Exhibit 99.2
Page | |
F-2 - F-3 | |
F-4 | |
F-5 | |
F-6 | |
F-7 - F-15 |
June 30,
|
December 31,
|
|||||||
2023
|
2022
|
|||||||
Unaudited
|
||||||||
ASSETS
|
||||||||
CURRENT ASSETS:
|
||||||||
Cash and cash equivalents
|
$
|
|
$
|
|
||||
Restricted cash
|
|
|
||||||
Short-term bank deposits
|
|
|
||||||
Investment in marketable securities
|
|
|
||||||
Other accounts receivable and prepaid expenses
|
|
|
||||||
Total current assets
|
|
|
||||||
NON-CURRENT ASSETS:
|
||||||||
Long-term prepaid expenses
|
|
|
||||||
Severance pay fund
|
|
|
||||||
Operating lease right to use asset
|
|
|
||||||
Property and equipment, net
|
|
|
||||||
Total non-current assets
|
|
|
||||||
Total assets
|
$
|
|
$
|
|
June 30,
|
December 31,
|
|||||||
2023
|
2022
|
|||||||
Unaudited
|
||||||||
LIABILITIES AND SHAREHOLDERS' EQUITY
|
||||||||
CURRENT LIABILITIES:
|
||||||||
Trade payables
|
$
|
|
$
|
|
||||
Short-term deferred participation in R&D expenses
|
|
|
||||||
Current maturity of operating lease liability
|
|
|
||||||
Other accounts payable and accrued expenses
|
|
|
||||||
Total current liabilities
|
|
|
||||||
NON- CURRENT LIABILITIES:
|
||||||||
Long term operating lease liability
|
|
|
||||||
Accrued severance pay
|
|
|
||||||
Total non-current liabilities
|
|
|
||||||
COMMITMENTS AND CONTINGENT LIABILITIES (NOTE 5)
|
||||||||
SHAREHOLDERS' EQUITY:
|
||||||||
Share capital:
|
||||||||
Ordinary shares of NIS
|
|
|
||||||
Additional paid-in capital
|
|
|
||||||
Accumulated deficit
|
(
|
)
|
(
|
)
|
||||
Total shareholders' equity
|
|
|
||||||
Total liabilities and shareholders' equity
|
$
|
|
$
|
|
Six months ended
June 30,
|
||||||||
2023
|
2022
|
|||||||
Unaudited
|
||||||||
Operating expenses:
|
||||||||
Research and development expenses, net
|
$
|
|
$
|
|
||||
Marketing and business development expenses
|
|
|
||||||
General and administrative expenses
|
|
|
||||||
Total operating expenses
|
|
|
||||||
Financial and other income, net
|
|
|
||||||
Loss before taxes on income
|
|
|
||||||
Tax benefit
|
|
|
||||||
Net loss
|
$
|
|
$
|
|
||||
Other comprehensive loss: | ||||||||
Change in unrealized gains (losses) on marketable securities: | ||||||||
Unrealized gains (losses) arising during the period, net
|
$
|
|
$
|
|
||||
Total comprehensive loss
|
$
|
|
$
|
|
||||
Basic and diluted net loss per share
|
$
|
|
$
|
|
||||
Weighted average number of ordinary shares used in computing basic and diluted net loss per share
|
|
|
Ordinary shares
|
Additional paid-in
|
Accumulated
|
Total shareholders’
|
|||||||||||||||||
Number
|
Amount
|
capital
|
deficit
|
equity
|
||||||||||||||||
Balance as of January 1, 2022
|
|
$
|
|
$
|
|
$
|
(
|
)
|
$
|
|
||||||||||
Options exercised
|
|
|
|
|
|
|||||||||||||||
Issuance of ESPP shares
|
|
|
|
|
|
|||||||||||||||
Stock-based compensation issued to employees, directors and non-employees
|
-
|
|
|
|
|
|||||||||||||||
Net loss
|
-
|
|
|
(
|
)
|
(
|
)
|
|||||||||||||
Balance as of June 30, 2022 (unaudited)
|
|
$
|
|
$
|
|
$
|
(
|
)
|
$
|
|
||||||||||
Balance as of January 1, 2023
|
|
$
|
|
$
|
|
$
|
(
|
)
|
$
|
|
||||||||||
Issuance of shares, net
|
|
|
|
|
|
|||||||||||||||
Stock-based compensation issued to employees, directors and non-employees
|
-
|
|
|
|
|
|||||||||||||||
Other comprehensive income (loss) from marketable securities, net
|
|
|
||||||||||||||||||
Net loss
|
-
|
|
|
(
|
)
|
(
|
)
|
|||||||||||||
-
|
||||||||||||||||||||
Balance as of June 30, 2023 (unaudited)
|
|
$
|
|
$
|
|
$
|
(
|
)
|
$
|
|
Six months ended
June 30,
|
||||||||
2023
|
2022
|
|||||||
Unaudited
|
||||||||
Cash flows from operating activities:
|
||||||||
Net loss
|
$
|
(
|
)
|
$
|
(
|
)
|
||
Adjustments required to reconcile net loss to net cash used in operating activities:
