X0206 3 2018-03-28 0 0001117480 CHIMERIX INC CMRX 0001267959 MIDDLETON FRED A C/O CHIMERIX, INC. 2505 MERIDIAN PARKWAY, SUITE 100 DURHAM NC 27713 1 0 0 0 Common Stock 2776093 I See footnotes Common Stock 531861 I See footnotes Common Stock 3446 I See footnotes Common Stock 67523 D The securities are held as follows: 829,046 shares of common stock held by Sanderling Venture Partners V, L.P., 233,134 shares of common stock held by Sanderling V Biomedical, L.P., 155,143 shares of common stock held by Sanderling V Limited Partnership, 138,046 shares of common stock held by Sanderling V Beteiligungs GmbH & Co. KG, 199,853 shares of common stock held by Sanderling V Biomedical Co-Investment Fund, L.P., 329,682 shares of common stock held by Sanderling Venture Partners V Co-Investment Fund, L.P. and 891,189 shares of common stock held by Sanderling V Strategic Exit Fund, L.P. (collectively, the Sanderling V Shares). The Reporting Person, a director of Sanderling Ventures, may be deemed to beneficially own the Sanderling V Shares, the Sanderling VI Shares and the Middleton-McNeil Retirement Trust. The Reporting Person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein. The securities are held as follows: 498,046 shares of common stock held by Sanderling Venture Partners VI Co-Investment Fund, L.P., 15,431 shares of common stock held by Sanderling VI Beteiligungs GmbH & Co. KG and 18,384 shares of common stock held by Sanderling VI Limited Partnership (collectively, the Sanderling VI Shares). The securities are held as follows: 3,446 shares of common stock held by the Middleton-McNeil Retirement Trust. /s/ Michael Alrutz, Attorney-in-Fact 2018-04-06