by and among Minrad International, Inc., Minrad Inc., Cagan McAfee Partners, LLC and Chadbourne Securities, Inc. (incorporated by reference to Exhibit 4.1 to Form 8-K filed on December 21, 2004).
         
      4.1 Form of Stock Option Agreement, dated December 15, 2004 by and among the Registrant, Minrad Inc., Cagan McAfee Capital Partners, LLC, Liviakis Financial Communications, Inc., Laird Q. Cagan, Eric McAfee and the Tobin Family Trust (incorporated by reference to Exhibit 4.2 to Form 8-K filed on December 21, 2004).
         
      4.3 Form of Registration Rights Agreement by and between Minrad Inc. and the Investors (incorporated by reference to Exhibit 4.4 to Form 8-K filed on December 21, 2004).
         
      4.4 Form of Registration Rights Agreement between Minrad and purchasers of $2.5 million of convertible promissory notes (incorporated by reference to Exhibit 99.5 to Form 8-K filed on February 14, 2005)
         
      4.5 Form of Warrant Agreement between Minrad and purchasers of $2.5 million of convertible promissory notes (incorporated by reference to Exhibit 99.4 to Form 8-K filed on February 14, 2005).
         
      4.6 Form of Warrant dated June 10, 2005 between Minrad and the purchasers of $7.035 million of Series A preferred stock and related warrants (incorporated by reference to Exhibit 99.3 to Form 8-K filed on June 14, 2005).
         
      4.7 Form of Warrant dated June 21, 2005 between Minrad and the purchasers of $3 million of Series A preferred stock and related warrants (incorporated by reference to Exhibit 99.3 to Form 8-K filed on June 21, 2005).
      4.8 Form of Warrant dated July 1, 2005 between Minrad and the purchasers of $1.225 million of Series A preferred stock and related warrants -- to be filed by amendment.

     

       

    -3-

     

      4.9 Form of Registration Rights Agreement dated June 8, 2005 between Minrad and the purchasers of $7.035 million of Series A preferred stock and related warrants (incorporated by reference to Exhibit 99.4 to Form 8-K filed on June 14, 2005).
         
      4.10 Form of Registration Rights Agreement dated June 17, 2005 between Minrad and the purchasers or $3 million of Series A preferred stock and related warrants (incorporated by reference to Exhibit 99.4 to Form 8-K filed on June 21, 2005).
         
      4.11 Form of Registration Rights Agreement dated June 28, 2005 between Minrad and the purchasers of $1.225 million of Series A preferred stock and related warrants -- to be filed by amendment.
         
      5.0 Opinion re legality of shares to be issued -- to be filed by amendment.
         
      10.0 Engagement Letter, dated December 1, 2003 by and between Minrad Inc. and Cagan McAfee Capital Partners, LLC. (incorporated by reference to Exhibit 8.0 to Form 8-K filed on December 21, 2004).
         
      10.1 Employment Agreement of William H. Burns, Jr., dated March 1, 2004 (incorporated by reference to Exhibit 10.1 to Form 8-K filed on December 21, 2004).
         
      10.2 Employment Agreement of John McNeirney, dated March 29, 2004 (incorporated by reference to Exhibit 10.2 to Form 8-K filed on December 21, 2004).
         
      10.3 Lease of 847 Main Street, Buffalo, New York (incorporated by reference to Exhibit 10.3 to Form 8-K filed on December 21, 2004).
         
      10.4 Contingent Appointment Letter for William Bednarski, dated January 25, 2005 (incorporated by reference to Exhibit 99.2 to Form 8-K filed on February 23, 2005).
         
      10.5 Supply Agreement, effective February 11, 2005, between Minrad EU and Merk Generiques (incorporated by reference to Exhibit 10.1 to Form 8-K filed on February 24, 2005).
         
      10.6 Minrad Inc. Patents and Inventions Policy (incorporated by reference to Exhibit 10.6 to Form 10-KSB filed on March 31, 2005).
         
      10.7 Minrad International, Inc. 2004 Stock Option Plan (incorporated by reference to Appendix C to Schedule 14C filed on September 16, 2004).
         
      10.8 Exclusive Manufacturing and Distribution Agreement, effective June 9, 2004, and Addendum to Distribution Agreement, made as of March 28, 2005 between Minrad Inc. and RX Elite Holdings Inc. (incorporated by reference to Exhibit 10.8 to Form 10-QSB filed on May 13, 2005).

     

       

    -4-

     

      10.8 Form of Convertible Promissory Note used in connection with $2.5 million aggregate amount of notes dated February 8 and February 15, 2005 (incorporated by reference to Exhibit 99.3 to Form 8-K filed on February 14, 2005).
         
      10.9 Amendments dated May 11, 2005 and May __ , 2005 to $2.5 million Convertible Promissory Notes dated February 8, 2005 and February 15, 2005.
         