|
||||||||
Stock-based compensation
|
|
|
||||||
Depreciation
|
|
|
||||||
Accretion of discount on marketable securities
|
(
|
)
|
|
|||||
Realized gain on sale of marketable securities, net
|
(
|
)
|
|
|||||
Increase (decrease) in severance pay, net
|
|
(
|
)
|
|||||
Decrease in operating lease right of use asset
|
|
|
||||||
Increase in interest receivables from short-term bank deposits
|
(
|
)
|
(
|
)
|
||||
Decrease (increase) in other accounts receivable and prepaid expenses
|
(
|
)
|
|
|||||
Decrease (increase) in long-term prepaid expenses
|
(
|
)
|
|
|||||
Decrease in trade payables
|
(
|
)
|
(
|
)
|
||||
Increase (decrease) in other accounts payable and accrued expenses
|
(
|
)
|
|
|||||
Decrease in operating lease liability
|
(
|
)
|
(
|
)
|
||||
Decrease in deferred participation in R&D expenses
|
(
|
)
|
(
|
)
|
||||
Net cash used in operating activities
|
(
|
)
|
(
|
)
|
||||
Cash flows from investing activities:
|
||||||||
Proceeds from maturity of short-term bank deposits
|
|
|
||||||
Investment in short-term bank deposits
|
(
|
)
|
(
|
)
|
||||
Proceeds from maturity of marketable securities
|
|
|
||||||
Investment in marketable securities
|
(
|
)
|
|
|||||
Purchase of property and equipment
|
(
|
)
|
(
|
)
|
||||
Net cash provided by investing activities
|
|
|
||||||
Cash flows from financing activities:
|
||||||||
Proceeds from issuance of ordinary shares, net
|
|
|
||||||
Proceeds from exercise of options
|
|
|
||||||
Net cash provided by financing activities
|
|
|
||||||
Increase (decrease) in cash, cash equivalents and restricted cash
|
|
(
|
)
|
|||||
Cash, cash equivalents and restricted cash at the beginning of the period
|
|
|
||||||
Cash, cash equivalents and restricted cash at the end of the period
|
$
|
|
$
|
|
||||
Supplemental disclosure of non-cash investing and financing activities:
|
||||||||
Purchase of property and equipment
|
$
|
(
|
)
|
$
|
(
|
)
|
||
Right-of-use asset obtained in exchange for operating lease liability
|
$
|
|
$
|
|
||||
Issuance expenses
|
$
|
|
$
|
|
NOTE 1:- | GENERAL |
a. |
Compugen Ltd. (the “Company”) is a clinical-stage therapeutic discovery and development company utilizing its broadly applicable predictive computational discovery capabilities to identify novel drug targets and new biological pathways to develop therapeutics in the field of cancer immunotherapy. Compugen’s innovative immuno-oncology pipeline consists of three clinical stage programs, targeting immune checkpoints Compugen discovered computationally by COM701, COM902 and rilvegostomig. The Company’s lead product candidates, COM701, a potential first-in-class anti-PVRIG antibody, and COM902, a potential best-in-class therapeutic anti-TIGIT antibody are in Phase 1 clinical trials in patients with MSS CRC and platinum resistant ovarian cancer. Rilvegostomig, a novel anti PD-1/TIGIT bispecific antibody with a TIGIT specific component that is derived from Compugen’s COM902 antibody, is being developed by AstraZeneca pursuant to an exclusive license agreement between Compugen and AstraZeneca and is in a Phase 2 clinical trial in patients with advanced or metastatic non-small cell lung and locally advanced or metastatic gastric cancer. In addition, the Company’s therapeutic pipeline of early-stage immuno-oncology programs consists of programs aiming to address various mechanisms of immune resistance. The most advanced preclinical program, COM503, is in IND enabling studies. COM503 is a potential first-in-class, high affinity antibody which blocks the interaction between IL-18 binding protein and IL-18, thereby freeing natural IL-18 to inhibit cancer growth in the tumor microenvironment.
