The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M COMPANY COM 88579Y101 793 5,105 SH   SOLE   5,105 0 0
ABBVIE INC COM USD0.01 COM 00287Y109 2,635 38,632 SH   SOLE   38,632 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 18,528 444,425 SH   SOLE   444,425 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 3,856 223,200 SH   SOLE   223,200 0 0
ALIBABA GROUP HOLDING-SP SPON ADR 01609W102 6,931 84,460 SH   SOLE   84,460 0 0
AMAZON.COM INC COM 023135106 218 500 SH   SOLE   500 0 0
AMERICAN AIRLINES GROUP INC COM 02376R102 4,256 109,050 SH   SOLE   109,050 0 0
ANTERO RESOURCES CORPORATION U COM 03674X106 1,426 42,900 SH   SOLE   42,900 0 0
APPLE COMPUTER INC COM 037833100 22,432 177,419 SH   SOLE   177,419 0 0
ATT INC COM 00206R102 3,558 99,600 SH   SOLE   99,600 0 0
AURIS MEDICAL HOLDING AG CHF0. COM H03579101 116 20,900 SH   SOLE   20,900 0 0
BAIDU.COM SPON ADR REPA 056752108 985 5,000 SH   SOLE   5,000 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 776 5,650 SH   SOLE   5,650 0 0
BERKSHIRE HATHAWAY INC CL-A CLA 084670108 823 4 SH   SOLE   4 0 0
BIOGEN IDEC INC COM 09062X103 202 500 SH   SOLE   500 0 0
BLACKROCK MUN TARGET TERM TR C COM SHS BEN IN 09257P105 1,184 58,500 SH   SOLE   58,500 0 0
BLACKROCK MUNI INTER DURATION COM 09253X102 3,339 245,000 SH   SOLE   245,000 0 0
BOEING CO COM 097023105 2,992 21,345 SH   SOLE   21,345 0 0
BUNGE LIMITED COM STK USD0.01 COM G16962105 537 6,000 SH   SOLE   6,000 0 0
CARRIZO COM 144577103 319 7,000 SH   SOLE   7,000 0 0
CATERPILLAR INC COM 149123101 253 3,000 SH   SOLE   3,000 0 0
CBS CORP NEW CLASS B CL B 124857202 9,718 175,050 SH   SOLE   175,050 0 0
CELGENE CORP COM 151020104 16,392 137,150 SH   SOLE   137,150 0 0
CEMPRA INC COM 15130J109 7,294 218,450 SH   SOLE   218,450 0 0
CHARTER COMMUNICATIONS INC CL A NEW 16117M305 859 5,000 SH   SOLE   5,000 0 0
CHICAGO BRIDGE IRON COMPANY COM 167250109 4,138 82,951 SH   SOLE   82,951 0 0
CISCO SYSTEMS COM 17275R102 208 7,625 SH   SOLE   7,625 0 0
COLGATE PALMOLIVE CO COM 194162103 264 4,000 SH   SOLE   4,000 0 0
COMCAST CL A VTG CLA 20030N101 3,255 52,217 SH   SOLE   52,217 0 0
CONCHO RESOURCES COM 20605P101 2,017 17,950 SH   SOLE   17,950 0 0
CVS CAREMARK CORP COM 126650100 1,161 11,000 SH   SOLE   11,000 0 0
DEERE CO COM 244199105 511 5,307 SH   SOLE   5,307 0 0
DISCOVERY COMMUNICATIONS INC N COM SER A 25470F104 5,113 154,125 SH   SOLE   154,125 0 0
EMC CORPORATION COM 268648102 9,816 370,450 SH   SOLE   370,450 0 0
EOG RESOURCES INC COM 26875P101 2,041 23,830 SH   SOLE   23,830 0 0
EXPRESS SCRIPTS HLDG CO COM COM 30219G108 2,231 25,000 SH   SOLE   25,000 0 0
FEDEX CORP COM 31428X106 427 2,500 SH   SOLE   2,500 0 0
FIREEYE INC COM 31816Q101 12,090 250,900 SH   SOLE   250,900 0 0
GENERAL ELECTRIC CO COM 369604103 3,395 126,800 SH   SOLE   126,800 0 0
GILEAD SCIENCES COM 375558103 13,914 120,950 SH   SOLE   120,950 0 0
GOOGLE INC CLA 38259P508 3,059 5,590 SH   SOLE   5,590 0 0
GOOGLE INC CL C 38259P706 7,084 13,535 SH   SOLE   13,535 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1,209 54,750 SH   SOLE   54,750 0 0
HEXCEL COM 428291108 3,337 67,400 SH   SOLE   67,400 0 0
HONEYWELL INTL INC COM 438516106 512 5,000 SH   SOLE   5,000 0 0
