X0306 4 2018-05-08 0 0001117480 CHIMERIX INC CMRX 0001397329 Berrey M Michelle C/O CHIMERIX, INC. 2505 MERIDIAN PARKWAY, SUITE 100 DURHAM NC 27713 1 1 0 0 President and CEO Common Stock 2018-05-08 4 M 0 11250 4.26 A 325256 D Common Stock 89685 I By the M. Michelle Berrey Revocable Trust u/a 12/30/08 Stock Option (Right to Buy) 4.26 2018-05-08 4 M 0 11250 0.00 D 2022-11-17 Common Stock 11250 15161 D Includes 2,670 shares of Common Stock that were acquired by the Reporting Person on March 9, 2018 pursuant to the Issuer's Employee Stock Purchase Plan. Also, includes 25,000 shares of Common Stock issued pursuant to the vesting of restricted stock unit awards on May 9, 2018. Of the 325,256 shares noted above, 80,500 shares are time-based restricted stock unit awards that are unvested. In accordance with its terms, the shares underlying the option are subject to vesting as follows: 1/4th of the shares vest one year after November 12, 2012; the remainder of the shares vest in equal monthly installments thereafter over the next three years. /s/ Michael Alrutz, Attorney-in-Fact 2018-05-10