|
b. |
The Company is headquartered in Holon, Israel. Its clinical development activities operate from its U.S. subsidiary in San Francisco, California.
|
c. |
The Company has incurred losses in the amount of $
|
d. |
On August 5, 2013, the Company entered into a Research and Development Collaboration and License Agreement (“Bayer Agreement”) with Bayer Pharma AG (“Bayer”) for the research, development, and commercialization of antibody-based therapeutics against two novel Compugen-discovered immune checkpoint regulators.
|
F - 7
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 1:- |
GENERAL (Cont.) |
e. |
Effective March 30, 2018, the Company entered into an exclusive license agreement with MedImmune Limited, the global biologics research and development arm of AstraZeneca (“AstraZeneca”) to enable the development of bi-specific and multi-specific immuno-oncology antibody products. Under the terms of the agreement, Compugen provided an exclusive license to AstraZeneca for the development of bi-specific and multi-specific antibody products derived from COM902. AstraZeneca has the right to create multiple products under this license and is solely responsible for all research, development and commercial activities under the agreement. Compugen received a $
|
f. |
On October 10, 2018, the Company entered into a Master Clinical Trial Collaboration Agreement (the “Master Clinical Agreement”) with Bristol Myers Squibb Company (“Bristol Myers Squibb”) to evaluate the safety and tolerability of Compugen’s COM701 in combination with Bristol Myers Squibb’s PD-1 immune checkpoint inhibitor Opdivo® (nivolumab), in patients with advanced solid tumors.
Pursuant to the Master Clinical Agreement, as amended from time to time, Compugen sponsored the trials, which included the evaluation of the combination of COM701 and Opdivo® ± Bristol Myers Squibb investigational anti-TIGIT, BMS-986207. Bristol Myers Squibb and Compugen each supplies its own compound(s) for the studies. In conjunction with the signing of the Master Clinical Agreement, Bristol Myers Squibb made a $ |
NOTE 2:- |
SIGNIFICANT ACCOUNTING POLICIES
|
F - 8
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 2:- |
SIGNIFICANT ACCOUNTING POLICIES (Cont.)
|
NOTE 3:- |
UNAUDITED INTERIM CONSOLIDATED FINANCIAL STATEMENTS
|
F - 9
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 4:- |
MARKETABLE SECURITIES
|
The following is a summary of available-for-sale marketable securities as of June 30, 2023:
|
Amortized |
Gross gains |
Gross losses |
Fair value |
||||||||||||
Available-for-sale – matures within one year: |
||||||||||||||||
Governmental bonds |
$ |
|
$ |
|
$ |
|
$ |
|
* Represents an amount lower than $1
The Company did not have investments in marketable securities as of June 30, 2022.
As of June 30, 2023, the Company did not record an allowance for credit losses for its available for sale marketable securities.
