SCHEDULE 13G/A 0001104659-23-105374 0001346824 XXXXXXXX LIVE 2 Common Stock, par value $0.001 per share 03/31/2025 0001117480 CHIMERIX INC 16934W106 2505 MERIDIAN PARKWAY, SUITE 100 DURHAM NC 27713 Rule 13d-1(c) RA Capital Management, L.P. DE 0.00 0.00 0.00 0.00 0.00 0.0 IA PN Peter Kolchinsky X1 0.00 0.00 0.00 0.00 0.00 0.0 HC IN Rajeev Shah X1 0.00 0.00 0.00 0.00 0.00 0.0 HC IN RA Capital Healthcare Fund, L.P. DE 0.00 0.00 0.00 0.00 0.00 0.0 PN CHIMERIX INC 2505 MERIDIAN PARKWAY, SUITE 100, DURHAM, NC, 27713. The names of the persons filing this report (collectively, the "Reporting Persons") are: RA Capital Management, L.P. ("RA Capital") Peter Kolchinsky Rajeev Shah RA Capital Healthcare Fund, L.P. (the "Fund") The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13G. The address of the principal business office of each of the Reporting Persons is: c/o RA Capital Management, L.P., 200 Berkeley Street, 18th Floor, Boston MA 02116 RA Capital and the Fund are Delaware limited partnerships. Dr. Kolchinsky and Mr. Shah are United States citizens. Y Row 9 of each Reporting Person's cover page to this Schedule 13G sets forth the aggregate number of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference. Row 11 of each Reporting Person's cover page to this Schedule 13G sets forth the percentages of the securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference. Row 5 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference. Row 6 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference. Row 7 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference. Row 8 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference. N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement RA Capital Management, L.P. /s/ Peter Kolchinsky 05/15/2025 Peter Kolchinsky /s/ Peter Kolchinsky 05/15/2025 Rajeev Shah /s/ Rajeev Shah 05/15/2025 RA Capital Healthcare Fund, L.P. /s/ Peter Kolchinsky 05/15/2025