INGERSOLL-RAND PLC SHS USD1 SHS G47791101 202 3,000 SH   SOLE   3,000 0 0
ISHARES SP 500 INDEX FUND CORE SP 500 E 464287200 312 1,500 SH   SOLE   1,500 0 0
ISHARES SP 500/BARRA GROWTH I SP 500 GRWT E 464287309 252 2,200 SH   SOLE   2,200 0 0
ISHARES TR IBOXX $ HIGH YIELD IBOXX HI YD ET 464288513 1,056 11,900 SH   SOLE   11,900 0 0
JOHNSON JOHNSON COM 478160104 511 5,200 SH   SOLE   5,200 0 0
JP MORGAN CHASE COM 46625H100 337 5,000 SH   SOLE   5,000 0 0
LAS VEGAS SANDS CORP COM 517834107 269 5,000 SH   SOLE   5,000 0 0
LOWES COMPANIES COM 548661107 680 10,200 SH   SOLE   10,200 0 0
MARINUS PHARMACEUTICALS INC CO COM 56854Q101 174 15,000 SH   SOLE   15,000 0 0
MASTERCARD INC CL A 57636Q104 593 6,300 SH   SOLE   6,300 0 0
MICROSOFT CORP COM 594918104 355 8,000 SH   SOLE   8,000 0 0
MOBILEYE NV EUR0.01 ORD SHS N51488117 327 6,000 SH   SOLE   6,000 0 0
MONSANTO CO NEW COM 61166W101 1,083 10,000 SH   SOLE   10,000 0 0
NATIONAL GRID NEW ADR EACH REP SPON ADR NEW 636274300 1,358 20,800 SH   SOLE   20,800 0 0
NEKTAR THERAPEUTICS COM 640268108 7,368 619,700 SH   SOLE   619,700 0 0
NEWFIELD EXPLORATION CO COM 651290108 1,823 52,050 SH   SOLE   52,050 0 0
NOVARTIS AG- SPON ADR 66987V109 2,659 26,650 SH   SOLE   26,650 0 0
NOVAVAX INC COM 670002104 6,658 611,950 SH   SOLE   611,950 0 0
ORACLE CORPORATION COM 68389X105 7,220 178,900 SH   SOLE   178,900 0 0
OTONOMY INC COM 68906L105 2,659 120,375 SH   SOLE   120,375 0 0
OUTFRONT MEDIA INC COM ISIN #U COM 69007J106 4,736 190,208 SH   SOLE   190,208 0 0
PFIZER INC COM 717081103 333 10,000 SH   SOLE   10,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 7,108 155,030 SH   SOLE   155,030 0 0
POTASH CORP SASK INC COM COM 73755L107 418 13,500 SH   SOLE   13,500 0 0
PRICELINE GROUP INC THE COM NEW 741503403 6,664 5,830 SH   SOLE   5,830 0 0
PROCTOR GAMBLE COM 742718109 247 3,100 SH   SOLE   3,100 0 0
PROOFPOINT INC COM 743424103 9,093 142,935 SH   SOLE   142,935 0 0
PRUDENTIAL FINANCIAL INC COM 744320102 4,072 46,187 SH   SOLE   46,187 0 0
QUALCOMM INC COM 747525103 3,951 62,620 SH   SOLE   62,620 0 0
RITE AID CORPORATION COM 767754104 922 110,000 SH   SOLE   110,000 0 0
SANCHEZ ENERGY CORP COM 79970Y105 881 95,800 SH   SOLE   95,800 0 0
SCHLUMBERGER LTD COM 806857108 336 4,000 SH   SOLE   4,000 0 0
SOCIEDAD QUIMICA MINERA DE CH SPON ADR SER B 833635105 451 28,000 SH   SOLE   28,000 0 0
TETRAPHASE PHARMACEUTICALS I COM 88165N105 14,061 293,675 SH   SOLE   293,675 0 0
THE WALT DISNEY CO COM DISNEY 254687106 2,370 20,620 SH   SOLE   20,620 0 0
TIME WARNER CABLE INC COM COM 88732J207 211 1,171 SH   SOLE   1,171 0 0
TIME WARNER INC NEW COM NEW 887317303 8,620 97,416 SH   SOLE   97,416 0 0
TWITTER INC COM USD0.000005 COM 90184L102 3,759 105,250 SH   SOLE   105,250 0 0
UNIQURE N.V. COM EUR0.05 SHS N90064101 1,152 43,465 SH   SOLE   43,465 0 0
UNITED PARCEL SERVICE INC CL B 911312106 340 3,500 SH   SOLE   3,500 0 0
UNITED TECHNOLOGIES CORP COM COM 913017109 262 2,400 SH   SOLE   2,400 0 0
VISA INC COM CL A 92826C839 484 7,100 SH   SOLE   7,100 0 0
WALGREENS BOOTS ALLIANCE INC C COM 931427108 858 10,000 SH   SOLE   10,000 0 0
YELP INC CL A 985817105 2,126 55,700 SH   SOLE   55,700 0 0