NOTE 5:-
|
COMMITMENTS AND CONTINGENCIES
|
a. |
The Company provided bank guarantees in the amount of $
|
b. |
The Company received in the past grants from the office of the Israel Innovation Authority of the Israeli Ministry of Industry, Trade and Labor, formerly known as the Office of the Chief Scientist (“IIA”). The Company is not obligated to repay any amounts received from the IIA if it does not generate any income from products which incorporate technologies which were funded by such research program(s).
|
c. |
On June 25, 2012, the Company entered into an Antibodies Discovery Collaboration Agreement (the “Antibodies Discovery Agreement”) with a U.S. antibody technology company (“mAb Technology Company”), providing an established source for fully human mAbs. Under the Antibodies Discovery Agreement, the mAb Technology Company is entitled to certain royalties that could be eliminated upon payment of certain one-time fees (all milestone and royalties payments referred together as “Contingent Fees”). For the six-month periods ended June 30, 2023 and 2022, the Company did not incur Contingent Fees.
|
F - 10
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 5:- |
COMMITMENTS AND CONTINGENCIES (Cont.)
|
d. |
On
|
The Bayer Agreement was terminated effective February 27, 2023 and no further payments to the Advisor are expected under the May 2012 Agreement.
e. |
Effective as of January 5, 2018, the Company entered into a Commercial License Agreement (“CLA”) with a European cell line development company. Under the agreement the Company is required to pay an annual maintenance fee, certain amounts upon the occurrence of specified milestones events, and
|
f. |
Effective as of October 28, 2020, the Company entered into a collaboration agreement with a U.S. antibody discovery and optimization company for generation and optimization of therapeutic antibodies for the Company. Under the agreement, the Company is required to pay service fees per services performed and certain amounts upon the occurrence of specified milestones events, and single-digit percent royalties on annual net sales with respect to each product sold that comprises or contains one or more antibodies so generated or optimized. The royalty rate is dependent upon the product type and any third-party contribution. For the six-month periods ended June 30, 2023 and 2022 the Company did not incur milestone payments.
|
NOTE 6:- |
SHAREHOLDERS' EQUITY
|
a. |
Issuance of Shares:
|
F - 11
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 6:- |
SHAREHOLDERS’ EQUITY (Cont.)
|
F - 12
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 6:- |
SHAREHOLDERS’ EQUITY (Cont.)
|
b. |
Share option plan:
|
Six months ended
June 30,
|
||||||||
2023
|
2022
|
|||||||
Unaudited
|
||||||||
Volatility
|
|
%
|
|
%
|
||||
Risk-free interest rate
|
|
%
|
|
%
|
||||
Dividend yield
|
|
%
|
|
%
|
||||
Expected life (years)
|
|
|
F - 13
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 6:- |
SHAREHOLDERS’ EQUITY (Cont.)
|
c. |
Employee Stock Purchase Plan:
|
Six months ended
June 30,
|
||||||||
2023
|
2022
|
|||||||
Unaudited
|
||||||||
Volatility
|
|
|
%
|
|||||
Risk-free interest rate
|
|
|
%
|
|||||
Dividend yield
|
|
|
%
|
|||||
Expected life (years)
|
|
|
NOTE 7:- |
FINANCIAL AND OTHER INCOME, NET |
Six months ended
June 30,
|
||||||||
2023
|
2022
|
|||||||
Unaudited
|
||||||||
Interest income
|
$
|
|
$
|
|
||||
Exchange rate differences and other
|
|
|
||||||
Financial and other income, net
|
$
|
|
$
|
|
F - 14
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 8:- |
RELATED PARTY BALANCES AND TRANSACTIONS |
June 30,
2023
|
December 31,
2022
|
|||||||
Unaudited
|
||||||||
Trade and other payables (a)
|
$
|
|
$
|
|
Six months ended
June 30,
|
||||||||
2023
|
2022
|
|||||||
Unaudited
|
||||||||
Amounts charged to:
|
||||||||
Research and development expenses (a)
|
$
|
|
$
|
|
(a) |
|
NOTE 9:- |
SUBSEQUENT EVENTS
|