      10.10 Form of Guaranty Agreement used in connection with $2.5 million Convertible Promissory Notes (incorporated by reference to Exhibit 99.6 to Form 8-K filed on February 14, 2005).
         
      10.11 Securities Purchase Agreement, dated May __ 2004, among Wilhelm Liesner, Markus Liesner, Kay Velmeden as sellers, and Laird Cagan, Eric McAfee, International Capital Advisory, Inc., John Liviakis, John Pimental, Thomas Caleel, Devin Bosch, Jon Roylance, and Robert Krueger as purchasers (incorporated by reference to Exhibit 99.1 to Form 8-K filed on May 27, 2004).
         
      10.12 Assignment and Assumption Agreement, dated May __, 2004, among Wilhelm Liesner as seller and Laird Cagan, Eric McAfee, and International Capital Advisory, Inc. as buyers (incorporated by reference to Exhibit 99.2 to Form 8-K filed on May 27, 2004).
         
      10.13 Advisory Agreement, dated May 21, 2004, among Cagan McAfee Capital Partners, LLC, Morrie Tobin, and Technology Acquisition Corporation (incorporated by reference to Exhibit 99.3 to Form 8-K filed on May 27, 2004).
         
      10.14 Consulting Agreement, dated May__, 2004, between Technology Acquisition Corporation and Liviakis Financial Communications, Inc. (incorporated by reference to Exhibit 99.4 to Form 8-K filed May 27, 2004).
         
      10.15 Note Subscription Agreement dated February 8, 2005 between Minrad and the Tobin Family Trust relating to the sale of $1.5 million of convertible promissory notes (incorporated by reference to Exhibit 99.1 to Form 8-K filed on February 14, 2005).
         
      10.16 Note Subscription Agreement dated February 8, 2005 between Minrad and Laird Cagan relating to the sale of $1 million of convertible promissory notes (incorporated by reference to Exhibit 99.2 to Form 8-K filed on February 14, 2005).
         
      10.17 Securities Purchase Agreement, dated June 8, 2005, between Minrad and investors in $7.035 million of Series A preferred stock and related warrants (incorporated by reference to Exhibit 99.1 to Form 8-K filed on June 14, 2005).
         
      10.18 Securities Purchase Agreement, dated June 17, 2005, between Minrad and investors in $3 million of Series A preferred stock and related warrants (incorporated by reference to Exhibit 99.1 to Form 8-K filed on June 21, 2005).
         
       

    -5-

     

      16.1 Letter from Clancy and Co., P.L.L.C. regarding a change in certifying accountants (incorporated by reference to Exhibit 16 to Form 8-K/A filed on January 19, 2005).
         
      21. Subsidiaries of the Registrant (incorporated by reference to Exhibit 21 to Form 10-KSB filed on March 31, 2005).
         
      23.1* Consent of Freed Maxick & Battaglia, CPA's, PC.
         
      23.2* Consent of Hodgson Russ LLP.

    ________________

    * Filed herewith

    Item 28. Undertakings

              (a) The undersigned registrant hereby undertakes:

                        (1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

                                  (i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

                                  (ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in the amount of volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement.

                                  (iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

                        (2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

                        (3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

              (b) Insofar as indemnification for liabilities arising under the Securities Act of 1933 (the "Act") may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is,

    -6-

    therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question of whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

    -7-

    SIGNATURES

              Pursuant to the requirements of the Securities Act, the registrant has duly caused this Amendment to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Buffalo, State of New York, on July 1, 2005.

    MINRAD INTERNATIONAL, INC.

    By: /s/ William H. Burns, Jr.                     
          William H. Burns, Jr.
          Chairman and Chief Executive Officer

              Pursuant to the requirements of the Securities Act of 1933, this Amendment to Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

     

    Signature

    Title

    Date

    /s/ William H. Burns, Jr.                  

    William H. Burns, Jr.

    Chairman, Chief Executive Officer, and Director
    (Principal Executive Officer)

     

    July 1, 2005

     

    /s/ Richard Tamulski                       

    Richard Tamulski

     

    Vice President Finance
    (Principal Financial Officer)

    June 30, 2005

     

     

    /s/ William Rolfe                             

    William Rolfe

     

    Comptroller

    (Principal Accounting Officer)

     

    June 30, 2005

     

                                                          

    David DiGiacinto

     

    Director

    June __, 2005

     

    /s/ David Donaldson                       

    David Donaldson

    Director

    June 30, 2005

     

                                                          

    Donald Farley

    Director

    June __, 2005

     

                                                          

    Duane Hopper

     

    Director

     

    June __, 2005

     

    /s/ Robert Lifeso                             

    Robert Lifeso

    Director

     

    June 30, 2005

     

     

    -8-

     
         

    /s/ John Rousseau                           

    John Rousseau

    Director

    June 30, 2005

    -9-